|Gene(s):||bioB, bioF, bioC, bioD Genome Browser M3D Gene expression COLOMBOS|
|Note(s):||The expression of bioBFCD is repressed by the BirA protein, which is not only a transcriptional factor but also a biotin protein ligase (whose target is the AccB protein). Therefore, when AccB is overproduced, the bio operon is derepressed, because BirA is linked to AccB. On the other hand, as AccC protein (which forms a complex with AccB) is overproduced, AccB is kidnapped from the BirA-AccB complex (so that now AccB binds to AccC) and BirA is allowed to freely bind to its operator site to repress the bio operon Abdel-Hamid AM, Cronan JE,2007.
The mRNA that contains the bioF gene has been observed mainly in the cellular membrane Kannaiah S, Livny J, Amster-Choder O,2019.
|Reference(s):|| Nath SK., et al., 1982|
|Sigma Factor:||Sigma70 Sigmulon|
|Distance from start of the gene:||42|
-35 -10 +1
 Huerta AM., et al., 2003
 Otsuka A., et al., 1978
|Type||Transcription factor||Function||Promoter||Binding Sites||Growth Conditions||Evidence||Confidence level (C: Confirmed, S: Strong, W: Weak)||Reference(s)|
|Transcription factor||Function||Promoter||Binding Sites||Evidence (Confirmed, Strong, Weak)||Reference(s)|
 Nath SK., Guha A., 1982, Abortive termination of bioBFCD RNA synthesized in vitro from the bioABFCD operon of Escherichia coli K-12., Proc Natl Acad Sci U S A 79(6):1786-90
 Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
 Otsuka A., Abelson J., 1978, The regulatory region of the biotin operon in Escherichia coli., Nature 276(5689):689-94