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CueR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
CueR MoaC MoaD oxygen Cu(I)_Ext H2Dtpp-mP gold 5'-deoxyadenosine CueR SAM guanosine-triphosphate moaABCDE silver cueO_mRNA Fe+2 A(H2) silver CueR acceptors CopA copA gold cueO methionine 2-carboxymuconate MPT-Synthase-small-subunits diphosphate thiocarboxylated small subunit of molybdopterin synthase TMPQ MoaB Cu(II) Cu(I) MoaE moaABCDE_mRNA CueO MoaD MoaE copA_mRNA DMP 3',8-cH2GTP cPMP Cu(I) MoaA fe(iii) 2-pyrocatechuate CueR


Gensor Unit       
Name: CueR
Description: Molecular biology level
Detailed: In the presence of Cu(I), CueR positively regulates the expression of genes required for phenol oxidation of iron siderophores, ferroxidation, and efflux of monovalent copper and negatively regulates the expression of genes involved in conversion from guanosine-triphosphate to molybdopterin. Under this condition, CueR is modified to CueR-Cu(I), binds its target sites and enables the expression of some of its regulated genes and prevents the expression of other of its regulated genes.
Less detailed: In the presence of Cu(I).CueR positively regulates the expression of genes needed for cellular response to copper ion and negatively regulates the expression of genes involved in synthesis of molybdopterin guanine dinucleotide, a cofactor for many enzymes.

Physiology level
Detailed: The presence of Cu(I) induces genes necessary for cellular response to copper and repress the expression of genes involved with synthesis of molybdopterin. Under these conditions, the genes necessary for copper detoxification and iron homeostasis are expressed whereas that the genes necessary for synthesis of molybdopterin guanine dinucleotide, a cofactor for many enzymes, are not expressed.
Less detailed: The presence of Cu(I) induces genes needful for copper detoxification and iron homeostasis and repress the expression of genes necessary for synthesis of molybdopterin.
Classification:
Groups: Inorganic ion transport and metabolism
Coenzyme transport and metabolism
Cell cycle control, cell division, chromosome partitioning
Gene Ontology Terms (GO): biological_process GO:0006777 - Mo-molybdopterin cofactor biosynthetic process
GO:0006812 - cation transport
GO:0071280 - cellular response to copper ion
GO:0071292 - cellular response to silver ion
GO:0060003 - copper ion export
GO:0006825 - copper ion transport
Read more >
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0031224 - intrinsic component of membrane
GO:0016020 - membrane
GO:0019008 - molybdopterin synthase complex
Read more >
molecular_function GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0005524 - ATP binding
GO:0016887 - ATP hydrolysis activity
GO:0019829 - ATPase-coupled cation transmembrane transporter activity
GO:0061798 - GTP 3',8'-cyclase activity
GO:0005525 - GTP binding
GO:0015662 - P-type ion transporter activity
Read more >
Components:
  Function Name Type
  simple_molecule 2-carboxymuconate simple_molecule
  simple_molecule 2-pyrocatechuate simple_molecule
  simple_molecule 3',8-cH2GTP simple_molecule
  simple_molecule 5'-deoxyadenosine simple_molecule
  simple_molecule A(H2) simple_molecule
  protein CopA protein
  simple_molecule Cu(I) simple_molecule
  simple_molecule Cu(I)_Ext simple_molecule
  simple_molecule Cu(II) simple_molecule
  protein CueO protein
  protein CueR protein
  complex CueR-Cu(I) complex
  complex CueR-gold complex
  complex CueR-silver complex
  simple_molecule DMP simple_molecule
  simple_molecule Fe+2 simple_molecule
  simple_molecule H2Dtpp-mP simple_molecule
  simple_molecule MPT-Synthase-small-subunits simple_molecule
  protein MoaA protein
  protein MoaB protein
  protein MoaC protein
  protein MoaD protein
  complex MoaD-MoaE complex
  protein MoaE protein
  simple_molecule SAM simple_molecule
  simple_molecule TMPQ simple_molecule
  simple_molecule acceptors simple_molecule
  simple_molecule cPMP simple_molecule
  gene copA gene
  RNA copA_mRNA RNA
  gene cueO gene
  RNA cueO_mRNA RNA
  simple_molecule diphosphate simple_molecule
  simple_molecule fe(iii) simple_molecule
  simple_molecule gold simple_molecule
  simple_molecule guanosine-triphosphate simple_molecule
  simple_molecule methionine simple_molecule
  gene moaABCDE gene
  RNA moaABCDE_mRNA RNA
  simple_molecule oxygen simple_molecule
  simple_molecule silver simple_molecule
  simple_molecule thiocarboxylated small subunit of molybdopterin synthase simple_molecule


Reactions       
Showing 22 reactions
Cu(I) + CueR CueR-Cu(I)
Name: Cu(I) + CueR -> CueR-Cu(I)
Description: Reaction transforming Cu(I), CueR into CueR-Cu(I)
Type: state transition
Pathway Components: Cu(I) + CueR -> CueR-Cu(I)
Components:
Function Name Type
reactant Cu(I) simple_molecule
reactant CueR protein
product CueR-Cu(I) complex
CueR-Cu(I) copA copA_mRNA
Name: copA -> copA_mRNA
Description: Transcription of transcription unit copA. Reaction activation by CueR-Cu(I).
Type: transcription
Pathway Components: copA - CueR-Cu(I) -> copA_mRNA
Components:
Function Name Type
activator CueR-Cu(I) complex
reactant copA gene
product copA_mRNA RNA
CueR-Cu(I) cueO cueO_mRNA
Name: cueO -> cueO_mRNA
Description: Transcription of transcription unit cueO. Reaction activation by CueR-Cu(I).
Type: transcription
Pathway Components: cueO - CueR-Cu(I) -> cueO_mRNA
Components:
Function Name Type
activator CueR-Cu(I) complex
reactant cueO gene
product cueO_mRNA RNA
CueR-Cu(I) moaABCDE moaABCDE_mRNA
Name: moaABCDE -> moaABCDE_mRNA
Description: Transcription of transcription unit moaABCDE. Reaction inhibition by CueR-Cu(I).
Type: transcription
Pathway Components: moaABCDE - CueR-Cu(I) -> moaABCDE_mRNA
Components:
Function Name Type
inhibitor CueR-Cu(I) complex
reactant moaABCDE gene
product moaABCDE_mRNA RNA
silver + CueR CueR-silver
Name: silver + CueR -> CueR-silver
Description: Reaction transforming silver, CueR into CueR-silver
Type: state transition
Pathway Components: silver + CueR -> CueR-silver
Components:
Function Name Type
reactant CueR protein
product CueR-silver complex
reactant silver simple_molecule
gold + CueR CueR-gold
Name: gold + CueR -> CueR-gold
Description: Reaction transforming gold, CueR into CueR-gold
Type: state transition
Pathway Components: gold + CueR -> CueR-gold
Components:
Function Name Type
reactant CueR protein
product CueR-gold complex
reactant gold simple_molecule
cueO_mRNA CueO
Name: cueO_mRNA -> CueO
Description: Translation of CueO
Type: translation
Pathway Components: cueO_mRNA -> CueO
Components:
Function Name Type
product CueO protein
reactant cueO_mRNA RNA
CueO oxygen + Cu(I) Cu(II)
Name: oxygen + Cu(I) -> Cu(II)
Description: Reaction transforming oxygen, Cu(I) into Cu(II)
Type: state transition
Pathway Components: oxygen + Cu(I) - CueO -> Cu(II)
Components:
Function Name Type
reactant Cu(I) simple_molecule
product Cu(II) simple_molecule
catalyzer CueO protein
reactant oxygen simple_molecule
CueO 2-pyrocatechuate + oxygen 2-carboxymuconate
Name: 2-pyrocatechuate + oxygen -> 2-carboxymuconate
Description: Reaction transforming 2-pyrocatechuate, oxygen into 2-carboxymuconate
Type: state transition
Pathway Components: 2-pyrocatechuate + oxygen - CueO -> 2-carboxymuconate
Components:
Function Name Type
product 2-carboxymuconate simple_molecule
reactant 2-pyrocatechuate simple_molecule
catalyzer CueO protein
reactant oxygen simple_molecule
Cu(II) CueO oxygen + Fe+2 fe(iii)
Name: oxygen + Fe+2 -> fe(iii)
Description: Reaction transforming oxygen, Fe+2 into fe(iii)
Type: state transition
Pathway Components: oxygen + Fe+2 - CueO - Cu(II) -> fe(iii)
Components:
Function Name Type
inhibitor Cu(II) simple_molecule
catalyzer CueO protein
reactant Fe+2 simple_molecule
product fe(iii) simple_molecule
reactant oxygen simple_molecule
CueO oxygen + DMP TMPQ
Name: oxygen + DMP -> TMPQ
Description: Reaction transforming oxygen, DMP into TMPQ
Type: state transition
Pathway Components: oxygen + DMP - CueO -> TMPQ
Components:
Function Name Type
catalyzer CueO protein
reactant DMP simple_molecule
product TMPQ simple_molecule
reactant oxygen simple_molecule
moaABCDE_mRNA MoaA
Name: moaABCDE_mRNA -> MoaA
Description: Translation of MoaA
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaA
Components:
Function Name Type
product MoaA protein
reactant moaABCDE_mRNA RNA
MoaA guanosine-triphosphate + A(H2) + SAM Products
Name: guanosine-triphosphate + A(H2) + SAM -> 5'-deoxyadenosine + 3',8-cH2GTP + methionine + acceptors
Description: Reaction transforming guanosine-triphosphate, A(H2), SAM into 5'-deoxyadenosine, 3',8-cH2GTP , methionine , acceptors
Type: state transition
Pathway Components: guanosine-triphosphate + A(H2) + SAM - MoaA -> 5'-deoxyadenosine + 3',8-cH2GTP + methionine + acceptors
Components:
Function Name Type
product 3',8-cH2GTP simple_molecule
product 5'-deoxyadenosine simple_molecule
reactant A(H2) simple_molecule
catalyzer MoaA protein
reactant SAM simple_molecule
product acceptors simple_molecule
reactant guanosine-triphosphate simple_molecule
product methionine simple_molecule
moaABCDE_mRNA MoaB
Name: moaABCDE_mRNA -> MoaB
Description: Translation of MoaB
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaB
Components:
Function Name Type
product MoaB protein
reactant moaABCDE_mRNA RNA
moaABCDE_mRNA MoaC
Name: moaABCDE_mRNA -> MoaC
Description: Translation of MoaC
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaC
Components:
Function Name Type
product MoaC protein
reactant moaABCDE_mRNA RNA
MoaC 3',8-cH2GTP diphosphate + cPMP
Name: 3',8-cH2GTP -> diphosphate + cPMP
Description: Reaction transforming 3',8-cH2GTP into diphosphate, cPMP
Type: state transition
Pathway Components: 3',8-cH2GTP - MoaC -> diphosphate + cPMP
Components:
Function Name Type
reactant 3',8-cH2GTP simple_molecule
catalyzer MoaC protein
product cPMP simple_molecule
product diphosphate simple_molecule
moaABCDE_mRNA MoaD
Name: moaABCDE_mRNA -> MoaD
Description: Translation of MoaD
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaD
Components:
Function Name Type
product MoaD protein
reactant moaABCDE_mRNA RNA
MoaD + MoaE MoaD-MoaE
Name: MoaD + MoaE -> MoaD-MoaE
Description: Reaction transforming MoaD, MoaE into MoaD-MoaE
Type: state transition
Pathway Components: MoaD + MoaE -> MoaD-MoaE
Components:
Function Name Type
reactant MoaD protein
product MoaD-MoaE complex
reactant MoaE protein
MoaD-MoaE Reactants MPT-Synthase-small-subunits + H2Dtpp-mP
Name: thiocarboxylated small subunit of molybdopterin synthase + cPMP -> MPT-Synthase-small-subunits + H2Dtpp-mP
Description: Reaction transforming thiocarboxylated small subunit of molybdopterin synthase, cPMP into MPT-Synthase-small-subunits, H2Dtpp-mP
Type: state transition
Pathway Components: thiocarboxylated small subunit of molybdopterin synthase + cPMP - MoaD-MoaE -> MPT-Synthase-small-subunits + H2Dtpp-mP
Components:
Function Name Type
product H2Dtpp-mP simple_molecule
product MPT-Synthase-small-subunits simple_molecule
catalyzer MoaD-MoaE complex
reactant cPMP simple_molecule
reactant thiocarboxylated small subunit of molybdopterin synthase simple_molecule
moaABCDE_mRNA MoaE
Name: moaABCDE_mRNA -> MoaE
Description: Translation of MoaE
Type: translation
Pathway Components: moaABCDE_mRNA -> MoaE
Components:
Function Name Type
product MoaE protein
reactant moaABCDE_mRNA RNA
copA_mRNA CopA
Name: copA_mRNA -> CopA
Description: Translation of CopA
Type: translation
Pathway Components: copA_mRNA -> CopA
Components:
Function Name Type
product CopA protein
reactant copA_mRNA RNA
CopA Cu(I)_Ext Cu(I)
Name: Cu(I)_Ext -> Cu(I)
Description: Transport of Cu(I)_Ext through a bacterial membrane, leading to the presence of Cu(I) inside the cell.
Type: transport
Pathway Components: Cu(I)_Ext - CopA -> Cu(I)
Components:
Function Name Type
catalyzer CopA protein
product Cu(I) simple_molecule
reactant Cu(I)_Ext simple_molecule



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