RegulonDB RegulonDB 10.10: Operon Form
   

cueO operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: cueO
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: cueO
Gene(s): cueO   Genome Browser M3D Gene expression COLOMBOS
Promoter
Name: cueOp
+1: 137045
Distance from start of the gene: 38
Sequence: tcgattaaattgtgtctgcggcttgaccttcccgtaaggggaaggactatgctcaacgttTgattttgtttcgcctgctta
Evidence: [HIPP]
[RS-EPT-CBR]
Reference(s): [1] Outten FW., et al., 2000
[2] Salgado H, et al., 2012
TF binding sites (TFBSs)
[CueR,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CueR-Cu+ activator cueOp 137011 137029 -25.0 tgcggcttgaCCTTCCCGTAAGGGGAAGGactatgctca nd [GEA], [APIORCISFBSCS], [BPP] [1], [3], [4]


Evidence    

 [HIPP] Human inference of promoter position

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [GEA] Gene expression analysis

 [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [BPP] Binding of purified proteins


Reference(s)    

 [1] Outten FW., Outten CE., Hale J., O'Halloran TV., 2000, Transcriptional activation of an Escherichia coli copper efflux regulon by the chromosomal MerR homologue, cueR., J Biol Chem 275(40):31024-9

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Xu Z., Wang P., Wang H., Yu ZH., Au-Yeung HY., Hirayama T., Sun H., Yan A., 2019, Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli., J Biol Chem 294(45):16978-16991

 [4] Yamamoto K., Ishihama A., 2005, Transcriptional response of Escherichia coli to external copper., Mol Microbiol 56(1):215-27

RegulonDB