RegulonDB RegulonDB 10.9: Operon Form

gcvA operon and associated TUs in Escherichia coli K-12 genome

Name: gcvA
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Name: gcvA
Synonym(s): OP00233
Gene(s): gcvA   Genome Browser M3D Gene expression COLOMBOS
Note(s): The protein H-NS positively regulates gcv operon expression, but this regulation seems to be indirect 11114904 Overproduction of BglG in stationary phase brings about downregulation of both gcvA and gcvB Shukla S,2019
The half-life of the gcvA mRNA is reduced by the RNA-binding protein BglG during stationary phase Harwani D,2012
Reference(s): [1] Jin T., et al., 1995
Name: gcvAp
+1: 2942639
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 72
Sequence: aagtgccgccactataggtatttgctggtagaagctcaacggacaatttataatggctcaGattaaaaaaactaataggtt
                      -35                        -10        +1                   
Note(s): This promoter has another putative transcription start site. The two transcription start sites are spaced only 1 nt apart.
Evidence: [HIPP]
Reference(s): [2] Huerta AM., et al., 2003
[3] Wilson RL., et al., 1994
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal GcvA repressor gcvAp 2942624 2942638 9.0 taatggctcaGATTAAAAAAACTAATaggttacata nd [APIORCISFBSCS], [BCE], [GEA], [SM] [3], [4], [5], [6], [7]
proximal GcvA repressor gcvAp 2942646 2942660 -14.0 tagaagctcaACGGACAATTTATAATggctcagatt nd [AIBSCS], [APIORCISFBSCS], [BCE], [BPP], [GEA], [IC] [3], [4], [5], [6], [7]