RegulonDB RegulonDB 10.9: Operon Form
   

exbBD operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: exbBD
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: exbD
Gene(s): exbD   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Ahmer BM., et al., 1995
[2] Eick-Helmerich K., et al., 1989
Promoter
Name: exbDp
+1: 3151390
Distance from start of the gene: 147
Sequence: ttagcaacggcaatcggcctcgtggcagcgattcctgcggtcgttatctataacgtatttGcacgccagattggcggcttt
Note(s): We assigned a putative transcription start site to this promoter based on the observation that the majority of the promoters, whose transcription start sites were determined experimentally, present a distance of 6 nucleotides between the transcription start site and the -10 box.
Evidence: [HIPP]
Reference(s): [2] Eick-Helmerich K., et al., 1989
Terminator(s)
Type: rho-independent
Sequence: gttaaaaaaaTGCCCGGTTGTGAAAAGCAACCGGGcatcattgtg
Reference(s): [2] Eick-Helmerich K., et al., 1989
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal Fur-Fe2+1 repressor exbDp 3151427 3151445 -46.0 gctctgttagCAACGGCAATCGGCCTCGTGgcagcgattc nd [APIORCISFBSCS] [2]
Note(s): 1The regulatory effect of Fur on the promoter exbDp is as of yet not known. However, we assigned a negative effect to this regulatory interaction based on the fact that the protein Fur is known to act, so far without exceptions, as a negative regulator.1The regulatory effect of Fur on the promoter exbDp is as of yet not known. However, we assigned a negative effect to this regulatory interaction based on the fact that the protein Fur is known to act, so far without exceptions, as a negative regulator.


Transcription unit          
Name: exbBD
Gene(s): exbD, exbB   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
[ITCR] Inferred through co-regulation
Reference(s): [1] Ahmer BM., et al., 1995
[2] Eick-Helmerich K., et al., 1989
Promoter
Name: exbBp
+1: 3152014
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 30
Sequence: atgcaaatagtaatgagaacgactatcaattcgacgtcgttttgatattattatgcgcagAttttgtgacttgcgtcctgg
                         -35                  -10           +1                   
Note(s): We assigned a putative transcription start site to this promoter based on the observation that the majority of the promoters, whose transcription start sites were determined experimentally, present a distance of 6 nucleotides between the transcription start site and the -10 box.
Evidence: [HIPP]
[ICWHO]
Reference(s): [2] Eick-Helmerich K., et al., 1989
[3] Huerta AM., et al., 2003
Terminator(s)
Type: rho-independent
Sequence: gttaaaaaaaTGCCCGGTTGTGAAAAGCAACCGGGcatcattgtg
Reference(s): [2] Eick-Helmerich K., et al., 1989
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal Fur-Fe2+1 repressor exbBp 3152045 3152063 -40.0 atgcaaatagTAATGAGAACGACTATCAATtcgacgtcgt nd [APIORCISFBSCS], [BPP] [2], [4]
proximal Fur-Fe2+ repressor exbBp 3152051 3152069 -46.0 ggcagtatgcAAATAGTAATGAGAACGACTatcaattcga nd [AIBSCS] nd
Note(s): 1The regulatory effect of Fur on the promoter exbBp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: (1) the protein's binding site overlaps the -35 box of the promoter; and (2) Fur is known to act, so far without exceptions, as a negative regulator.
2The regulatory effect of Fur on the promoter exbBp is not yet known. However, we assigned a negative effect to this regulatory interaction based on two facts: (1) the protein's binding site overlaps the -35 box of the promoter; and (2) Fur is known to act, so far without exceptions, as a negative regulator.





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