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| Operon |  |
|---|---|
| Name: | osmC |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | osmC | |||||||||
| Gene(s): | osmC Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | The osmC gene is upregulated by long-term (8 to 12 h) exposure of E. coli to some biocides Merchel Piovesan Pereira B, Wang X, Tagkopoulos I,2020. The osmC gene is upregulated at 1.25 M MgSO4 (Magnesium Sulfate); this upregulatioin may arise from increased production of RpoS and the transcription of osmC from osmCp2, or in a RpoS-independent way from osmCp1 during the exponential growth phase. Another possibility is the downregulation of H-NS and LrP or decreased binding affinities to both promoters Nepal S, Kumar P,2020 A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for osmC . This structure could regulate the expression of the gene, as observed for hemL gene expression Shao X, Zhang W, Umar MI, Wong HY, Seng Z, Xie Y, Zhang Y, Yang L, Kwok CK, Deng X,2020. |
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| Evidence: | [AISGDTU] Automated inference that a single-gene directon is a transcription unit | |||||||||
| Promoter | ||||||||||
| Name: | osmCp1 | |||||||||
| +1: | 1556596 | |||||||||
| Sigma Factor: | Sigma70 Sigmulon | |||||||||
| Distance from start of the gene: | 29 | |||||||||
| Sequence: |
gccggattttattcggaatatcctgcttatcctcgtgctgtttctcacgtagtctataatTtcctttttaagcccacagga -35 -10 +1 |
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| Evidence: |
[HIPP] [ICWHO] [RS-EPT-CBR] [TIM] |
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| Reference(s): |
[1] Bouvier J., et al., 1998 [2] Gordia S., et al., 1996 [3] Gutierrez C., et al., 1991 [4] Huerta AM., et al., 2003 [5] Salgado H, et al., 2012 |
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| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | Lrp | repressor | osmCp1 | 1556537 | 1556551 | -52.0 | aatattttcgCCGGATTTTATTCGGaatatcctgc | nd | [GEA], [APIORCISFBSCS], [BPP], [SM] | [1] |
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | RcsB-phosphorylated | activator | osmCp1 | 1556548 | 1556561 | -41.5 | cggattttatTCGGAATATCCTGCttatcctcgt | nd | [GEA], [BPP], [SM] | [8], [9] |
| Name: | osmC | |||||||||
| Gene(s): | osmC Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | The osmC gene is upregulated by long-term (8 to 12 h) exposure of E. coli to some biocides Merchel Piovesan Pereira B, Wang X, Tagkopoulos I,2020. The osmC gene is upregulated at 1.25 M MgSO4 (Magnesium Sulfate); this upregulatioin may arise from increased production of RpoS and the transcription of osmC from osmCp2, or in a RpoS-independent way from osmCp1 during the exponential growth phase. Another possibility is the downregulation of H-NS and LrP or decreased binding affinities to both promoters Nepal S, Kumar P,2020 A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for osmC . This structure could regulate the expression of the gene, as observed for hemL gene expression Shao X, Zhang W, Umar MI, Wong HY, Seng Z, Xie Y, Zhang Y, Yang L, Kwok CK, Deng X,2020. |
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| Evidence: | [AISGDTU] Automated inference that a single-gene directon is a transcription unit | |||||||||
| Promoter | ||||||||||
| Name: | osmCp2 | |||||||||
| +1: | 1556606 | |||||||||
| Sigma Factor: | Sigma38 Sigmulon | |||||||||
| Distance from start of the gene: | 19 | |||||||||
| Sequence: |
attcggaatatcctgcttatcctcgtgctgtttctcacgtagtctataatttcctttttaAgcccacaggagagcaacaat -35 -10 +1 |
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| Evidence: |
[APIORCISFBSCS] [HIPP] [ICWHO] [TIM] |
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| Reference(s): |
[10] Bordes P., et al., 2000 [1] Bouvier J., et al., 1998 [2] Gordia S., et al., 1996 [3] Gutierrez C., et al., 1991 [4] Huerta AM., et al., 2003 |
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| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | Lrp | activator | osmCp2 | 1556537 | 1556551 | -62.0 | aatattttcgCCGGATTTTATTCGGaatatcctgc | nd | [GEA], [APIORCISFBSCS], [BPP], [SM] | [1] |
| Reference(s) |
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|---|---|
[HIPP] Human inference of promoter position