RegulonDB RegulonDB 10.9: Operon Form
   

metK operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: metK
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: metK
Gene(s): metK   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: metKp2
+1: 3086577
Sigma Factor: Sigma38 Sigmulon
Distance from start of the gene: 129
Sequence: gattcaaaaaaaagtggaaatagggtgaagaattgacctaaaatagccatccagatgttaAtccatccataccgattaaca
Evidence: [HIPP]
[TIM]
Reference(s): [1] Seo SW., et al., 2015
[2] Wei Y., et al., 2002
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP repressor metKp2 3086506 3086527 -60.5 gtttttaacaGAATGAGACACGATTCAAAAAAAagtggaaata nd [AIBSCS], [GEA] [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MetJ-S-adenosyl-L-methionine1 repressor metKp2 3086555 3086570 -14.5 agaattgaccTAAAATAGCCATCCAGAtgttaatcca nd [AIBSCS] [4]
proximal MetJ-S-adenosyl-L-methionine2 repressor metKp2 3086567 3086582 -2.5 aaatagccatCCAGATGTTAATCCATCcataccgatt nd [AIBSCS] [4]
Note(s): 1The regulatory effect of MetJ on the promoter metKp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: the protein's binding site is very close to the promoter, and MetJ is known to act, so far without exceptions, as a negative regulator.
2The regulatory effect of MetJ on the promoter metKp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: the protein's binding site is very close to the promoter, and MetJ is known to act, so far without exceptions, as a negative regulator.2The regulatory effect of MetJ on the promoter metKp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: the protein's binding site is very close to the promoter, and MetJ is known to act, so far without exceptions, as a negative regulator.
3The regulatory effect of MetJ on the promoter metKp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: the protein's binding site is very close to the promoter, and MetJ is known to act, so far without exceptions, as a negative regulator.


Transcription unit          
Name: metK
Gene(s): metK   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: metKp
+1: 3086577
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 129
Sequence: gattcaaaaaaaagtggaaatagggtgaagaattgacctaaaatagccatccagatgttaAtccatccataccgattaaca
                                 -35                  -10   +1                   
Evidence: [HIPP]
[ICWHO]
[TIM]
Reference(s): [5] Huerta AM., et al., 2003
[1] Seo SW., et al., 2015
[2] Wei Y., et al., 2002
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP repressor metKp 3086506 3086527 -60.5 gtttttaacaGAATGAGACACGATTCAAAAAAAagtggaaata nd [AIBSCS], [GEA] [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MetJ-S-adenosyl-L-methionine1 repressor metKp 3086555 3086570 -14.5 agaattgaccTAAAATAGCCATCCAGAtgttaatcca nd [AIBSCS] [4]
proximal MetJ-S-adenosyl-L-methionine2 repressor metKp 3086567 3086582 -2.5 aaatagccatCCAGATGTTAATCCATCcataccgatt nd [AIBSCS] [4]
Note(s): 1The regulatory effect of MetJ on the promoter metKp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: the protein's binding site is very close to the promoter, and MetJ is known to act, so far without exceptions, as a negative regulator.
2The regulatory effect of MetJ on the promoter metKp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: the protein's binding site is very close to the promoter, and MetJ is known to act, so far without exceptions, as a negative regulator.2The regulatory effect of MetJ on the promoter metKp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: the protein's binding site is very close to the promoter, and MetJ is known to act, so far without exceptions, as a negative regulator.
3The regulatory effect of MetJ on the promoter metKp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: the protein's binding site is very close to the promoter, and MetJ is known to act, so far without exceptions, as a negative regulator.





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