RegulonDB RegulonDB 11.0: Operon Form
   

cspE operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: cspE
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: cspE
Gene(s): cspE   Genome Browser M3D Gene expression COLOMBOS
Note(s): The mRNA produced by the cspE gene has been observed mainly in the poles of the cell Kannaiah S, Livny J, Amster-Choder O,2019.
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Uppal S., et al., 2008
Promoter
Name: cspEp1
+1: 657147
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 145
Sequence: gtactttgcctggatgcgctttcagttttgagacaaatgaagttttagtaacttctttaaAatcaatagctaaaataagta
                            -35                  -10        +1                   
Evidence: [AIPP]
[ICWHO]
Reference(s): [2] Huerta AM., et al., 2003
[1] Uppal S., et al., 2008
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal DinJ-YafQ repressor cspEp1 657096 657112 -43.5 tgtactttgcCTGGATGCGCTTTCAGTtttgagacaa nd [GEA], [BPP], [SM] [3]


Transcription unit          
Name: cspE
Gene(s): cspE   Genome Browser M3D Gene expression COLOMBOS
Note(s): The cspE gene is constitutively expressed at 37°C and is induced about threefold at both the transcript and the protein levels in response to cold shock. cspE is also regulated at the posttranscriptional level by RNAse E and temperature-dependent UTR secondary structures Uppal S,2008.
Previously, cspE was shown to be involved in the regulation of the expression of some cold-induced genes Phadtare S, Tadigotla V, Shin WH, Sengupta A, Severinov K,2006; in particular, it might play an important role in the early stages of cold adaptation Uppal S,2008.
The mRNA produced by the cspE gene has been observed mainly in the poles of the cell Kannaiah S, Livny J, Amster-Choder O,2019.
Evidence: [ICWHO] Inferred computationally without human oversight
[LTED] Length of transcript experimentally determined
Reference(s): [1] Uppal S., et al., 2008
Promoter
Name: cspEp2
+1: 657250
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 42
Sequence: tatcactttttagtaaagttacactggacaaagcgtaccacaattggtgtactggtaaccGacacagcatttgtgtctatt
                         -35                      -10       +1                   
Note(s): cspEp2 has two transcription start sites (656472 and 656473, absolute position in the genome), which were identified at 37 and 15°C Uppal S,2008.
Evidence: [AIPP]
[ICWHO]
[TIM]
Reference(s): [2] Huerta AM., et al., 2003
[1] Uppal S., et al., 2008
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cyclic-AMP activator cspEp2 657178 657200 -61.5 acatcaaaaaTAACGCGACTTTTATCACTTTTTagtaaagtta nd [GEA], [APIORCISFBSCS], [BPP], [SM] [4]





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