RegulonDB RegulonDB 10.8: Operon Form

leuQPV operon and associated TUs in Escherichia coli K-12 genome

Name: leuQPV
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Name: leuQPV
Synonym(s): leuQ
Gene(s): leuV, leuP, leuQ   Genome Browser M3D Gene expression COLOMBOS
Note(s): It is very probable that both valVW and leuQPV operons terminate in a Rho-dependent fashion, since the downstream sequences do not contain any recognizable Rho-independent transcription terminator structures Mohanty BK,2007.
A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for leuP . This structure could regulate the expression of the gene, as observed for hemL gene expression 31964733.
Evidence: [BTEI] Boundaries of transcription experimentally identified
[LTED] Length of transcript experimentally determined
Reference(s): [1] Mohanty BK., et al., 2007
Name: leuQp
+1: 4606432
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 31
Sequence: cacctctgtcgataattaactattgacgaaaagctgaaaaccactagaatgcgcctccgtGgtagcaattctttttaagaa
                       -35                   -10            +1                   
Evidence: [HIPP]
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal Fis activator leuQp 4606498 4606512 -73.0 gtttcctgatGGACATTTTTCCAGCaattacacct nd [APIORCISFBSCS], [BCE], [CV(GEA/ROMA)], [GEA], [IHBCE] [2], [3]

Transcription unit       
Name: leuV
Gene(s): leuV   Genome Browser M3D Gene expression COLOMBOS
Note(s): Based on results of nuclease protection and primer extension assays, leuV, argT, metT, and leuX were determined to be involved in the stringent response induced by serine hydroxamate Rowley KB,1993.