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| Operon |  |
|---|---|
| Name: | acrR |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | acrR | |||||||||
| Gene(s): | acrR Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | In an experiment using increasing concentrations of tetracycline, the transcription of the acrR gene is induced in low concentrations (1.5 and 4 mg/L), but this induction decreases in high concentrations (10 mg/L) 17426813 | |||||||||
| Promoter | ||||||||||
| Name: | acrRp | |||||||||
| +1: | 485699 | |||||||||
| Sigma Factor: | Sigma70 Sigmulon | |||||||||
| Distance from start of the gene: | 62 | |||||||||
| Sequence: |
gatttcaaattggtcaatggtcaaaagttaataaacccattgctgcgtttatattatcgtCgtgctatggtacatacattc -35 -10 +1 |
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| Evidence: |
[AIPP] [ICWHO] |
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| Reference(s): | [1] Huerta AM., et al., 2003 | |||||||||
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | AcrR1 | repressor | acrRp | 485709 | 485732 | 22.5 | cgtgctatggTACATACATTCACAAATGTATGTAAatctaacgcc | nd | [AIBSCS], [APIORCISFBSCS], [BCE], [BPP], [GEA], [AIBSCS], [BPP], [GEA] | [2], [3], [4] |
| Note(s): | 1The acrR gene, which is located upstream of and in the opposite direction of acrAB, encodes AcrR, a negative DNA-binding transcriptional regulator for a multidrug efflux pump. The presence of acrR upstream of the acrAB operon in E. coli suggests that the operon may be controlled at the level of transcription by this regulator Ma D,19961The acrR gene, which is located upstream of and in the opposite direction of acrAB, encodes AcrR, a negative DNA-binding transcriptional regulator for a multidrug efflux pump. The presence of acrR upstream of the acrAB operon in E. coli suggests that the operon may be controlled at the level of transcription by this regulator Ma D,1996 |
| RNA cis-regulatory element | |
|---|
| Regulation, transcriptional elongation | |
| Attenuator type: | Transcriptional |
| Strand: | forward |
| Evidence: | [ICA] Inferred by computational analysis |
| Reference(s): | [5] Merino E, et al., 2005 |
| Structure type | Energy | LeftPos | RightPos | Sequence (RNA-strand) | |
|---|---|---|---|---|---|
| terminator | -6.8 | 485590 | 485616 | aacgaccgccAGAGGCGTAAACCCTCTGTTTTTGTTcatatgtaaa | |
| anti-terminator | -3.8 | 485582 | 485598 | agcatcagaaCGACCGCCAGAGGCGTaaaccctctg | |
| anti-anti-terminator | -12.8 | 485539 | 485586 | ggcctgtttgTCGTCACATCCTGTTAGGGCTAAGCTGCCTGAGAGCATCAGAACGACcgccagaggc |
| Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos" |
| Reference(s) |
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|---|---|
[AIPP] Automated inference of promoter position