RegulonDB RegulonDB

DnaA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
yjeV_mRNA RecF RpoA guaBA nrdAB-yfaE_mRNA lactaldehyde HolB stabilized RecA filament-DNA complex dnaAN-recF_mRNA RpoC dUDP rpoH_mRNA dADP single stranded DNA DnaE lactate polA_mRNA DnaX DnaX HolD aldA_mRNA dnaAN-recF adenylpyrophosphate double stranded DNA deoxynucleoside triphosphate RpoC dGDP L-glutamate DnaE HolC DnaN glycoaldehyde diphosphate xanthosine-5-P rpoH HolA NrdA RpoB GuaB RpoA HolD YfaE DnaA PolA HolE glycolate dCDP deoxynucleoside diphosphate RpoB mononucleotide adenylpyrophosphate RecF HolC guanylate GuaA nucleoside diphosphate HolA uridine-diphosphate DnaA guaBA_mRNA ammonium DnaQ thioredoxin disulfide nrdAB-yfaE RpoH polA YjeV guanosine-diphosphate DNA(N) DnaQ RecR reduced thioredoxin cytidine-diphosphate 5'-IMP AldA 5'-phosphomononucleotide HolB RecO glutamine yjeV DnaN unstable RecA filament-DNA complex NrdB HolE aldA RpoH NrdA NrdB RecO RecR glutamine L-glutamate guanylate ammonium xanthosine-5-P reduced thioredoxin dCDP thioredoxin disulfide reduced thioredoxin


Gensor Unit       
Name: DnaA
Classification:
Groups: Transcription
Energy production and conversion
Replication, recombination and repair
Nucleotide transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0071897 - DNA biosynthetic process
GO:0006310 - DNA recombination
GO:0006281 - DNA repair
GO:0006260 - DNA replication
GO:0006270 - DNA replication initiation
GO:0006271 - DNA strand elongation involved in DNA replication
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cellular_component GO:0009360 - DNA polymerase III complex
GO:0005737 - cytoplasm
GO:0009898 - cytoplasmic side of plasma membrane
GO:0005829 - cytosol
GO:0031421 - invertasome
GO:0005886 - plasma membrane
GO:0005971 - ribonucleoside-diphosphate reductase complex
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molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0008408 - 3'-5' exonuclease activity
GO:0008409 - 5'-3' exonuclease activity
GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0003688 - DNA replication origin binding
GO:0003700 - DNA-binding transcription factor activity
Read more >
Components:
  Function Name Type
  simple_molecule 5'-IMP simple_molecule
  simple_molecule 5'-phosphomononucleotide simple_molecule
  protein AldA protein
  simple_molecule DNA(N) simple_molecule
  protein DnaA protein
  complex DnaA-adenylpyrophosphate complex
  protein DnaE protein
  protein DnaN protein
  protein DnaQ protein
  protein DnaX protein
  protein GuaA protein
  protein GuaB protein
  protein HolA protein
  protein HolB protein
  protein HolC protein
  protein HolD protein
  protein HolE protein
  complex HolE-DnaQ-DnaE-HolA-HolB-DnaX-DnaN-HolD-HolC complex
  simple_molecule L-glutamate simple_molecule
  protein NrdA protein
  complex NrdA-NrdB complex
  protein NrdB protein
  protein PolA protein
  protein RecF protein
  complex RecF-RecR-RecO complex
  protein RecO protein
  protein RecR protein
  protein RpoA protein
  protein RpoB protein
  complex RpoB-RpoC-RpoA-RpoH complex
  protein RpoC protein
  protein RpoH protein
  protein YfaE protein
  protein YjeV protein
  simple_molecule adenylpyrophosphate simple_molecule
  gene aldA gene
  RNA aldA_mRNA RNA
  simple_molecule ammonium simple_molecule
  simple_molecule cytidine-diphosphate simple_molecule
  simple_molecule dADP simple_molecule
  simple_molecule dCDP simple_molecule
  simple_molecule dGDP simple_molecule
  simple_molecule dUDP simple_molecule
  simple_molecule deoxynucleoside diphosphate simple_molecule
  simple_molecule deoxynucleoside triphosphate simple_molecule
  simple_molecule diphosphate simple_molecule
  gene dnaAN-recF gene
  RNA dnaAN-recF_mRNA RNA
  simple_molecule double stranded DNA simple_molecule
  simple_molecule glutamine simple_molecule
  simple_molecule glycoaldehyde simple_molecule
  simple_molecule glycolate simple_molecule
  gene guaBA gene
  RNA guaBA_mRNA RNA
  simple_molecule guanosine-diphosphate simple_molecule
  simple_molecule guanylate simple_molecule
  simple_molecule lactaldehyde simple_molecule
  simple_molecule lactate simple_molecule
  simple_molecule mononucleotide simple_molecule
  gene nrdAB-yfaE gene
  RNA nrdAB-yfaE_mRNA RNA
  simple_molecule nucleoside diphosphate simple_molecule
  gene polA gene
  RNA polA_mRNA RNA
  simple_molecule reduced thioredoxin simple_molecule
  gene rpoH gene
  RNA rpoH_mRNA RNA
  simple_molecule single stranded DNA simple_molecule
  simple_molecule stabilized RecA filament-DNA complex simple_molecule
  simple_molecule thioredoxin disulfide simple_molecule
  simple_molecule unstable RecA filament-DNA complex simple_molecule
  simple_molecule uridine-diphosphate simple_molecule
  simple_molecule xanthosine-5-P simple_molecule
  gene yjeV gene
  RNA yjeV_mRNA RNA


Reactions       
Showing 40 reactions
adenylpyrophosphate + DnaA DnaA-adenylpyrophosphate
Name: adenylpyrophosphate + DnaA -> DnaA-adenylpyrophosphate
Description: Reaction transforming adenylpyrophosphate, DnaA into DnaA-adenylpyrophosphate
Type: state transition
Pathway Components: adenylpyrophosphate + DnaA -> DnaA-adenylpyrophosphate
Components:
Function Name Type
reactant DnaA protein
product DnaA-adenylpyrophosphate complex
reactant adenylpyrophosphate simple_molecule
DnaA-adenylpyrophosphate DnaA-adenylpyrophosphate nrdAB-yfaE nrdAB-yfaE_mRNA
Name: nrdAB-yfaE -> nrdAB-yfaE_mRNA
Description: Transcription of transcription unit nrdAB-yfaE. Reaction activation by DnaA-adenylpyrophosphate. Reaction inhibition by DnaA-adenylpyrophosphate.
Type: transcription
Pathway Components: nrdAB-yfaE - DnaA-adenylpyrophosphate - DnaA-adenylpyrophosphate -> nrdAB-yfaE_mRNA
Components:
Function Name Type
activator DnaA-adenylpyrophosphate complex
inhibitor DnaA-adenylpyrophosphate complex
reactant nrdAB-yfaE gene
product nrdAB-yfaE_mRNA RNA
DnaA-adenylpyrophosphate polA polA_mRNA
Name: polA -> polA_mRNA
Description: Transcription of transcription unit polA. Reaction activation by DnaA-adenylpyrophosphate.
Type: transcription
Pathway Components: polA - DnaA-adenylpyrophosphate -> polA_mRNA
Components:
Function Name Type
activator DnaA-adenylpyrophosphate complex
reactant polA gene
product polA_mRNA RNA
DnaA-adenylpyrophosphate DnaA-adenylpyrophosphate dnaAN-recF dnaAN-recF_mRNA
Name: dnaAN-recF -> dnaAN-recF_mRNA
Description: Transcription of transcription unit dnaAN-recF. Reaction activation by DnaA-adenylpyrophosphate. Reaction inhibition by DnaA-adenylpyrophosphate.
Type: transcription
Pathway Components: dnaAN-recF - DnaA-adenylpyrophosphate - DnaA-adenylpyrophosphate -> dnaAN-recF_mRNA
Components:
Function Name Type
activator DnaA-adenylpyrophosphate complex
inhibitor DnaA-adenylpyrophosphate complex
reactant dnaAN-recF gene
product dnaAN-recF_mRNA RNA
DnaA-adenylpyrophosphate aldA aldA_mRNA
Name: aldA -> aldA_mRNA
Description: Transcription of transcription unit aldA. Reaction inhibition by DnaA-adenylpyrophosphate.
Type: transcription
Pathway Components: aldA - DnaA-adenylpyrophosphate -> aldA_mRNA
Components:
Function Name Type
inhibitor DnaA-adenylpyrophosphate complex
reactant aldA gene
product aldA_mRNA RNA
DnaA-adenylpyrophosphate guaBA guaBA_mRNA
Name: guaBA -> guaBA_mRNA
Description: Transcription of transcription unit guaBA. Reaction inhibition by DnaA-adenylpyrophosphate.
Type: transcription
Pathway Components: guaBA - DnaA-adenylpyrophosphate -> guaBA_mRNA
Components:
Function Name Type
inhibitor DnaA-adenylpyrophosphate complex
reactant guaBA gene
product guaBA_mRNA RNA
DnaA-adenylpyrophosphate rpoH rpoH_mRNA
Name: rpoH -> rpoH_mRNA
Description: Transcription of transcription unit rpoH. Reaction inhibition by DnaA-adenylpyrophosphate.
Type: transcription
Pathway Components: rpoH - DnaA-adenylpyrophosphate -> rpoH_mRNA
Components:
Function Name Type
inhibitor DnaA-adenylpyrophosphate complex
reactant rpoH gene
product rpoH_mRNA RNA
DnaA-adenylpyrophosphate yjeV yjeV_mRNA
Name: yjeV -> yjeV_mRNA
Description: Transcription of transcription unit yjeV. Reaction inhibition by DnaA-adenylpyrophosphate.
Type: transcription
Pathway Components: yjeV - DnaA-adenylpyrophosphate -> yjeV_mRNA
Components:
Function Name Type
inhibitor DnaA-adenylpyrophosphate complex
reactant yjeV gene
product yjeV_mRNA RNA
dnaAN-recF_mRNA DnaA
Name: dnaAN-recF_mRNA -> DnaA
Description: Translation of DnaA
Type: translation
Pathway Components: dnaAN-recF_mRNA -> DnaA
Components:
Function Name Type
product DnaA protein
reactant dnaAN-recF_mRNA RNA
dnaAN-recF_mRNA DnaN
Name: dnaAN-recF_mRNA -> DnaN
Description: Translation of DnaN
Type: translation
Pathway Components: dnaAN-recF_mRNA -> DnaN
Components:
Function Name Type
product DnaN protein
reactant dnaAN-recF_mRNA RNA
Protein Monomers HolE-DnaQ-DnaE-HolA-HolB-DnaX-DnaN-HolD-HolC
Name: DnaE + HolC + DnaQ + HolA + DnaX + HolD + DnaN + HolE + HolB -> HolE-DnaQ-DnaE-HolA-HolB-DnaX-DnaN-HolD-HolC
Description: Reaction transforming DnaE, HolC, DnaQ, HolA, DnaX, HolD, DnaN, HolE, HolB into HolE-DnaQ-DnaE-HolA-HolB-DnaX-DnaN-HolD-HolC
Type: state transition
Pathway Components: DnaE + HolC + DnaQ + HolA + DnaX + HolD + DnaN + HolE + HolB -> HolE-DnaQ-DnaE-HolA-HolB-DnaX-DnaN-HolD-HolC
Components: Show/Hide Components Table
dnaAN-recF_mRNA RecF
Name: dnaAN-recF_mRNA -> RecF
Description: Translation of RecF
Type: translation
Pathway Components: dnaAN-recF_mRNA -> RecF
Components:
Function Name Type
product RecF protein
reactant dnaAN-recF_mRNA RNA
RecR + RecF + RecO RecF-RecR-RecO
Name: RecR + RecF + RecO -> RecF-RecR-RecO
Description: Reaction transforming RecR, RecF, RecO into RecF-RecR-RecO
Type: state transition
Pathway Components: RecR + RecF + RecO -> RecF-RecR-RecO
Components:
Function Name Type
reactant RecF protein
product RecF-RecR-RecO complex
reactant RecO protein
reactant RecR protein
RecF-RecR-RecO unstable RecA filament-DNA complex stabilized RecA filament-DNA complex
Name: unstable RecA filament-DNA complex -> stabilized RecA filament-DNA complex
Description: Reaction transforming unstable RecA filament-DNA complex into stabilized RecA filament-DNA complex
Type: state transition
Pathway Components: unstable RecA filament-DNA complex - RecF-RecR-RecO -> stabilized RecA filament-DNA complex
Components:
Function Name Type
catalyzer RecF-RecR-RecO complex
product stabilized RecA filament-DNA complex simple_molecule
reactant unstable RecA filament-DNA complex simple_molecule
nrdAB-yfaE_mRNA NrdA
Name: nrdAB-yfaE_mRNA -> NrdA
Description: Translation of NrdA
Type: translation
Pathway Components: nrdAB-yfaE_mRNA -> NrdA
Components:
Function Name Type
product NrdA protein
reactant nrdAB-yfaE_mRNA RNA
NrdB + NrdA NrdA-NrdB
Name: NrdB + NrdA -> NrdA-NrdB
Description: Reaction transforming NrdB, NrdA into NrdA-NrdB
Type: state transition
Pathway Components: NrdB + NrdA -> NrdA-NrdB
Components:
Function Name Type
reactant NrdA protein
product NrdA-NrdB complex
reactant NrdB protein
NrdA-NrdB dCDP nucleoside diphosphate + reduced thioredoxin Products
Name: nucleoside diphosphate + reduced thioredoxin -> deoxynucleoside diphosphate + thioredoxin disulfide
Description: Reaction transforming nucleoside diphosphate, reduced thioredoxin into deoxynucleoside diphosphate, thioredoxin disulfide
Type: state transition
Pathway Components: nucleoside diphosphate + reduced thioredoxin - NrdA-NrdB - dCDP -> deoxynucleoside diphosphate + thioredoxin disulfide
Components:
Function Name Type
catalyzer NrdA-NrdB complex
inhibitor dCDP simple_molecule
product deoxynucleoside diphosphate simple_molecule
reactant nucleoside diphosphate simple_molecule
reactant reduced thioredoxin simple_molecule
product thioredoxin disulfide simple_molecule
NrdA-NrdB cytidine-diphosphate + reduced thioredoxin thioredoxin disulfide + dCDP
Name: cytidine-diphosphate + reduced thioredoxin -> thioredoxin disulfide + dCDP
Description: Reaction transforming cytidine-diphosphate, reduced thioredoxin into thioredoxin disulfide, dCDP
Type: state transition
Pathway Components: cytidine-diphosphate + reduced thioredoxin - NrdA-NrdB -> thioredoxin disulfide + dCDP
Components:
Function Name Type
catalyzer NrdA-NrdB complex
reactant cytidine-diphosphate simple_molecule
product dCDP simple_molecule
reactant reduced thioredoxin simple_molecule
product thioredoxin disulfide simple_molecule
NrdA-NrdB uridine-diphosphate + reduced thioredoxin thioredoxin disulfide + dUDP
Name: uridine-diphosphate + reduced thioredoxin -> thioredoxin disulfide + dUDP
Description: Reaction transforming uridine-diphosphate, reduced thioredoxin into thioredoxin disulfide, dUDP
Type: state transition
Pathway Components: uridine-diphosphate + reduced thioredoxin - NrdA-NrdB -> thioredoxin disulfide + dUDP
Components:
Function Name Type
catalyzer NrdA-NrdB complex
product dUDP simple_molecule
reactant reduced thioredoxin simple_molecule
product thioredoxin disulfide simple_molecule
reactant uridine-diphosphate simple_molecule
NrdA-NrdB reduced thioredoxin thioredoxin disulfide + dADP
Name: reduced thioredoxin -> thioredoxin disulfide + dADP
Description: Reaction transforming reduced thioredoxin into thioredoxin disulfide, dADP
Type: state transition
Pathway Components: reduced thioredoxin - NrdA-NrdB -> thioredoxin disulfide + dADP
Components:
Function Name Type
catalyzer NrdA-NrdB complex
product dADP simple_molecule
reactant reduced thioredoxin simple_molecule
product thioredoxin disulfide simple_molecule
NrdA-NrdB guanosine-diphosphate + reduced thioredoxin thioredoxin disulfide + dGDP
Name: guanosine-diphosphate + reduced thioredoxin -> thioredoxin disulfide + dGDP
Description: Reaction transforming guanosine-diphosphate, reduced thioredoxin into thioredoxin disulfide, dGDP
Type: state transition
Pathway Components: guanosine-diphosphate + reduced thioredoxin - NrdA-NrdB -> thioredoxin disulfide + dGDP
Components:
Function Name Type
catalyzer NrdA-NrdB complex
product dGDP simple_molecule
reactant guanosine-diphosphate simple_molecule
reactant reduced thioredoxin simple_molecule
product thioredoxin disulfide simple_molecule
nrdAB-yfaE_mRNA NrdB
Name: nrdAB-yfaE_mRNA -> NrdB
Description: Translation of NrdB
Type: translation
Pathway Components: nrdAB-yfaE_mRNA -> NrdB
Components:
Function Name Type
product NrdB protein
reactant nrdAB-yfaE_mRNA RNA
nrdAB-yfaE_mRNA YfaE
Name: nrdAB-yfaE_mRNA -> YfaE
Description: Translation of YfaE
Type: translation
Pathway Components: nrdAB-yfaE_mRNA -> YfaE
Components:
Function Name Type
product YfaE protein
reactant nrdAB-yfaE_mRNA RNA
polA_mRNA PolA
Name: polA_mRNA -> PolA
Description: Translation of PolA
Type: translation
Pathway Components: polA_mRNA -> PolA
Components:
Function Name Type
product PolA protein
reactant polA_mRNA RNA
PolA double stranded DNA Products
Name: double stranded DNA -> 5'-phosphomononucleotide + single stranded DNA
Description: Reaction transforming double stranded DNA into 5'-phosphomononucleotide, single stranded DNA
Type: state transition
Pathway Components: double stranded DNA - PolA -> 5'-phosphomononucleotide + single stranded DNA
Components:
Function Name Type
product 5'-phosphomononucleotide simple_molecule
catalyzer PolA protein
reactant double stranded DNA simple_molecule
product single stranded DNA simple_molecule
PolA DNA(N) mononucleotide
Name: DNA(N) -> mononucleotide
Description: Reaction transforming DNA(N) into mononucleotide
Type: state transition
Pathway Components: DNA(N) - PolA -> mononucleotide
Components:
Function Name Type
reactant DNA(N) simple_molecule
catalyzer PolA protein
product mononucleotide simple_molecule
PolA deoxynucleoside triphosphate + DNA(N) diphosphate + DNA(N)
Name: deoxynucleoside triphosphate + DNA(N) -> diphosphate + DNA(N)
Description: Reaction transforming deoxynucleoside triphosphate, DNA(N) into diphosphate, DNA(N)
Type: state transition
Pathway Components: deoxynucleoside triphosphate + DNA(N) - PolA -> diphosphate + DNA(N)
Components:
Function Name Type
product DNA(N) simple_molecule
reactant DNA(N) simple_molecule
catalyzer PolA protein
reactant deoxynucleoside triphosphate simple_molecule
product diphosphate simple_molecule
yjeV_mRNA YjeV
Name: yjeV_mRNA -> YjeV
Description: Translation of YjeV
Type: translation
Pathway Components: yjeV_mRNA -> YjeV
Components:
Function Name Type
product YjeV protein
reactant yjeV_mRNA RNA
guaBA_mRNA GuaB
Name: guaBA_mRNA -> GuaB
Description: Translation of GuaB
Type: translation
Pathway Components: guaBA_mRNA -> GuaB
Components:
Function Name Type
product GuaB protein
reactant guaBA_mRNA RNA
GuaB ammonium guanylate 5'-IMP xanthosine-5-P
Name: 5'-IMP -> xanthosine-5-P
Description: Reaction transforming 5'-IMP into xanthosine-5-P
Type: state transition
Pathway Components: 5'-IMP - GuaB - ammonium - guanylate -> xanthosine-5-P
Components:
Function Name Type
reactant 5'-IMP simple_molecule
catalyzer GuaB protein
inhibitor ammonium simple_molecule
inhibitor guanylate simple_molecule
product xanthosine-5-P simple_molecule
guaBA_mRNA GuaA
Name: guaBA_mRNA -> GuaA
Description: Translation of GuaA
Type: translation
Pathway Components: guaBA_mRNA -> GuaA
Components:
Function Name Type
product GuaA protein
reactant guaBA_mRNA RNA
GuaA xanthosine-5-P + glutamine diphosphate + L-glutamate + guanylate
Name: xanthosine-5-P + glutamine -> diphosphate + L-glutamate + guanylate
Description: Reaction transforming xanthosine-5-P, glutamine into diphosphate, L-glutamate , guanylate
Type: state transition
Pathway Components: xanthosine-5-P + glutamine - GuaA -> diphosphate + L-glutamate + guanylate
Components:
Function Name Type
catalyzer GuaA protein
product L-glutamate simple_molecule
product diphosphate simple_molecule
reactant glutamine simple_molecule
product guanylate simple_molecule
reactant xanthosine-5-P simple_molecule
GuaA glutamine L-glutamate + ammonium
Name: glutamine -> L-glutamate + ammonium
Description: Reaction transforming glutamine into L-glutamate, ammonium
Type: state transition
Pathway Components: glutamine - GuaA -> L-glutamate + ammonium
Components:
Function Name Type
catalyzer GuaA protein
product L-glutamate simple_molecule
product ammonium simple_molecule
reactant glutamine simple_molecule
GuaA xanthosine-5-P + ammonium diphosphate + guanylate
Name: xanthosine-5-P + ammonium -> diphosphate + guanylate
Description: Reaction transforming xanthosine-5-P, ammonium into diphosphate, guanylate
Type: state transition
Pathway Components: xanthosine-5-P + ammonium - GuaA -> diphosphate + guanylate
Components:
Function Name Type
catalyzer GuaA protein
reactant ammonium simple_molecule
product diphosphate simple_molecule
product guanylate simple_molecule
reactant xanthosine-5-P simple_molecule
aldA_mRNA AldA
Name: aldA_mRNA -> AldA
Description: Translation of AldA
Type: translation
Pathway Components: aldA_mRNA -> AldA
Components:
Function Name Type
product AldA protein
reactant aldA_mRNA RNA
AldA lactaldehyde lactaldehyde lactate
Name: lactaldehyde -> lactate
Description: Reaction transforming lactaldehyde into lactate
Type: state transition
Pathway Components: lactaldehyde - AldA - lactaldehyde -> lactate
Components:
Function Name Type
catalyzer AldA protein
inhibitor lactaldehyde simple_molecule
reactant lactaldehyde simple_molecule
product lactate simple_molecule
AldA glycoaldehyde glycoaldehyde glycolate
Name: glycoaldehyde -> glycolate
Description: Reaction transforming glycoaldehyde into glycolate
Type: state transition
Pathway Components: glycoaldehyde - AldA - glycoaldehyde -> glycolate
Components:
Function Name Type
catalyzer AldA protein
inhibitor glycoaldehyde simple_molecule
reactant glycoaldehyde simple_molecule
product glycolate simple_molecule
rpoH_mRNA RpoH
Name: rpoH_mRNA -> RpoH
Description: Translation of RpoH
Type: translation
Pathway Components: rpoH_mRNA -> RpoH
Components:
Function Name Type
product RpoH protein
reactant rpoH_mRNA RNA
RpoB + RpoA + RpoC + RpoH RpoB-RpoC-RpoA-RpoH
Name: RpoB + RpoA + RpoC + RpoH -> RpoB-RpoC-RpoA-RpoH
Description: Reaction transforming RpoB, RpoA, RpoC, RpoH into RpoB-RpoC-RpoA-RpoH
Type: state transition
Pathway Components: RpoB + RpoA + RpoC + RpoH -> RpoB-RpoC-RpoA-RpoH
Components:
Function Name Type
reactant RpoA protein
reactant RpoB protein
product RpoB-RpoC-RpoA-RpoH complex
reactant RpoC protein
reactant RpoH protein
guanylate guanosine-diphosphate
Name: guanylate -> guanosine-diphosphate
Description: Transformation of guanylate into guanosine-diphosphate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: guanylate / GUANYL-KIN-RXN / guanosine-diphosphate
Components:
Function Name Type
product guanosine-diphosphate simple_molecule
reactant guanylate simple_molecule



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