RegulonDB RegulonDB 10.9: Operon Form
   

trxC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: trxC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: trxC
Gene(s): trxC   Genome Browser M3D Gene expression COLOMBOS
Note(s): The transcription of the gene trxC is enhanced under high oxygen saturation (300%) in the absence of the superoxide dismutase proteins SodA and SodB Baez A,2013
Sulfane sulfur modifies OxyR at Cys199 to form a protein persulfide that in turn activates the expression of grxA, trxC, and katG promoters under both aerobic and anaerobic conditions 31421411
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: trxCp
+1: 2718675
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 60
Sequence: atcatacctattgaataaaacagattgttgtctggaacaatgtccccgataatatgtaacAtattagaaacataccggcgt
                            -35                   -10       +1                   
Evidence: [HIPP]
[ICWHO]
[TIM]
Reference(s): [1] Huerta AM., et al., 2003
[2] Ritz D., et al., 2000
TF binding sites (TFBSs)
[OxyR,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal OxyR activator trxCp 2718610 2718626 -57.0 ccaaagcctgCGACTATCATACCTATTGaataaaacag [APIORCISFBSCS], [BPP], [CEEUMA], [GEA], [IHBCE], [RSE] [2], [3]
proximal OxyR activator trxCp 2718632 2718648 -35.0 ctattgaataAAACAGATTGTTGTCTGGaacaatgtcc [APIORCISFBSCS], [BPP], [GEA] [2]


Evidence    

 [HIPP] Human inference of promoter position

 [ICWHO] Inferred computationally without human oversight

 [TIM] Transcription initiation mapping

 [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [BPP] Binding of purified proteins

 [CEEUMA] ChIP-exo evidence used in manual assertion

 [GEA] Gene expression analysis

 [IHBCE] Inferred by a human based on computational evidence

 [RSE] RNA-seq evidence


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Ritz D., Patel H., Doan B., Zheng M., Aslund F., Storz G., Beckwith J., 2000, Thioredoxin 2 is involved in the oxidative stress response in Escherichia coli., J Biol Chem 275(4):2505-12

 [3] Seo SW., Kim D., Szubin R., Palsson BO., 2015, Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655., Cell Rep 12(8):1289-99

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