RegulonDB RegulonDB

AllS Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
AllS allDCE_mRNA ureidoglycolate allantoin AllS AllC CO2 allantoate AllE (S)-2-ureidoglycine oxalurate ammonium AllD allDCE allantoin


Gensor Unit       
Name: AllS
Description: Molecular biology level
Detailed: In the presence of (S)-allantoin, AllS positively regulates the expression of genes required for allantoin assimilation. Under this condition, AllS is modified to AllS-(S)-allantoin, binds to its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of (S)-allantoin, Alls positively regulates the expression of genes needed for allantoin assimilation.

Physiology level
Detailed: The presence of allantoin induces the expression of genes involved with allantoin assimilation. Under this condition the genes necessary for allantoin degradation to oxalurate with ammonium production are expressed (or induced).
Less detailed: The presence of (S)-allantoin induces the expression of genes needful for allantoin degradation to oxalurate with ammonium production throughout to the process.
Classification:
Groups: Energy production and conversion
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0009442 - allantoin assimilation pathway
GO:0000256 - allantoin catabolic process
GO:0008152 - metabolic process
GO:0055114 - oxidation-reduction process
GO:0006144 - purine nucleobase metabolic process
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0047652 - allantoate deiminase activity
GO:0016787 - hydrolase activity
GO:0016813 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145 - manganese ion binding
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0042803 - protein homodimerization activity
Read more >
Components:
  Function Name Type
  simple_molecule (S)-2-ureidoglycine simple_molecule
  protein AllC protein
  protein AllD protein
  protein AllE protein
  protein AllS protein
  complex AllS-allantoin complex
  simple_molecule CO2 simple_molecule
  gene allDCE gene
  RNA allDCE_mRNA RNA
  simple_molecule allantoate simple_molecule
  simple_molecule allantoin simple_molecule
  simple_molecule ammonium simple_molecule
  simple_molecule oxalurate simple_molecule
  simple_molecule ureidoglycolate simple_molecule


Reactions       
Showing 9 reactions
allantoin + AllS AllS-allantoin
Name: allantoin + AllS -> AllS-allantoin
Description: Reaction transforming allantoin, AllS into AllS-allantoin
Type: state transition
Pathway Components: allantoin + AllS -> AllS-allantoin
Components:
Function Name Type
reactant AllS protein
product AllS-allantoin complex
reactant allantoin simple_molecule
AllS-allantoin allDCE allDCE_mRNA
Name: allDCE -> allDCE_mRNA
Description: Transcription of transcription unit allDCE. Reaction activation by AllS-allantoin.
Type: transcription
Pathway Components: allDCE - AllS-allantoin -> allDCE_mRNA
Components:
Function Name Type
activator AllS-allantoin complex
reactant allDCE gene
product allDCE_mRNA RNA
allDCE_mRNA AllD
Name: allDCE_mRNA -> AllD
Description: Translation of AllD
Type: translation
Pathway Components: allDCE_mRNA -> AllD
Components:
Function Name Type
product AllD protein
reactant allDCE_mRNA RNA
AllD ureidoglycolate oxalurate
Name: ureidoglycolate -> oxalurate
Description: Reaction transforming ureidoglycolate into oxalurate
Type: state transition
Pathway Components: ureidoglycolate - AllD -> oxalurate
Components:
Function Name Type
catalyzer AllD protein
product oxalurate simple_molecule
reactant ureidoglycolate simple_molecule
allDCE_mRNA AllC
Name: allDCE_mRNA -> AllC
Description: Translation of AllC
Type: translation
Pathway Components: allDCE_mRNA -> AllC
Components:
Function Name Type
product AllC protein
reactant allDCE_mRNA RNA
AllC allantoate (S)-2-ureidoglycine + ammonium + CO2
Name: allantoate -> (S)-2-ureidoglycine + ammonium + CO2
Description: Reaction transforming allantoate into (S)-2-ureidoglycine, ammonium , CO2
Type: state transition
Pathway Components: allantoate - AllC -> (S)-2-ureidoglycine + ammonium + CO2
Components:
Function Name Type
product (S)-2-ureidoglycine simple_molecule
catalyzer AllC protein
product CO2 simple_molecule
reactant allantoate simple_molecule
product ammonium simple_molecule
allDCE_mRNA AllE
Name: allDCE_mRNA -> AllE
Description: Translation of AllE
Type: translation
Pathway Components: allDCE_mRNA -> AllE
Components:
Function Name Type
product AllE protein
reactant allDCE_mRNA RNA
AllE (S)-2-ureidoglycine ureidoglycolate + ammonium
Name: (S)-2-ureidoglycine -> ureidoglycolate + ammonium
Description: Reaction transforming (S)-2-ureidoglycine into ureidoglycolate, ammonium
Type: state transition
Pathway Components: (S)-2-ureidoglycine - AllE -> ureidoglycolate + ammonium
Components:
Function Name Type
reactant (S)-2-ureidoglycine simple_molecule
catalyzer AllE protein
product ammonium simple_molecule
product ureidoglycolate simple_molecule
allantoin allantoate
Name: allantoin -> allantoate
Description: Transformation of allantoin into allantoate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: allantoin / allantoate
Components:
Function Name Type
product allantoate simple_molecule
reactant allantoin simple_molecule



RegulonDB