RegulonDB RegulonDB 10.9: Operon Form
   

mpl operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: mpl
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: mpl
Gene(s): mpl   Genome Browser M3D Gene expression COLOMBOS
Note(s): A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for mpl . This structure could regulate the expression of the gene, as observed for hemL gene expression 31964733.
Reference(s): [1] Talukder AA., et al., 1996
Promoter
Name: mplp
+1: 4455728
Sigma Factor: Sigma38 Sigmulon
Distance from start of the gene: 57
Sequence: ctcaatgttgcgctcaggtgaatcgcgccagcaaattacggattatcctgaaatgcgtttCtcacttgcccgacatatgcg
                       -35             -10                  +1                   
Note(s): We assigned a putative transcription start site to this promoter based on the observation that the majority of the promoters, whose transcription start sites were determined experimentally, present a distance of 6 nucleotides between the transcription start site and the -10 box.
Evidence: [HIPP]
[ICWHO]
Reference(s): [2] Huerta AM., et al., 2003
[1] Talukder AA., et al., 1996
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator mplp 4455680 4455701 -37.5 caatgttgcgCTCAGGTGAATCGCGCCAGCAAAttacggatta nd [AIBSCS] nd
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal Cra repressor mplp 4455683 4455700 -36.5 tgttgcgctcAGGTGAATCGCGCCAGCAAattacggatt nd [AIBSCS], [GEA] [3]


Transcription unit          
Name: mpl
Gene(s): mpl   Genome Browser M3D Gene expression COLOMBOS
Note(s): A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for mpl . This structure could regulate the expression of the gene, as observed for hemL gene expression 31964733.
Reference(s): [1] Talukder AA., et al., 1996
Promoter
Name: mplp1
+1: 4455728
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 57
Sequence: ctcaatgttgcgctcaggtgaatcgcgccagcaaattacggattatcctgaaatgcgtttCtcacttgcccgacatatgcg
                  -35                       -10             +1                   
Note(s): We assigned a putative transcription start site to this promoter based on the observation that the majority of the promoters, whose transcription start sites were determined experimentally, present a distance of 6 nucleotides between the transcription start site and the -10 box.
Evidence: [HIPP]
[ICWHO]
Reference(s): [2] Huerta AM., et al., 2003
[1] Talukder AA., et al., 1996
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator mplp1 4455680 4455701 -37.5 caatgttgcgCTCAGGTGAATCGCGCCAGCAAAttacggatta nd [AIBSCS] nd
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal Cra repressor mplp1 4455683 4455700 -36.5 tgttgcgctcAGGTGAATCGCGCCAGCAAattacggatt nd [AIBSCS], [GEA] [3]


Transcription unit       
Name: mpl
Gene(s): mpl   Genome Browser M3D Gene expression COLOMBOS
Note(s): A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for mpl . This structure could regulate the expression of the gene, as observed for hemL gene expression 31964733.
Reference(s): [1] Talukder AA., et al., 1996
Promoter
Name: mplp2
+1: 4455760
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 25
Sequence: aaattacggattatcctgaaatgcgtttctcacttgcccgacatatgcgtaaaatgagcgGcagattaaaaaaggatagtg
                           -35                    -10       +1                   
Note(s): We assigned a putative transcription start site to this promoter based on the observation that the majority of the promoters, whose transcription start site was determined experimentally, present a distance of 6 nucleotides between the transcription start site and the -10 box.
Evidence: [HIPP]
[ICWHO]
[RS-EPT-CBR]
Reference(s): [2] Huerta AM., et al., 2003
[4] Salgado H, et al., 2012
[1] Talukder AA., et al., 1996





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