RegulonDB RegulonDB 11.1: Operon Form

trpR operon and associated TUs in Escherichia coli K-12 genome

Name: trpR
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Name: trpR
Gene(s): trpR   Genome Browser M3D Gene expression COLOMBOS
Note(s): The expression of the trpR gene is repressed threefold by the TrpR protein. This protein binds around the transcriptional start site of trpR. Therefore, TrpR could minimally block the transcription initiation because the RNA polymerase could not bind to the promoterKlig LS,1988
The trpLEDCBA, aroH, and trpR operons are coordinately regulated by the TrpR transcriptional repressor in response to intracellular levels of L-tryptophan (Kumamoto AA,1987and references therein). TrpR acts differently at each operator and binds to multiple helically stacked sites Kumamoto AA,1987
Evidence: [EXP-IDA-BOUNDARIES-DEFINED] Boundaries of transcription experimentally identified
Reference(s): [1] Gunsalus RP., et al., 1980
Name: trpRp
+1: 4632704
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 56
Sequence: gccacggaatggggacgtcgttactgatccgcacgtttatgatatgctatcgtactctttAgcgagtacaaccgggggagg
                     -35                        -10         +1                   
Note(s): trpRp is regulated over a four- to fivefold range by TrpR Kumamoto AA,1987and references therein|.
Evidence: [COMP-AINF]
Reference(s): [1] Gunsalus RP., et al., 1980
[2] Huerta AM., et al., 2003
Type: rho-independent
Reference(s): [1] Gunsalus RP., et al., 1980
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal TrpR-L-tryptophan repressor trpRp 4632695 4632712 -0.5 atatgctatcGTACTCTTTAGCGAGTACaaccggggga nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] W [1], [3], [4], [5], [6], [7]