RegulonDB RegulonDB 10.8: Operon Form
   

mutS operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: mutS
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: mutS
Gene(s): mutS   Genome Browser M3D Gene expression COLOMBOS
Note(s): Transcription of the mutS gene might be negatively regulated by σ38 through an intermediate regulator, as was shown in Tsui HC,1997 On other hand Hfq negatively regulates mutS expression, destabilizing its transcription during exponential growth.
Evidence: [BTEI] Boundaries of transcription experimentally identified
[CV(LTED/PM)] cross validation(LTED/PM)
[CV(PET/PM)] cross validation(PET/PM)
[LTED] Length of transcript experimentally determined
[PM] Polar mutation
Reference(s): [1] Tsui HC., et al., 1997
Promoter
Name: mutSp
+1: 2857019
Sigma Factor: Sigma38 Sigmulon
Distance from start of the gene: 74
Sequence: accagcatcaagaactcgccgttcgcttcttcccctgaaatgattaactccggtatcatgTgcgccttatgtgattacaac
                              -35                -10        +1                   
Evidence: [TIM]
Reference(s): [1] Tsui HC., et al., 1997


Evidence    

 [TIM] Transcription initiation mapping


Reference(s)    

 [1] Tsui HC., Feng G., Winkler ME., 1997, Negative regulation of mutS and mutH repair gene expression by the Hfq and RpoS global regulators of Escherichia coli K-12., J Bacteriol 179(23):7476-87

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