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AsnC Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
asnC-mioC_mRNA aspartate asparagine asparagine 5-carboxymethylaminomethyluridine in tRNA 5-aminomethyl-2-thiouridine in tRNA MnmG MnmG asnC phosphate AsnC A(H2) asnC-mioC tRNA uridine34 5-carboxymethylaminomethyl-2-thiouridine in tRNA methylene-H4PteGlu(n) ammonium asnA_mRNA guanosine-triphosphate MnmE asnC_mRNA guanosine-diphosphate MioC tRNA 2-thiouridine34 AsnC diphosphate asnC-mioC-mnmG_mRNA asnA acceptors glycine MnmE AsnA asnC-mioC-mnmG 7,8-dihydrofolate


Gensor Unit       
Name: AsnC
Description: Molecular biology level
Detailed: In the absence of L-asparagine, AsnC negatively regulates its own expression and the expression of genes required for tRNA methylation and positively regulates the expression of genes required for L-asparagine biosynthesis. Under these conditions, AsnC remains unmodified, binds its target sites preventing its own expression and the expression of some of its regulated genes and at other promoters enabling the expression of its regulated gene.
Less detailed: In the absence of L-asparagine, AsnC negatively regulates the expression of genes needed for tRNA methylation and positively regulates the expression of genes necessary for L-asparagine biosynthesis.

Physiology level
Detailed: The presence of L-asparagine induces the expression of genes involved with tRNA methylation and inhibits the expression of genes required for L-asparagine biosynthesis. Under this condition the genes necessary for modification of tRNA uridine to tRNA methyl uridine are expressed, and the genes necessary for conversion of L-aspartate to L-asparagine are not expressed.
Less detailed: The presence of L-asparagine induces the expression of genes needful for modification of uridine tRNA to methyl uridine tRNA, and inhibits the expression of genes required for conversion of L-aspartate to L-asparagine.
Classification:
Groups: Transcription
Energy production and conversion
Amino acid transport and metabolism
Translation, ribosomal structure and biogenesis
Gene Ontology Terms (GO): biological_process GO:0070981 - L-asparagine biosynthetic process
GO:0006529 - asparagine biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0006974 - cellular response to DNA damage stimulus
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0055114 - oxidation-reduction process
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005622 - intracellular anatomical structure
molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0010181 - FMN binding
GO:0016597 - amino acid binding
GO:0004071 - aspartate-ammonia ligase activity
GO:0050660 - flavin adenine dinucleotide binding
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Components:
  Function Name Type
  simple_molecule 5-aminomethyl-2-thiouridine in tRNA simple_molecule
  simple_molecule 5-carboxymethylaminomethyl-2-thiouridine in tRNA simple_molecule
  simple_molecule 5-carboxymethylaminomethyluridine in tRNA simple_molecule
  simple_molecule 7,8-dihydrofolate simple_molecule
  simple_molecule A(H2) simple_molecule
  protein AsnA protein
  protein AsnC protein
  complex AsnC-asparagine complex
  protein MioC protein
  protein MnmE protein
  complex MnmE-MnmG complex
  protein MnmG protein
  simple_molecule acceptors simple_molecule
  simple_molecule ammonium simple_molecule
  gene asnA gene
  RNA asnA_mRNA RNA
  gene asnC gene
  gene asnC-mioC gene
  gene asnC-mioC-mnmG gene
  RNA asnC-mioC-mnmG_mRNA RNA
  RNA asnC-mioC_mRNA RNA
  RNA asnC_mRNA RNA
  simple_molecule asparagine simple_molecule
  simple_molecule aspartate simple_molecule
  simple_molecule diphosphate simple_molecule
  simple_molecule glycine simple_molecule
  simple_molecule guanosine-diphosphate simple_molecule
  simple_molecule guanosine-triphosphate simple_molecule
  simple_molecule methylene-H4PteGlu(n) simple_molecule
  simple_molecule phosphate simple_molecule
  simple_molecule tRNA 2-thiouridine34 simple_molecule
  simple_molecule tRNA uridine34 simple_molecule


Reactions       
Showing 17 reactions
AsnC asnA asnA_mRNA
Name: asnA -> asnA_mRNA
Description: Transcription of transcription unit asnA. Reaction activation by AsnC.
Type: transcription
Pathway Components: asnA - AsnC -> asnA_mRNA
Components:
Function Name Type
activator AsnC protein
reactant asnA gene
product asnA_mRNA RNA
AsnC asnC asnC_mRNA
Name: asnC -> asnC_mRNA
Description: Transcription of transcription unit asnC. Reaction inhibition by AsnC.
Type: transcription
Pathway Components: asnC - AsnC -> asnC_mRNA
Components:
Function Name Type
inhibitor AsnC protein
reactant asnC gene
product asnC_mRNA RNA
AsnC asnC-mioC asnC-mioC_mRNA
Name: asnC-mioC -> asnC-mioC_mRNA
Description: Transcription of transcription unit asnC-mioC. Reaction inhibition by AsnC.
Type: transcription
Pathway Components: asnC-mioC - AsnC -> asnC-mioC_mRNA
Components:
Function Name Type
inhibitor AsnC protein
reactant asnC-mioC gene
product asnC-mioC_mRNA RNA
AsnC asnC-mioC-mnmG asnC-mioC-mnmG_mRNA
Name: asnC-mioC-mnmG -> asnC-mioC-mnmG_mRNA
Description: Transcription of transcription unit asnC-mioC-mnmG. Reaction inhibition by AsnC.
Type: transcription
Pathway Components: asnC-mioC-mnmG - AsnC -> asnC-mioC-mnmG_mRNA
Components:
Function Name Type
inhibitor AsnC protein
reactant asnC-mioC-mnmG gene
product asnC-mioC-mnmG_mRNA RNA
asparagine + AsnC AsnC-asparagine
Name: asparagine + AsnC -> AsnC-asparagine
Description: Reaction transforming asparagine, AsnC into AsnC-asparagine
Type: state transition
Pathway Components: asparagine + AsnC -> AsnC-asparagine
Components:
Function Name Type
reactant AsnC protein
product AsnC-asparagine complex
reactant asparagine simple_molecule
asnC-mioC_mRNA AsnC
Name: asnC-mioC_mRNA -> AsnC
Description: Translation of AsnC
Type: translation
Pathway Components: asnC-mioC_mRNA -> AsnC
Components:
Function Name Type
product AsnC protein
reactant asnC-mioC_mRNA RNA
asnC-mioC_mRNA MioC
Name: asnC-mioC_mRNA -> MioC
Description: Translation of MioC
Type: translation
Pathway Components: asnC-mioC_mRNA -> MioC
Components:
Function Name Type
product MioC protein
reactant asnC-mioC_mRNA RNA
asnC_mRNA AsnC
Name: asnC_mRNA -> AsnC
Description: Translation of AsnC
Type: translation
Pathway Components: asnC_mRNA -> AsnC
Components:
Function Name Type
product AsnC protein
reactant asnC_mRNA RNA
asnC-mioC-mnmG_mRNA AsnC
Name: asnC-mioC-mnmG_mRNA -> AsnC
Description: Translation of AsnC
Type: translation
Pathway Components: asnC-mioC-mnmG_mRNA -> AsnC
Components:
Function Name Type
product AsnC protein
reactant asnC-mioC-mnmG_mRNA RNA
asnC-mioC-mnmG_mRNA MioC
Name: asnC-mioC-mnmG_mRNA -> MioC
Description: Translation of MioC
Type: translation
Pathway Components: asnC-mioC-mnmG_mRNA -> MioC
Components:
Function Name Type
product MioC protein
reactant asnC-mioC-mnmG_mRNA RNA
asnC-mioC-mnmG_mRNA MnmG
Name: asnC-mioC-mnmG_mRNA -> MnmG
Description: Translation of MnmG
Type: translation
Pathway Components: asnC-mioC-mnmG_mRNA -> MnmG
Components:
Function Name Type
product MnmG protein
reactant asnC-mioC-mnmG_mRNA RNA
MnmE + MnmG MnmE-MnmG
Name: MnmE + MnmG -> MnmE-MnmG
Description: Reaction transforming MnmE, MnmG into MnmE-MnmG
Type: state transition
Pathway Components: MnmE + MnmG -> MnmE-MnmG
Components:
Function Name Type
reactant MnmE protein
product MnmE-MnmG complex
reactant MnmG protein
MnmE-MnmG Reactants Products
Name: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA 2-thiouridine34 + acceptors + glycine -> 5-carboxymethylaminomethyl-2-thiouridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate + A(H2)
Description: Reaction transforming guanosine-triphosphate, methylene-H4PteGlu(n), tRNA 2-thiouridine34, acceptors, glycine into 5-carboxymethylaminomethyl-2-thiouridine in tRNA, guanosine-diphosphate , 7,8-dihydrofolate , phosphate , A(H2)
Type: state transition
Pathway Components: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA 2-thiouridine34 + acceptors + glycine - MnmE-MnmG -> 5-carboxymethylaminomethyl-2-thiouridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate + A(H2)
Components: Show/Hide Components Table
MnmE-MnmG Reactants Products
Name: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA uridine34 + acceptors + glycine -> 5-carboxymethylaminomethyluridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate + A(H2)
Description: Reaction transforming guanosine-triphosphate, methylene-H4PteGlu(n), tRNA uridine34, acceptors, glycine into 5-carboxymethylaminomethyluridine in tRNA, guanosine-diphosphate , 7,8-dihydrofolate , phosphate , A(H2)
Type: state transition
Pathway Components: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA uridine34 + acceptors + glycine - MnmE-MnmG -> 5-carboxymethylaminomethyluridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate + A(H2)
Components: Show/Hide Components Table
MnmE-MnmG Reactants Products
Name: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA 2-thiouridine34 + ammonium -> 5-aminomethyl-2-thiouridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate
Description: Reaction transforming guanosine-triphosphate, methylene-H4PteGlu(n), tRNA 2-thiouridine34, ammonium into 5-aminomethyl-2-thiouridine in tRNA, guanosine-diphosphate , 7,8-dihydrofolate , phosphate
Type: state transition
Pathway Components: guanosine-triphosphate + methylene-H4PteGlu(n) + tRNA 2-thiouridine34 + ammonium - MnmE-MnmG -> 5-aminomethyl-2-thiouridine in tRNA + guanosine-diphosphate + 7,8-dihydrofolate + phosphate
Components: Show/Hide Components Table
asnA_mRNA AsnA
Name: asnA_mRNA -> AsnA
Description: Translation of AsnA
Type: translation
Pathway Components: asnA_mRNA -> AsnA
Components:
Function Name Type
product AsnA protein
reactant asnA_mRNA RNA
AsnA asparagine aspartate + ammonium diphosphate + asparagine
Name: aspartate + ammonium -> diphosphate + asparagine
Description: Reaction transforming aspartate, ammonium into diphosphate, asparagine
Type: state transition
Pathway Components: aspartate + ammonium - AsnA - asparagine -> diphosphate + asparagine
Components:
Function Name Type
catalyzer AsnA protein
reactant ammonium simple_molecule
inhibitor asparagine simple_molecule
product asparagine simple_molecule
reactant aspartate simple_molecule
product diphosphate simple_molecule
R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R11 R12 R13 R14 R15 R16 R17



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