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Ada Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
oxidized ETF a-thymine-in-DNA aidB_mRNA [protein]-S-methyl-L-cysteine ethanal isovaleryl-CoA an-Nsup1sup-methyladenine-in-DNA aidB DNA guanine ada-alkB a modified nucleobase within DNA ada-alkB_mRNA a DNA containing Spmethyl phosphotriester an-iNisup1sup-ethyladenine-in-DNA AidB DNA dcytosine alkA_mRNA dATP alkylated DNA glyoxal methyl base(2) 3-methylcrotonyl-CoA 1iNisup6sup-ethenoadenine-in-DNA DNA adenine Ada DNA 6-O-methylguanine peptide cysteine AlkA reduced ETF 1-methyl-dAMP a DNA without Spmethyl phosphotriester alkA methyl an-Nsup3sup-methylcytosine-in-DNA 1-methyl-dATP AlkB DNA containing an AP site Ada dAMP peptide cysteine peptide cysteine ketoglutarate oxygen formol CO2 succinate formol ketoglutarate CO2 oxygen DNA adenine succinate CO2 oxygen ketoglutarate succinate oxygen ketoglutarate Ada


Gensor Unit       
Name: Ada
Classification:
Groups: Lipid transport and metabolism
Replication, recombination and repair
Gene Ontology Terms (GO): biological_process GO:0006307 - DNA dealkylation involved in DNA repair
GO:0080111 - DNA demethylation
GO:0006281 - DNA repair
GO:0042245 - RNA repair
GO:0006284 - base-excision repair
GO:0006285 - base-excision repair, AP site formation
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0032993 - protein-DNA complex
molecular_function GO:0103053 - 1-ethyladenine demethylase activity
GO:0003677 - DNA binding
GO:0008725 - DNA-3-methyladenine glycosylase activity
GO:0052822 - DNA-3-methylguanine glycosylase activity
GO:0052821 - DNA-7-methyladenine glycosylase activity
GO:0043916 - DNA-7-methylguanine glycosylase activity
GO:0043734 - DNA-N1-methyladenine dioxygenase activity
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Components:
  Function Name Type
  simple_molecule 1-methyl-dAMP simple_molecule
  simple_molecule 1-methyl-dATP simple_molecule
  simple_molecule 1iNisup6sup-ethenoadenine-in-DNA simple_molecule
  simple_molecule 3-methylcrotonyl-CoA simple_molecule
  protein Ada protein
  complex Ada-methyl complex
  protein AidB protein
  protein AlkA protein
  protein AlkB protein
  simple_molecule CO2 simple_molecule
  simple_molecule DNA 6-O-methylguanine simple_molecule
  simple_molecule DNA adenine simple_molecule
  simple_molecule DNA containing an AP site simple_molecule
  simple_molecule DNA dcytosine simple_molecule
  simple_molecule DNA guanine simple_molecule
  simple_molecule [protein]-S-methyl-L-cysteine simple_molecule
  simple_molecule a DNA containing Spmethyl phosphotriester simple_molecule
  simple_molecule a DNA without Spmethyl phosphotriester simple_molecule
  simple_molecule a modified nucleobase within DNA simple_molecule
  simple_molecule a-thymine-in-DNA simple_molecule
  gene ada-alkB gene
  RNA ada-alkB_mRNA RNA
  gene aidB gene
  RNA aidB_mRNA RNA
  gene alkA gene
  RNA alkA_mRNA RNA
  simple_molecule alkylated DNA simple_molecule
  simple_molecule an-Nsup1sup-methyladenine-in-DNA simple_molecule
  simple_molecule an-Nsup3sup-methylcytosine-in-DNA simple_molecule
  simple_molecule an-iNisup1sup-ethyladenine-in-DNA simple_molecule
  simple_molecule base(2) simple_molecule
  simple_molecule dAMP simple_molecule
  simple_molecule dATP simple_molecule
  simple_molecule ethanal simple_molecule
  simple_molecule formol simple_molecule
  simple_molecule glyoxal simple_molecule
  simple_molecule isovaleryl-CoA simple_molecule
  simple_molecule ketoglutarate simple_molecule
  simple_molecule methyl simple_molecule
  simple_molecule oxidized ETF simple_molecule
  simple_molecule oxygen simple_molecule
  simple_molecule peptide cysteine simple_molecule
  simple_molecule reduced ETF simple_molecule
  simple_molecule succinate simple_molecule


Reactions       
Showing 19 reactions
Ada Ada ada-alkB ada-alkB_mRNA
Name: ada-alkB -> ada-alkB_mRNA
Description: Transcription of transcription unit ada-alkB. Reaction activation by Ada. Reaction inhibition by Ada.
Type: transcription
Pathway Components: ada-alkB - Ada - Ada -> ada-alkB_mRNA
Components:
Function Name Type
activator Ada protein
inhibitor Ada protein
reactant ada-alkB gene
product ada-alkB_mRNA RNA
Ada aidB aidB_mRNA
Name: aidB -> aidB_mRNA
Description: Transcription of transcription unit aidB. Reaction activation by Ada.
Type: transcription
Pathway Components: aidB - Ada -> aidB_mRNA
Components:
Function Name Type
activator Ada protein
reactant aidB gene
product aidB_mRNA RNA
Ada alkA alkA_mRNA
Name: alkA -> alkA_mRNA
Description: Transcription of transcription unit alkA. Reaction activation by Ada.
Type: transcription
Pathway Components: alkA - Ada -> alkA_mRNA
Components:
Function Name Type
activator Ada protein
reactant alkA gene
product alkA_mRNA RNA
methyl + Ada Ada-methyl
Name: methyl + Ada -> Ada-methyl
Description: Reaction transforming methyl, Ada into Ada-methyl
Type: state transition
Pathway Components: methyl + Ada -> Ada-methyl
Components:
Function Name Type
reactant Ada protein
product Ada-methyl complex
reactant methyl simple_molecule
aidB_mRNA AidB
Name: aidB_mRNA -> AidB
Description: Translation of AidB
Type: translation
Pathway Components: aidB_mRNA -> AidB
Components:
Function Name Type
product AidB protein
reactant aidB_mRNA RNA
AidB isovaleryl-CoA + oxidized ETF 3-methylcrotonyl-CoA + reduced ETF
Name: isovaleryl-CoA + oxidized ETF -> 3-methylcrotonyl-CoA + reduced ETF
Description: Reaction transforming isovaleryl-CoA, oxidized ETF into 3-methylcrotonyl-CoA, reduced ETF
Type: state transition
Pathway Components: isovaleryl-CoA + oxidized ETF - AidB -> 3-methylcrotonyl-CoA + reduced ETF
Components:
Function Name Type
product 3-methylcrotonyl-CoA simple_molecule
catalyzer AidB protein
reactant isovaleryl-CoA simple_molecule
reactant oxidized ETF simple_molecule
product reduced ETF simple_molecule
ada-alkB_mRNA Ada
Name: ada-alkB_mRNA -> Ada
Description: Translation of Ada
Type: translation
Pathway Components: ada-alkB_mRNA -> Ada
Components:
Function Name Type
product Ada protein
reactant ada-alkB_mRNA RNA
Ada DNA 6-O-methylguanine + peptide cysteine [protein]-S-methyl-L-cysteine + DNA guanine
Name: DNA 6-O-methylguanine + peptide cysteine -> [protein]-S-methyl-L-cysteine + DNA guanine
Description: Reaction transforming DNA 6-O-methylguanine, peptide cysteine into [protein]-S-methyl-L-cysteine, DNA guanine
Type: state transition
Pathway Components: DNA 6-O-methylguanine + peptide cysteine - Ada -> [protein]-S-methyl-L-cysteine + DNA guanine
Components:
Function Name Type
catalyzer Ada protein
reactant DNA 6-O-methylguanine simple_molecule
product DNA guanine simple_molecule
product [protein]-S-methyl-L-cysteine simple_molecule
reactant peptide cysteine simple_molecule
Ada Reactants [protein]-S-methyl-L-cysteine + a-thymine-in-DNA
Name: a modified nucleobase within DNA + peptide cysteine -> [protein]-S-methyl-L-cysteine + a-thymine-in-DNA
Description: Reaction transforming a modified nucleobase within DNA, peptide cysteine into [protein]-S-methyl-L-cysteine, a-thymine-in-DNA
Type: state transition
Pathway Components: a modified nucleobase within DNA + peptide cysteine - Ada -> [protein]-S-methyl-L-cysteine + a-thymine-in-DNA
Components:
Function Name Type
catalyzer Ada protein
product [protein]-S-methyl-L-cysteine simple_molecule
reactant a modified nucleobase within DNA simple_molecule
product a-thymine-in-DNA simple_molecule
reactant peptide cysteine simple_molecule
Ada Reactants Products
Name: a DNA containing Spmethyl phosphotriester + peptide cysteine -> a DNA without Spmethyl phosphotriester + [protein]-S-methyl-L-cysteine
Description: Reaction transforming a DNA containing Spmethyl phosphotriester, peptide cysteine into a DNA without Spmethyl phosphotriester, [protein]-S-methyl-L-cysteine
Type: state transition
Pathway Components: a DNA containing Spmethyl phosphotriester + peptide cysteine - Ada -> a DNA without Spmethyl phosphotriester + [protein]-S-methyl-L-cysteine
Components:
Function Name Type
catalyzer Ada protein
product [protein]-S-methyl-L-cysteine simple_molecule
reactant a DNA containing Spmethyl phosphotriester simple_molecule
product a DNA without Spmethyl phosphotriester simple_molecule
reactant peptide cysteine simple_molecule
ada-alkB_mRNA AlkB
Name: ada-alkB_mRNA -> AlkB
Description: Translation of AlkB
Type: translation
Pathway Components: ada-alkB_mRNA -> AlkB
Components:
Function Name Type
product AlkB protein
reactant ada-alkB_mRNA RNA
AlkB Reactants DNA adenine + succinate + formol + CO2
Name: an-Nsup1sup-methyladenine-in-DNA + ketoglutarate + oxygen -> DNA adenine + succinate + formol + CO2
Description: Reaction transforming an-Nsup1sup-methyladenine-in-DNA, ketoglutarate, oxygen into DNA adenine, succinate , formol , CO2
Type: state transition
Pathway Components: an-Nsup1sup-methyladenine-in-DNA + ketoglutarate + oxygen - AlkB -> DNA adenine + succinate + formol + CO2
Components:
Function Name Type
catalyzer AlkB protein
product CO2 simple_molecule
product DNA adenine simple_molecule
reactant an-Nsup1sup-methyladenine-in-DNA simple_molecule
product formol simple_molecule
reactant ketoglutarate simple_molecule
reactant oxygen simple_molecule
product succinate simple_molecule
AlkB Reactants DNA dcytosine + succinate + formol + CO2
Name: an-Nsup3sup-methylcytosine-in-DNA + ketoglutarate + oxygen -> DNA dcytosine + succinate + formol + CO2
Description: Reaction transforming an-Nsup3sup-methylcytosine-in-DNA, ketoglutarate, oxygen into DNA dcytosine, succinate , formol , CO2
Type: state transition
Pathway Components: an-Nsup3sup-methylcytosine-in-DNA + ketoglutarate + oxygen - AlkB -> DNA dcytosine + succinate + formol + CO2
Components:
Function Name Type
catalyzer AlkB protein
product CO2 simple_molecule
product DNA dcytosine simple_molecule
reactant an-Nsup3sup-methylcytosine-in-DNA simple_molecule
product formol simple_molecule
reactant ketoglutarate simple_molecule
reactant oxygen simple_molecule
product succinate simple_molecule
AlkB Reactants DNA adenine + succinate + ethanal + CO2
Name: an-iNisup1sup-ethyladenine-in-DNA + ketoglutarate + oxygen -> DNA adenine + succinate + ethanal + CO2
Description: Reaction transforming an-iNisup1sup-ethyladenine-in-DNA, ketoglutarate, oxygen into DNA adenine, succinate , ethanal , CO2
Type: state transition
Pathway Components: an-iNisup1sup-ethyladenine-in-DNA + ketoglutarate + oxygen - AlkB -> DNA adenine + succinate + ethanal + CO2
Components:
Function Name Type
catalyzer AlkB protein
product CO2 simple_molecule
product DNA adenine simple_molecule
reactant an-iNisup1sup-ethyladenine-in-DNA simple_molecule
product ethanal simple_molecule
reactant ketoglutarate simple_molecule
reactant oxygen simple_molecule
product succinate simple_molecule
AlkB Reactants DNA adenine + succinate + glyoxal + CO2
Name: 1iNisup6sup-ethenoadenine-in-DNA + ketoglutarate + oxygen -> DNA adenine + succinate + glyoxal + CO2
Description: Reaction transforming 1iNisup6sup-ethenoadenine-in-DNA, ketoglutarate, oxygen into DNA adenine, succinate , glyoxal , CO2
Type: state transition
Pathway Components: 1iNisup6sup-ethenoadenine-in-DNA + ketoglutarate + oxygen - AlkB -> DNA adenine + succinate + glyoxal + CO2
Components:
Function Name Type
reactant 1iNisup6sup-ethenoadenine-in-DNA simple_molecule
catalyzer AlkB protein
product CO2 simple_molecule
product DNA adenine simple_molecule
product glyoxal simple_molecule
reactant ketoglutarate simple_molecule
reactant oxygen simple_molecule
product succinate simple_molecule
AlkB 1-methyl-dATP + ketoglutarate + oxygen succinate + formol + dATP + CO2
Name: 1-methyl-dATP + ketoglutarate + oxygen -> succinate + formol + dATP + CO2
Description: Reaction transforming 1-methyl-dATP, ketoglutarate, oxygen into succinate, formol , dATP , CO2
Type: state transition
Pathway Components: 1-methyl-dATP + ketoglutarate + oxygen - AlkB -> succinate + formol + dATP + CO2
Components:
Function Name Type
reactant 1-methyl-dATP simple_molecule
catalyzer AlkB protein
product CO2 simple_molecule
product dATP simple_molecule
product formol simple_molecule
reactant ketoglutarate simple_molecule
reactant oxygen simple_molecule
product succinate simple_molecule
AlkB ketoglutarate + 1-methyl-dAMP + oxygen succinate + formol + dAMP + CO2
Name: ketoglutarate + 1-methyl-dAMP + oxygen -> succinate + formol + dAMP + CO2
Description: Reaction transforming ketoglutarate, 1-methyl-dAMP, oxygen into succinate, formol , dAMP , CO2
Type: state transition
Pathway Components: ketoglutarate + 1-methyl-dAMP + oxygen - AlkB -> succinate + formol + dAMP + CO2
Components:
Function Name Type
reactant 1-methyl-dAMP simple_molecule
catalyzer AlkB protein
product CO2 simple_molecule
product dAMP simple_molecule
product formol simple_molecule
reactant ketoglutarate simple_molecule
reactant oxygen simple_molecule
product succinate simple_molecule
alkA_mRNA AlkA
Name: alkA_mRNA -> AlkA
Description: Translation of AlkA
Type: translation
Pathway Components: alkA_mRNA -> AlkA
Components:
Function Name Type
product AlkA protein
reactant alkA_mRNA RNA
AlkA alkylated DNA DNA containing an AP site + base(2)
Name: alkylated DNA -> DNA containing an AP site + base(2)
Description: Reaction transforming alkylated DNA into DNA containing an AP site, base(2)
Type: state transition
Pathway Components: alkylated DNA - AlkA -> DNA containing an AP site + base(2)
Components:
Function Name Type
catalyzer AlkA protein
product DNA containing an AP site simple_molecule
reactant alkylated DNA simple_molecule
product base(2) simple_molecule



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