RegulonDB RegulonDB 10.9: Operon Form
   

feaR operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: feaR
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: feaR
Gene(s): feaR   Genome Browser M3D Gene expression COLOMBOS
Note(s): ArcA could be a negative regulator of feaR expression Zeng J,2013.
The expression of feaR is regulated by carbon or nitrogen limitation Zeng J,2013.
It is probable that the activities of both feaRp2 and feaRp1 are inhibited by binding of QseB to its downstream binding site Pasupuleti S,2018 If the affinity of QseB-P for the upstream site is higher than the affinity for the downstream site, feaR transcription would be maximally induced by intermediate levels of QseB-P and repressed by higher levels of QseB-P Pasupuleti S,2018
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Yamashita M., et al., 1996
Promoter
Name: feaRp2
+1: 1447309
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 26
Sequence: tatttcctatagtcaggctcattagcttcgtttattgcaacacaaatgcaacaataaaaaTacatttcacagagcgaaaac
                                   -35            -10       +1                   
Evidence: [IHBCE]
[TIM]
Reference(s): [2] Zeng J., et al., 2013
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote CRP-cAMP activator feaRp2 1447410 1447431 -111.5 ttcgctttgtCAGCTGTGACAAGCTCCGCAAATcgtgacaata nd [APIORCISFBSCS] [1]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal Nac activator feaRp2 1447334 1447348 -32.5 agtcaggctcATTAGCTTCGTTTATTgcaacacaaa nd [IHBCE] [2]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal NsrR repressor feaRp2 1447303 1447314 2.0 atgcaacaatAAAAATACATTTcacagagcga nd [APIORCISFBSCS], [GEA] [5]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal PhoB-Phosphorylated repressor feaRp2 1447317 1447335 -17.0 agcttcgtttATTGCAACACAAATGCAACAataaaaatac nd [APIORCISFBSCS], [BPP], [GEA] [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal QseB-Phosphorylated1 repressor feaRp2 1447306 1447318 -3.0 cacaaatgcaACAATAAAAATACAtttcacagag nd [AIBSCS], [GEA] [4]
Note(s): 1QseB regulates feaR expression, as identified using Escherichia coli RP437 (CV1) Pasupuleti S,20184QseB regulates feaR expression, as identified using Escherichia coli RP437 (CV1) Pasupuleti S,2018


Transcription unit          
Name: feaR
Gene(s): feaR   Genome Browser M3D Gene expression COLOMBOS
Note(s): The position of the putative GlrR-binding sites suggests that the feaRp1 promoter is the most likely candidate for induction of feaRp1 transcription; this promoter also has the closest match to the σ70 -35 and -10 consensus sequences Pasupuleti S,2018
Based on sequence analysis, it is possible that GlrR regulates feaR expression together with QseB, since the GACA bases that overlap the -10 region of the feaRp3 promoter and the ACA bases that overlap the -35 region of the feaRp2 promoter are the last four and three bases, respectively, of the reported GlrR (QseF) consensus binding site Pasupuleti S,2018
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Yamashita M., et al., 1996
Promoter
Name: feaRp1
+1: 1447349
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 66
Sequence: cgtgacaataaccgcttatgtctctatgcctgacaagacttatttcctatagtcaggctcAttagcttcgtttattgcaac
                              -35               -10         +1                   
Evidence: [IHBCE]
[TIM]
Reference(s): [2] Zeng J., et al., 2013
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal QseB-Phosphorylated1 activator feaRp1 1447392 1447404 -49.0 gcaaatcgtgACAATAACCGCTTAtgtctctatg nd [AIBSCS], [GEA] [4]
Note(s): 1QseB regulates feaR expression, as identified using Escherichia coli RP437 (CV1) Pasupuleti S,20181QseB regulates feaR expression, as identified using Escherichia coli RP437 (CV1) Pasupuleti S,2018


Transcription unit       
Name: feaR
Synonym(s): maoB
Gene(s): feaR   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Yamashita M., et al., 1996
Promoter
Name: feaRp
+1: 1447367
Distance from start of the gene: 84
Sequence: gtgacaagctccgcaaatcgtgacaataaccgcttatgtctctatgcctgacaagacttaTttcctatagtcaggctcatt
Evidence: [HIPP]
Reference(s): [6] Ferrandez A., et al., 1997


Transcription unit       
Name: feaR
Gene(s): feaR   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Yamashita M., et al., 1996
Promoter
Name: feaRp3
+1: 1447394
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 111
Sequence: ttcgctgtgacattcgctttgtcagctgtgacaagctccgcaaatcgtgacaataaccgcTtatgtctctatgcctgacaa
                            -35                  -10        +1                   
Evidence: [IHBCE]
[TIM]
Reference(s): [2] Zeng J., et al., 2013





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