RegulonDB RegulonDB 10.9: Operon Form
   

dadAX operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: dadAX
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: dadAX
Gene(s): dadA, dadX   Genome Browser M3D Gene expression COLOMBOS
Note(s): The transcript of dadAX is decreased after σE induction, as observed in high-throughput analysis of gene expression Lacoux C,2020.
dadAX operon expression is upregulated upon L-valine addition (isoleucine starvation) in the cellular growth medium 32211022.

A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for dadA . This structure could regulate the expression of the gene, as observed for hemL gene expression 31964733.
Evidence: [ITCR] Inferred through co-regulation
[PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Lobocka M., et al., 1994
[2] Wild J., et al., 1985
Promoter
Name: dadAp1
+1: 1237509
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 62
Sequence: tcagggagatgtgagccagctcaccataaaaaagccgcatgttgaataatattttcaactGagttatcaagatgtgattag
                          -35                     -10       +1                   
Evidence: [ICWHO]
[TIM]
Reference(s): [3] Huerta AM., et al., 2003
[4] Mathew E., et al., 1996
[5] Zhi J., et al., 1999
[6] Zhi J., et al., 1998
TF binding sites (TFBSs)
[CRP,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator dadAp1 1237455 1237477 -43.5 agagtcagggAGATGTGAGCCAGCTCACCATAAaaaagccgca nd [APIORCISFBSCS], [BPP], [GEA] [4], [5], [6]
proximal CRP-cAMP activator dadAp1 1237518 1237539 20.5 tgagttatcaAGATGTGATTAGATTATTATTCTtttactgtat nd [APIORCISFBSCS], [BPP], [GEA] [4], [5]
[CRP,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP repressor dadAp1 1237518 1237539 20.5 tgagttatcaAGATGTGATTAGATTATTATTCTtttactgtat nd [APIORCISFBSCS], [BPP], [GEA] [4], [5]
[Lrp,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote Lrp1 repressor dadAp1 1237252 1237266 -250.0 acgcgcacctCATTGTTGTCGGCGCTctctgtgtgg nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp2 repressor dadAp1 1237277 1237291 -225.0 tctctgtgtgGAGCACCTCATTTCAAgcatagaaca nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp3 repressor dadAp1 1237325 1237339 -177.0 cgcgtcgccgGAGAATTTTTTTCTTTgcgatttctt nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
remote Lrp4 repressor dadAp1 1237356 1237370 -146.0 ttcttattatCAGAGTGCCACTAATCcgcttctgaa nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp5 repressor dadAp1 1237382 1237396 -120.0 cgcttctgaaCGGAATTTTATGCTGGataaaaaggg nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
proximal Lrp6 repressor dadAp1 1237412 1237426 -90.0 aaagggcgttCAGCAGGAGATACTAAagacgccata nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
proximal Lrp7 repressor dadAp1 1237450 1237464 -52.0 gccgcagagtCAGGGAGATGTGAGCCagctcaccat nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
proximal Lrp8 repressor dadAp1 1237495 1237509 -7.0 gcatgttgaaTAATATTTTCAACTGAgttatcaaga nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
proximal Lrp9 repressor dadAp1 1237527 1237541 26.0 aagatgtgatTAGATTATTATTCTTTtactgtatct nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
remote Lrp10 repressor dadAp1 1237574 1237588 73.0 agtggctatgCGAGTTGTCATACTGGgaagtggtgt nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp11 repressor dadAp1 1237596 1237610 95.0 ctgggaagtgGTGTGGTAGGCGTTGCcagcgcctgg nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
Note(s): 1Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
2Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
3Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
4Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
5Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
6Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
7Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
8Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
9Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
10Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
11Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,20191Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
2Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
3Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
4Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
5Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
6Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
7Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
9Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
12Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
13Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
14Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019


Transcription unit          
Name: dadAX
Synonym(s): dad
Gene(s): dadA, dadX   Genome Browser M3D Gene expression COLOMBOS
Note(s): The transcript of dadAX is decreased after σE induction, as observed in high-throughput analysis of gene expression Lacoux C,2020.
dadAX operon expression is upregulated upon L-valine addition (isoleucine starvation) in the cellular growth medium 32211022.
A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for dadA . This structure could regulate the expression of the gene, as observed for hemL gene expression 31964733.
Evidence: [ITCR] Inferred through co-regulation
[PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Lobocka M., et al., 1994
[2] Wild J., et al., 1985
Promoter
Name: dadAp2
+1: 1237525
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 46
Sequence: cagctcaccataaaaaagccgcatgttgaataatattttcaactgagttatcaagatgtgAttagattattattcttttac
                          -35                       -10     +1                   
Note(s): This is the +1 in induced cells; in uninduced cells transcription starts 5 bp dowstream: GATTAGA-(here). Several regions with significant similarity to known σ70 promoter sequences were found. Previous genetic studies identified a dadR gene as a cis-acting regulatory region of the dad operon. Therefore, the dadR region may contain promoter and regulatory sequences of the dad operon. The DNA fragment of about 260 bp preceding dadA should correspond to dadR.
Evidence: [ICWHO]
[TIM]
Reference(s): [3] Huerta AM., et al., 2003
[1] Lobocka M., et al., 1994
[4] Mathew E., et al., 1996
[5] Zhi J., et al., 1999
[6] Zhi J., et al., 1998
TF binding sites (TFBSs)
[CRP,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP1 activator dadAp2 1237455 1237477 -59.5 agagtcagggAGATGTGAGCCAGCTCACCATAAaaaagccgca nd [APIORCISFBSCS], [BPP], [GEA] [6]
proximal CRP-cAMP activator dadAp2 1237520 1237541 7.0 agttatcaagATGTGATTAGATTATTATTCTTTtactgtatct nd [APIORCISFBSCS], [BPP], [GEA] nd
[Lrp,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote Lrp1 repressor dadAp2 1237252 1237266 -266.0 acgcgcacctCATTGTTGTCGGCGCTctctgtgtgg nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp2 repressor dadAp2 1237277 1237291 -241.0 tctctgtgtgGAGCACCTCATTTCAAgcatagaaca nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp3 repressor dadAp2 1237325 1237339 -193.0 cgcgtcgccgGAGAATTTTTTTCTTTgcgatttctt nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
remote Lrp4 repressor dadAp2 1237356 1237370 -162.0 ttcttattatCAGAGTGCCACTAATCcgcttctgaa nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp5 repressor dadAp2 1237382 1237396 -136.0 cgcttctgaaCGGAATTTTATGCTGGataaaaaggg nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
remote Lrp6 repressor dadAp2 1237412 1237426 -106.0 aaagggcgttCAGCAGGAGATACTAAagacgccata nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
proximal Lrp7 repressor dadAp2 1237450 1237464 -68.0 gccgcagagtCAGGGAGATGTGAGCCagctcaccat nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
proximal Lrp8 repressor dadAp2 1237495 1237509 -23.0 gcatgttgaaTAATATTTTCAACTGAgttatcaaga nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
proximal Lrp9 repressor dadAp2 1237527 1237541 10.0 aagatgtgatTAGATTATTATTCTTTtactgtatct nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
remote Lrp10 repressor dadAp2 1237574 1237588 57.0 agtggctatgCGAGTTGTCATACTGGgaagtggtgt nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp11 repressor dadAp2 1237596 1237610 79.0 ctgggaagtgGTGTGGTAGGCGTTGCcagcgcctgg nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
Note(s): 1

1Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
2Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
3Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
4Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
5Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
6Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
7Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
8Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
9Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
10Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
11Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,20191Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
2Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
3Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
4Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
5Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
6Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
7Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
8

9Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
11Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
12Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
13Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019


Transcription unit          
Name: dadAX
Gene(s): dadA, dadX   Genome Browser M3D Gene expression COLOMBOS
Note(s): dadAX operon expression is upregulated upon L-valine addition (isoleucine starvation) in the cellular growth medium 32211022.
A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for dadA . This structure could regulate the expression of the gene, as observed for hemL gene expression 31964733.
Evidence: [ITCR] Inferred through co-regulation
[PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Lobocka M., et al., 1994
[2] Wild J., et al., 1985
Promoter
Name: dadAp3
+1: 1237538
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 33
Sequence: aaaagccgcatgttgaataatattttcaactgagttatcaagatgtgattagattattatTcttttactgtatctaccgtt
                              -35                      -10  +1                   
Evidence: [ICWHO]
[TIM]
Reference(s): [3] Huerta AM., et al., 2003
[4] Mathew E., et al., 1996
[5] Zhi J., et al., 1999
[6] Zhi J., et al., 1998
TF binding sites (TFBSs)
[CRP,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator dadAp3 1237455 1237477 -72.5 agagtcagggAGATGTGAGCCAGCTCACCATAAaaaagccgca nd [APIORCISFBSCS], [BPP], [GEA] [6]
proximal CRP-cAMP2 activator dadAp3 1237518 1237539 -9.5 tgagttatcaAGATGTGATTAGATTATTATTCTtttactgtat nd [APIORCISFBSCS], [BPP], [GEA], [APIORCISFBSCS], [BPP], [GEA] [4], [5], [6]
[Lrp,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote Lrp1 repressor dadAp3 1237252 1237266 -279.0 acgcgcacctCATTGTTGTCGGCGCTctctgtgtgg nd [APIORCISFBSCS], [BPP], [GEA], [RSE], [SM], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp2 repressor dadAp3 1237277 1237291 -254.0 tctctgtgtgGAGCACCTCATTTCAAgcatagaaca nd [APIORCISFBSCS], [BPP], [GEA], [RSE], [SM], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp3 repressor dadAp3 1237325 1237339 -206.0 cgcgtcgccgGAGAATTTTTTTCTTTgcgatttctt nd [APIORCISFBSCS], [BPP], [EME], [GEA], [RSE], [SM], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
remote Lrp4 repressor dadAp3 1237356 1237370 -175.0 ttcttattatCAGAGTGCCACTAATCcgcttctgaa nd [APIORCISFBSCS], [BPP], [GEA], [RSE], [SM], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp5 repressor dadAp3 1237382 1237396 -149.0 cgcttctgaaCGGAATTTTATGCTGGataaaaaggg nd [APIORCISFBSCS], [BPP], [EME], [GEA], [RSE], [SM], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
remote Lrp6 repressor dadAp3 1237412 1237426 -119.0 aaagggcgttCAGCAGGAGATACTAAagacgccata nd [APIORCISFBSCS], [BPP], [GEA], [RSE], [SM], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
proximal Lrp7 repressor dadAp3 1237450 1237464 -81.0 gccgcagagtCAGGGAGATGTGAGCCagctcaccat nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
proximal Lrp8 repressor dadAp3 1237495 1237509 -36.0 gcatgttgaaTAATATTTTCAACTGAgttatcaaga nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
proximal Lrp9 repressor dadAp3 1237527 1237541 -4.0 aagatgtgatTAGATTATTATTCTTTtactgtatct nd [EME], [RSE], [AIBSPD], [APIORCISFBSCS], [BPP], [CCE], [CSE], [GEA], [SM] [4], [5], [7], [8]
remote Lrp10 repressor dadAp3 1237574 1237588 44.0 agtggctatgCGAGTTGTCATACTGGgaagtggtgt nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
remote Lrp11 repressor dadAp3 1237596 1237610 66.0 ctgggaagtgGTGTGGTAGGCGTTGCcagcgcctgg nd [RSE], [APIORCISFBSCS], [BPP], [CSE], [GEA], [SM] [4], [5], [7]
Note(s): 2This site probably plays little or no role in dadAX expression.1Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
2Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
3Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
4Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
5Changes in this site significantly altered dadAX expression
Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
6Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
7Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
8Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
9Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
10Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
11Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,20191Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
2Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
3Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
4Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
5Changes in this site significantly altered dadAX expression
Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
6Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
7Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
9Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
10This site probably plays little or no role in dadAX expression.
11Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
12Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019
13Additional evidence supports this TF-gene interaction with no precise position defined.
GCs_GeneExpression_EXP: lrp knockout mutant| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm. GCs_GeneExpression_CONTROL: wild-type| MOPS| 0.2% glycerol| | 37.0 C| | | OD600 from 0.15 to 0.25| exponential phase| | |200 rpm Kroner GM,2019


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [TIM] Transcription initiation mapping

 [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis

 [RSE] RNA-seq evidence

 [CSE] ChIP-seq evidence

 [SM] Site mutation

 [EME] Expression microarray evidence

 [AIBSPD] Automated inference based on sequence pattern discovery

 [CCE] ChIP-chip evidence


Reference(s)    

 [1] Lobocka M., Hennig J., Wild J., Klopotowski T., 1994, Organization and expression of the Escherichia coli K-12 dad operon encoding the smaller subunit of D-amino acid dehydrogenase and the catabolic alanine racemase., J Bacteriol 176(5):1500-10

 [2] Wild J., Hennig J., Lobocka M., Walczak W., Klopotowski T., 1985, Identification of the dadX gene coding for the predominant isozyme of alanine racemase in Escherichia coli K12., Mol Gen Genet 198(2):315-22

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [4] Mathew E., Zhi J., Freundlich M., 1996, Lrp is a direct repressor of the dad operon in Escherichia coli., J Bacteriol 178(24):7234-40

 [5] Zhi J., Mathew E., Freundlich M., 1999, Lrp binds to two regions in the dadAX promoter region of Escherichia coli to repress and activate transcription directly., Mol Microbiol 32(1):29-40

 [6] Zhi J., Mathew E., Freundlich M., 1998, In vitro and in vivo characterization of three major dadAX promoters in Escherichia coli that are regulated by cyclic AMP-CRP and Lrp., Mol Gen Genet 258(4):442-7

 [7] Kroner GM., Wolfe MB., Freddolino PL., 2019, Escherichia coli Lrp Regulates One-Third of the Genome via Direct, Cooperative, and Indirect Routes., J Bacteriol 201(3)

 [8] Cho BK., Barrett CL., Knight EM., Park YS., Palsson BO., 2008, Genome-scale reconstruction of the Lrp regulatory network in Escherichia coli., Proc Natl Acad Sci U S A 105(49):19462-7

RegulonDB