RegulonDB RegulonDB 11.0: Operon Form

argCBH operon and associated TUs in Escherichia coli K-12 genome

Name: argCBH
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Name: argCBH
Synonym(s): OP00005
Gene(s): argC, argB, argH   Genome Browser M3D Gene expression COLOMBOS
Note(s): argCBH is also controlled by RpoS during the entry into the stationary phase. However, Weerasinghe JP, Dong T, Schertzberg MR, Kirchhof MG, Sun Y, Schellhorn HE,2006 could not determined if the rpoS effect was direct or indirect.
argCBH operon expression is downregulated upon L-valine addition (isoleucine starvation) in the cellular growth medium Gummesson B, Shah SA, Borum AS, Fessler M, Mitarai N, Sørensen MA, Svenningsen SL,2020.
Based on DNA microarray analysis, the mechanism of bacterial inactivation by carvacrol and citral was studied Chueca B, Pérez-Sáez E, Pagán R, García-Gonzalo D,2017. Treatment by both compounds caused membrane damage and activated metabolism through the production of nucleotides required for DNA and RNA synthesis and metabolic processes Chueca B, Pérez-Sáez E, Pagán R, García-Gonzalo D,2017. A total of 76 and 156 genes demonstrated significant transcriptional differences by carvacrol and citral, respectively. Genes upregulated by carvacrol treatment included the multidrug efflux pump genes acrA and mdtM, genes related to the phage shock response, pspA, pspB, pspC, pspD, pspF, and pspG, and genes whose products are important for biosynthesis of arginine (argC, argG, artJ) and purine nucleotides (purC, purM). Genes upregulated by citral treatment included purH, pyrB, and pyrI. On the other hand, mutations in several differentially expressed genes confirmed the roles of ygaV, yjbO, pspC, sdhA, yejG, and ygaV in mechanisms of inactivation by carvacrol and citral Chueca B, Pérez-Sáez E, Pagán R, García-Gonzalo D,2017.
Reference(s): [1] Natter W., et al., 1977
[2] Sens D., et al., 1977
Name: argCp
+1: 4154885
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 116
Sequence: aatggcggtaatttgtttttcattgttgacacacctctggtcatgatagtatcaatattcAtgcagtatttatgaataaaa
                          -35                  -10          +1                   
Evidence: [ICWHO]
Reference(s): [3] Huerta AM., et al., 2003
[4] Piette J., et al., 1982
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal ArgR-L-arginine repressor argCp 4154873 4154890 -3.5 ggtcatgataGTATCAATATTCATGCAGtatttatgaa nd [GEA], [AIBSCS], [BCE], [BPP], [SM] [5], [6]
proximal ArgR-L-arginine repressor argCp 4154895 4154912 19.5 atgcagtattTATGAATAAAAATACACTaacgttgagc nd [EME], [GEA], [AIBSCS], [AIBSPD], [BCE], [BPP], [CEE], [SM] [5], [6]

Transcription unit       
Name: argH
Gene(s): argH   Genome Browser M3D Gene expression COLOMBOS
Evidence: [NBDA] No biological data available