RegulonDB RegulonDB 10.9: Operon Form

dsrA operon and associated TUs in Escherichia coli K-12 genome

Name: dsrA
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Name: dsrA
Gene(s): dsrA   Genome Browser M3D Gene expression COLOMBOS
Evidence: [AISGDTU] Automated inference that a single-gene directon is a transcription unit
Name: dsrAp
+1: 2025313
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 0
Sequence: ttaatcattcatatggcgaatattttcttgtcagcgaaaaaaattgcggataaggtgatgAacacatcagatttcctggtg
                            -35                    -10      +1                   
Evidence: [HIPP]
Reference(s): [1] Huerta AM., et al., 2003
[2] Sledjeski D., et al., 1995
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd LeuO repressor dsrAp nd nd nd nd nd [BPP], [GEA], [IGI] [3]
Allosteric regulation of RNA-polymerase
  Regulator Function Promoter target of RNApol Growth Conditions Note Evidence Reference
  DksA-ppGpp activation dsrAp nd DksA and ppGpp activate the dsrA promoter, improving rpoS translation Girard ME,2018 On the other hand, DksA-ppGpp can increase dsrA expression indirectly by another mechanism, possibly by reducing rRNA transcription and thereby increasing RNAP availability Girard ME,2018 [APPH]
Evidence: [APPH] Assay of protein purified to homogeneity
[GEA] Gene expression analysis
Reference(s): [4] Girard ME., et al., 2018