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BolA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
dacC NAM-tetrapeptide NAM-pentapeptide ala diacetyl-L-lys-D-ala-D-ala AmpC ampC_mRNA nascent peptidoglycan with (L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide BolA diacetyl-lys-D-ala ampC beta-lactam DacC substituted beta-amino acid dacC_mRNA UDP-MurNAc-tetrapeptide UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine nascent peptidoglycan with (L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide


Gensor Unit       
Name: BolA
Classification:
Groups: Defense mechanisms
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:0017001 - antibiotic catabolic process
GO:0071555 - cell wall organization
GO:0009252 - peptidoglycan biosynthetic process
GO:0006508 - proteolysis
GO:0008360 - regulation of cell shape
GO:0046677 - response to antibiotic
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cellular_component GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
GO:0005886 - plasma membrane
molecular_function GO:0008800 - beta-lactamase activity
GO:0004180 - carboxypeptidase activity
GO:0004175 - endopeptidase activity
GO:0016787 - hydrolase activity
GO:0008658 - penicillin binding
GO:0008233 - peptidase activity
GO:0042803 - protein homodimerization activity
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Components:
  Function Name Type
  protein AmpC protein
  protein BolA protein
  protein DacC protein
  simple_molecule NAM-pentapeptide simple_molecule
  simple_molecule NAM-tetrapeptide simple_molecule
  simple_molecule UDP-MurNAc-tetrapeptide simple_molecule
  simple_molecule UDP-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine simple_molecule
  simple_molecule ala simple_molecule
  gene ampC gene
  RNA ampC_mRNA RNA
  simple_molecule beta-lactam simple_molecule
  gene dacC gene
  RNA dacC_mRNA RNA
  simple_molecule diacetyl-L-lys-D-ala-D-ala simple_molecule
  simple_molecule diacetyl-lys-D-ala simple_molecule
  simple_molecule nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide simple_molecule
  simple_molecule nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide simple_molecule
  simple_molecule substituted beta-amino acid simple_molecule


Reactions       
Showing 9 reactions
BolA BolA ampC ampC_mRNA
Name: ampC -> ampC_mRNA
Description: Transcription of transcription unit ampC. Reaction activation by BolA. Reaction inhibition by BolA.
Type: transcription
Pathway Components: ampC - BolA - BolA -> ampC_mRNA
Components:
Function Name Type
activator BolA protein
inhibitor BolA protein
reactant ampC gene
product ampC_mRNA RNA
BolA BolA dacC dacC_mRNA
Name: dacC -> dacC_mRNA
Description: Transcription of transcription unit dacC. Reaction activation by BolA. Reaction inhibition by BolA.
Type: transcription
Pathway Components: dacC - BolA - BolA -> dacC_mRNA
Components:
Function Name Type
activator BolA protein
inhibitor BolA protein
reactant dacC gene
product dacC_mRNA RNA
dacC_mRNA DacC
Name: dacC_mRNA -> DacC
Description: Translation of DacC
Type: translation
Pathway Components: dacC_mRNA -> DacC
Components:
Function Name Type
product DacC protein
reactant dacC_mRNA RNA
DacC Reactants Products
Name: nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide -> nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide + ala
Description: Reaction transforming nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide into nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide, ala
Type: state transition
Pathway Components: nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide - DacC -> nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide + ala
Components:
Function Name Type
catalyzer DacC protein
product ala simple_molecule
product nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine) tetrapeptide simple_molecule
reactant nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide simple_molecule
DacC diacetyl-L-lys-D-ala-D-ala diacetyl-lys-D-ala + ala
Name: diacetyl-L-lys-D-ala-D-ala -> diacetyl-lys-D-ala + ala
Description: Reaction transforming diacetyl-L-lys-D-ala-D-ala into diacetyl-lys-D-ala, ala
Type: state transition
Pathway Components: diacetyl-L-lys-D-ala-D-ala - DacC -> diacetyl-lys-D-ala + ala
Components:
Function Name Type
catalyzer DacC protein
product ala simple_molecule
reactant diacetyl-L-lys-D-ala-D-ala simple_molecule
product diacetyl-lys-D-ala simple_molecule
DacC Reactants UDP-MurNAc-tetrapeptide + ala
Name: UDP-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine -> UDP-MurNAc-tetrapeptide + ala
Description: Reaction transforming UDP-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine into UDP-MurNAc-tetrapeptide, ala
Type: state transition
Pathway Components: UDP-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine - DacC -> UDP-MurNAc-tetrapeptide + ala
Components:
Function Name Type
catalyzer DacC protein
product UDP-MurNAc-tetrapeptide simple_molecule
reactant UDP-N-acetylmuramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine simple_molecule
product ala simple_molecule
DacC NAM-pentapeptide NAM-tetrapeptide + ala
Name: NAM-pentapeptide -> NAM-tetrapeptide + ala
Description: Reaction transforming NAM-pentapeptide into NAM-tetrapeptide, ala
Type: state transition
Pathway Components: NAM-pentapeptide - DacC -> NAM-tetrapeptide + ala
Components:
Function Name Type
catalyzer DacC protein
reactant NAM-pentapeptide simple_molecule
product NAM-tetrapeptide simple_molecule
product ala simple_molecule
ampC_mRNA AmpC
Name: ampC_mRNA -> AmpC
Description: Translation of AmpC
Type: translation
Pathway Components: ampC_mRNA -> AmpC
Components:
Function Name Type
product AmpC protein
reactant ampC_mRNA RNA
AmpC beta-lactam substituted beta-amino acid
Name: beta-lactam -> substituted beta-amino acid
Description: Reaction transforming beta-lactam into substituted beta-amino acid
Type: state transition
Pathway Components: beta-lactam - AmpC -> substituted beta-amino acid
Components:
Function Name Type
catalyzer AmpC protein
reactant beta-lactam simple_molecule
product substituted beta-amino acid simple_molecule



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