RegulonDB RegulonDB

BetI Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
BetA BetB acceptors choline_Ext electron-transfer quinol electron-transfer quinone betIBA BetI BetT betIBA_mRNA choline betaine aldehyde betT_mRNA betaine betaine aldehyde hydrate choline betT BetI A(H2) choline betaine


Gensor Unit       
Name: BetI
Description: Molecular biology level
Detailed: In the absence of choline BetI negatively regulates the expression of genes required for transport and conversion of choline to glycine betaine. Under this condition, BetI repress its own expression and the expression of its regulated genes. In the presence of choline, BetI is modified to BetI-choline, unbinds its target sites enabling its own expression and the expression of its regulated genes.
Less detailed: In the absence of choline, BetI negatively regulates the expression of genes needed for the response to osmotic stress.

Physiology level
Detailed: The presence of choline induces the expression of genes involved with response to osmotic stress. Under this condition the genes necessary for choline uptake and its conversion to glycine betaine, an osmoprotectant, are expressed.
Less detailed: The presence of choline induces the expression of genes needful for transport and conversion of choline to glycine betaine, an osmoprotectant.
Classification:
Groups: Lipid transport and metabolism
Transcription
Energy production and conversion
Cell wall/membrane/envelope biogenesis
Gene Ontology Terms (GO): biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0015871 - choline transport
GO:0019285 - glycine betaine biosynthetic process from choline
GO:0008152 - metabolic process
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0071705 - nitrogen compound transport
Read more >
cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0008802 - betaine-aldehyde dehydrogenase activity
GO:0008812 - choline dehydrogenase activity
GO:0015220 - choline transmembrane transporter activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0042802 - identical protein binding
Read more >
Components:
  Function Name Type
  simple_molecule A(H2) simple_molecule
  protein BetA protein
  protein BetB protein
  protein BetI protein
  complex BetI-choline complex
  protein BetT protein
  simple_molecule acceptors simple_molecule
  gene betIBA gene
  RNA betIBA_mRNA RNA
  gene betT gene
  RNA betT_mRNA RNA
  simple_molecule betaine simple_molecule
  simple_molecule betaine aldehyde simple_molecule
  simple_molecule betaine aldehyde hydrate simple_molecule
  simple_molecule choline simple_molecule
  simple_molecule choline_Ext simple_molecule
  simple_molecule electron-transfer quinol simple_molecule
  simple_molecule electron-transfer quinone simple_molecule


Reactions       
Showing 12 reactions
BetI betIBA betIBA_mRNA
Name: betIBA -> betIBA_mRNA
Description: Transcription of transcription unit betIBA. Reaction inhibition by BetI.
Type: transcription
Pathway Components: betIBA - BetI -> betIBA_mRNA
Components:
Function Name Type
inhibitor BetI protein
reactant betIBA gene
product betIBA_mRNA RNA
BetI betT betT_mRNA
Name: betT -> betT_mRNA
Description: Transcription of transcription unit betT. Reaction inhibition by BetI.
Type: transcription
Pathway Components: betT - BetI -> betT_mRNA
Components:
Function Name Type
inhibitor BetI protein
reactant betT gene
product betT_mRNA RNA
choline + BetI BetI-choline
Name: choline + BetI -> BetI-choline
Description: Reaction transforming choline, BetI into BetI-choline
Type: state transition
Pathway Components: choline + BetI -> BetI-choline
Components:
Function Name Type
reactant BetI protein
product BetI-choline complex
reactant choline simple_molecule
betIBA_mRNA BetI
Name: betIBA_mRNA -> BetI
Description: Translation of BetI
Type: translation
Pathway Components: betIBA_mRNA -> BetI
Components:
Function Name Type
product BetI protein
reactant betIBA_mRNA RNA
betIBA_mRNA BetB
Name: betIBA_mRNA -> BetB
Description: Translation of BetB
Type: translation
Pathway Components: betIBA_mRNA -> BetB
Components:
Function Name Type
product BetB protein
reactant betIBA_mRNA RNA
BetB choline betaine aldehyde betaine
Name: betaine aldehyde -> betaine
Description: Reaction transforming betaine aldehyde into betaine
Type: state transition
Pathway Components: betaine aldehyde - BetB - choline -> betaine
Components:
Function Name Type
catalyzer BetB protein
product betaine simple_molecule
reactant betaine aldehyde simple_molecule
inhibitor choline simple_molecule
betIBA_mRNA BetA
Name: betIBA_mRNA -> BetA
Description: Translation of BetA
Type: translation
Pathway Components: betIBA_mRNA -> BetA
Components:
Function Name Type
product BetA protein
reactant betIBA_mRNA RNA
BetA acceptors + choline betaine aldehyde + A(H2)
Name: acceptors + choline -> betaine aldehyde + A(H2)
Description: Reaction transforming acceptors, choline into betaine aldehyde, A(H2)
Type: state transition
Pathway Components: acceptors + choline - BetA -> betaine aldehyde + A(H2)
Components:
Function Name Type
product A(H2) simple_molecule
catalyzer BetA protein
reactant acceptors simple_molecule
product betaine aldehyde simple_molecule
reactant choline simple_molecule
BetA electron-transfer quinone + choline electron-transfer quinol + betaine aldehyde
Name: electron-transfer quinone + choline -> electron-transfer quinol + betaine aldehyde
Description: Reaction transforming electron-transfer quinone, choline into electron-transfer quinol, betaine aldehyde
Type: state transition
Pathway Components: electron-transfer quinone + choline - BetA -> electron-transfer quinol + betaine aldehyde
Components:
Function Name Type
catalyzer BetA protein
product betaine aldehyde simple_molecule
reactant choline simple_molecule
product electron-transfer quinol simple_molecule
reactant electron-transfer quinone simple_molecule
BetA Reactants electron-transfer quinol + betaine
Name: electron-transfer quinone + betaine aldehyde hydrate -> electron-transfer quinol + betaine
Description: Reaction transforming electron-transfer quinone, betaine aldehyde hydrate into electron-transfer quinol, betaine
Type: state transition
Pathway Components: electron-transfer quinone + betaine aldehyde hydrate - BetA -> electron-transfer quinol + betaine
Components:
Function Name Type
catalyzer BetA protein
product betaine simple_molecule
reactant betaine aldehyde hydrate simple_molecule
product electron-transfer quinol simple_molecule
reactant electron-transfer quinone simple_molecule
betT_mRNA BetT
Name: betT_mRNA -> BetT
Description: Translation of BetT
Type: translation
Pathway Components: betT_mRNA -> BetT
Components:
Function Name Type
product BetT protein
reactant betT_mRNA RNA
BetT choline_Ext choline
Name: choline_Ext -> choline
Description: Transport of choline_Ext through a bacterial membrane, leading to the presence of choline inside the cell.
Type: transport
Pathway Components: choline_Ext - BetT -> choline
Components:
Function Name Type
catalyzer BetT protein
product choline simple_molecule
reactant choline_Ext simple_molecule
R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R11 R12



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