RegulonDB RegulonDB 10.10: Operon Form
   

clpA operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: clpA
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: clpA
Gene(s): clpA   Genome Browser M3D Gene expression COLOMBOS
Note(s): Downstream from the termination of translation, this operon has a stable 14-bp stem and 4-bp loop, consistent with a transcription termination signal Gottesman S,1990.
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Gottesman S., et al., 1990
Promoter
Name: clpAp1
+1: 923080
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 184
Sequence: ttacactccgatggagtttgttattgacgtgttacaaaaattcttttcttatgatgtagaAcgtgcaacgcaattgatgct
                        -35                       -10       +1                   
Evidence: [HIPP]
[ICWHO]
[IHBCE]
[TIM]
Reference(s): [1] Gottesman S., et al., 1990
[2] Huerta AM., et al., 2003


Transcription unit       
Name: clpA
Gene(s): clpA   Genome Browser M3D Gene expression COLOMBOS
Note(s): Downstream from the termination of translation, this operon has a stable 14-bp stem and 4-bp loop, consistent with a transcription termination signal Gottesman S,1990.
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Gottesman S., et al., 1990
Promoter
Name: clpAp2
+1: 923092
Distance from start of the gene: 172
Sequence: ggagtttgttattgacgtgttacaaaaattcttttcttatgatgtagaacgtgcaacgcaAttgatgctcgctgttcacta
Evidence: [TIM]
Reference(s): [1] Gottesman S., et al., 1990


Transcription unit       
Name: clpA
Gene(s): clpA   Genome Browser M3D Gene expression COLOMBOS
Note(s): Downstream from the termination of translation, this operon has a stable 14-bp stem and 4-bp loop, consistent with a transcription termination signal Gottesman S,1990.
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Gottesman S., et al., 1990
Promoter
Name: clpAp3
+1: 923210
Distance from start of the gene: 54
Sequence: gttgcagaaaccaaagtggcgatggtgaacaagtacgcgagggagaatgagcatccattgCtgtgtacgctagaaaaagcc
Evidence: [TIM]
Reference(s): [1] Gottesman S., et al., 1990


Evidence    

 [HIPP] Human inference of promoter position

 [ICWHO] Inferred computationally without human oversight

 [IHBCE] Inferred by a human based on computational evidence

 [TIM] Transcription initiation mapping


Reference(s)    

 [1] Gottesman S., Clark WP., Maurizi MR., 1990, The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate., J Biol Chem 265(14):7886-93

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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