RegulonDB RegulonDB 10.10: Operon Form
   

metZWV operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: metZWV
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: metZWV
Synonym(s): metZ
Gene(s): metZ, metW, metV   Genome Browser M3D Gene expression COLOMBOS
Note(s): metZWV expression is inhibited by ppGpp Nagase T,1988.
Evidence: [BTEI] Boundaries of transcription experimentally identified
[LTED] Length of transcript experimentally determined
Reference(s): [1] Nagase T., et al., 1988
Promoter
Name: metZp
+1: 2947382
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 5
Sequence: tccgtgatcggggtaaaaaaaaggttgcatgaaaacgcgagcggagtatagtgcgcatccAcggacgcggggtggagcagc
                         -35                   -10          +1                   
Evidence: [HIPP]
[ICWHO]
[IHBCE]
[TIM]
Reference(s): [2] Huerta AM., et al., 2003
[1] Nagase T., et al., 1988
Terminator(s)
Type: rho-independent
Sequence: ccaattattgAACACCCTAACGGGTGTTTTTTTGTTTctggtctccc
Reference(s): [1] Nagase T., et al., 1988
[3] Peters JM., et al., 2009
[4] Zuker M. 2003
Type: rho-independent
Sequence: ccataaaaaaGCGCCATTCAGCGCCTTTTTAtcatcccctt
Reference(s): [1] Nagase T., et al., 1988
Allosteric regulation of RNA-polymerase
  Regulator Function Promoter target of RNApol Growth Conditions Note Evidence Reference
  ppGpp inhibition metZp nd   [IDA]
[IHBCE] 		[1]
Evidence: [IDA] Inferred from direct assay
[IHBCE] Inferred by a human based on computational evidence
Reference(s): [1] Nagase T., et al., 1988


Evidence    

 [HIPP] Human inference of promoter position

 [ICWHO] Inferred computationally without human oversight

 [IHBCE] Inferred by a human based on computational evidence

 [TIM] Transcription initiation mapping


Reference(s)    

 [1] Nagase T., Ishii S., Imamoto F., 1988, Differential transcriptional control of the two tRNA(fMet) genes of Escherichia coli K-12., Gene 67(1):49-57

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Peters JM., Mooney RA., Kuan PF., Rowland JL., Keles S., Landick R., 2009, Rho directs widespread termination of intragenic and stable RNA transcription., Proc Natl Acad Sci U S A 106(36):15406-11

 [4] Zuker M., 2003, Mfold web server for nucleic acid folding and hybridization prediction., Nucleic Acids Res 31(13):3406-15

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