RegulonDB RegulonDB 11.1: Operon Form
   

uidABC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: uidABC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: uidABC
Gene(s): uidC, uidB, uidA   Genome Browser M3D Gene expression COLOMBOS
Reference(s): [1] Blanco C., et al., 1982
[2] Blattner FR., et al., 1997
Promoter
Name: uidAp
+1: 1696152
Distance from start of the gene: 81
Sequence: gttttttgatcgcggtgtcagttctttttatttccatttctcttccatgggtttctcacaGataactgtgtgcaacacaga
Evidence: [EXP-IDA-TRANSCRIPTION-INIT-MAPPING]
Reference(s): [3] Blanco C. 1987
TF binding sites (TFBSs)
[CRP,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cyclic-AMP activator uidAp 1696231 1696253 -89.5 gttttaaagaTTAATGCGATCTATATCACGCTGtgggtattgc nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS] W [4], [6]
[UidR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote UidR repressor uidAp 1696298 1696313 -153.5 tcgttcccaaTACGCTCGAACGAACGttcggttgct nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [4], [5]
[UxuR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal UxuR repressor uidAp 1696116 1696133 28.5 gtgcaacacaGAATTGGTTAACTAATCAgattaaaggt nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-HINF-SIMILAR-TO-CONSENSUS] W [4], [5]


Evidence    

 [EXP-IDA-TRANSCRIPTION-INIT-MAPPING] Transcription initiation mapping

 [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis

 [COMP-AINF-SIMILAR-TO-CONSENSUS] Automated inference based on similarity to consensus sequences

 [COMP-HINF-SIMILAR-TO-CONSENSUS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.


Reference(s)    

 [1] Blanco C., Ritzenthaler P., Mata-Gilsinger M., 1982, Cloning and endonuclease restriction analysis of uidA and uidR genes in Escherichia coli K-12: determination of transcription direction for the uidA gene., J Bacteriol 149(2):587-94

 [2] Blattner FR., Plunkett G., Bloch CA., Perna NT., Burland V., Riley M., Collado-Vides J., Glasner JD., Rode CK., Mayhew GF., Gregor J., Davis NW., Kirkpatrick HA., Goeden MA., Rose DJ., Mau B., Shao Y., 1997, The complete genome sequence of Escherichia coli K-12., Science 277(5331):1453-74

 [3] Blanco C., 1987, Transcriptional and translational signals of the uidA gene in Escherichia coli K12., Mol Gen Genet 208(3):490-8

 [4] Blanco C., Mata-Gilsinger M., Ritzenthaler P., 1985, The use of gene fusions to study the expression of uidR, a negative regulatory gene of Escherichia coli K-12., Gene 36(1-2):159-67

 [5] Blanco C., Ritzenthaler P., Mata-Gilsinger M., 1986, Negative dominant mutations of the uidR gene in Escherichia coli: genetic proof for a cooperative regulation of uidA expression., Genetics 112(2):173-82

 [6] Tsai MJ., Wang JR., Yang CD., Kao KC., Huang WL., Huang HY., Tseng CP., Huang HD., Ho SY., 2018, PredCRP: predicting and analysing the regulatory roles of CRP from its binding sites in Escherichia coli., Sci Rep 8(1):951

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