RegulonDB RegulonDB 10.9: Operon Form
   

acrR operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: acrR
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: acrR
Gene(s): acrR   Genome Browser M3D Gene expression COLOMBOS
Note(s): In an experiment using increasing concentrations of tetracycline, the transcription of the acrR gene is induced in low concentrations (1.5 and 4 mg/L), but this induction decreases in high concentrations (10 mg/L) 17426813
Promoter
Name: acrRp
+1: 485699
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 62
Sequence: gatttcaaattggtcaatggtcaaaagttaataaacccattgctgcgtttatattatcgtCgtgctatggtacatacattc
                            -35                     -10     +1                   
Evidence: [AIPP]
[ICWHO]
Reference(s): [1] Huerta AM., et al., 2003
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal AcrR1 repressor acrRp 485709 485732 22.5 cgtgctatggTACATACATTCACAAATGTATGTAAatctaacgcc nd [AIBSCS], [APIORCISFBSCS], [BCE], [BPP], [GEA], [AIBSCS], [BPP], [GEA] [2], [3], [4]
Note(s): 1The acrR gene, which is located upstream of and in the opposite direction of acrAB, encodes AcrR, a negative DNA-binding transcriptional regulator for a multidrug efflux pump. The presence of acrR upstream of the acrAB operon in E. coli suggests that the operon may be controlled at the level of transcription by this regulator Ma D,19961The acrR gene, which is located upstream of and in the opposite direction of acrAB, encodes AcrR, a negative DNA-binding transcriptional regulator for a multidrug efflux pump. The presence of acrR upstream of the acrAB operon in E. coli suggests that the operon may be controlled at the level of transcription by this regulator Ma D,1996


RNA cis-regulatory element    
Regulation, transcriptional elongation  
Attenuator type: Transcriptional
Strand: forward
Evidence: [ICA] Inferred by computational analysis
Reference(s): [5] Merino E, et al., 2005
  Structure type Energy LeftPos RightPos Sequence (RNA-strand)
  terminator -6.8 485590 485616 aacgaccgccAGAGGCGTAAACCCTCTGTTTTTGTTcatatgtaaa
  anti-terminator -3.8 485582 485598 agcatcagaaCGACCGCCAGAGGCGTaaaccctctg
  anti-anti-terminator -12.8 485539 485586 ggcctgtttgTCGTCACATCCTGTTAGGGCTAAGCTGCCTGAGAGCATCAGAACGACcgccagaggc
Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos"





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