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| Operon |  |
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| Name: | fecABCDE |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | fecABCDE | |||||||||
| Synonym(s): | OP00206, fecIRABCDE | |||||||||
| Gene(s): | fecE, fecD, fecC, fecB, fecA Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | A possible role in the rpsA-ihfB, adhP, fecIR, and fecABCDE operons was described for functional abortive RNAs (faRNAs), based on computational prediction and described by Nair et al. 2017 28347827 Expression of fecA, along with that of other genes also regulated by Fur, is reduced under Zn excess Xu Z,2019. Downregulation of the fecABCDE operon was observed in a fecR R79/80K mutant 32015149 The arginine-to-lysine mutation prevents periplasmic translocation of the C-terminal domain of FecR, avoiding its binding to citrate-loaded FecA, and decouples the FecIR signal cascade 32015149 fecABCDE expression could be affected by OmpR, because the fecA gene was affected in an EnvZ mutant, part of the sensor pair of EnvZ/OmpR Gerken H,2020. |
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| Evidence: | [CV(LTED/PM)] cross validation(LTED/PM) [IEP] Inferred from expression pattern [ITCR] Inferred through co-regulation [LTED] Length of transcript experimentally determined [PM] Polar mutation |
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| Reference(s): | [1] Braun V. 1997 | |||||||||
| Promoter | ||||||||||
| Name: | fecAp | |||||||||
| +1: | 4516727 | |||||||||
| Distance from start of the gene: | 50 | |||||||||
| Sequence: |
tggataaacatttcaccactgtaaggaaaataattcttatttcgattgtcctttttacccTtctcgttcgactcatagctg |
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| Evidence: |
[CV(RPF/TIM)] [HIPP] [RPF] [TIM] |
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| Reference(s): |
[2] Enz S., et al., 1995 [3] Enz S., et al., 2003 [4] Silva AA., et al., 1998 |
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| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | Fur-Fe2+ | repressor | fecAp | 4516743 | 4516757 | -23.0 | tgtaaggaaaATAATTCTTATTTCGAttgtcctttt | nd | [APIORCISFBSCS], [BPP], [GEA] | [5], [6], [7] |
| proximal | Fur-Fe2+ | repressor | fecAp | 4516746 | 4516760 | -26.0 | cactgtaaggAAAATAATTCTTATTTcgattgtcct | nd | [AIBSCS], [APIORCISFBSCS], [BPP], [GEA] | [6], [7], [8], [9] |
| proximal | Fur-Fe2+ | repressor | fecAp | 4516749 | 4516763 | -29.0 | caccactgtaAGGAAAATAATTCTTAtttcgattgt | nd | [AIBSCS], [BPP], [GEA] | [5], [6], [7] |
| Note(s): | 1Based on microarray and RT-qPCR analyses, it was determined that the fecA and frdB genes are downregulated upon exposure to glutathione (GSH) Goswami M,20187Based on microarray and RT-qPCR analyses, it was determined that the fecA and frdB genes are downregulated upon exposure to glutathione (GSH) Goswami M,2018 |
| Reference(s) |
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[CV(RPF/TIM)] cross validation(RPF/TIM)