RegulonDB RegulonDB 10.9: Operon Form
   

murQP-yfeW operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: murQP-yfeW
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: murQP
Gene(s): murQ, murP   Genome Browser M3D Gene expression COLOMBOS
Note(s): murR and murQ are divergently orientated and expressed from nonoverlapping face-to-face (convergent) promoters, and their transcripts are complementary at the 5' end. CRP controls positively murQP expression and it also may affect murR transcription as a consequence of this unusual promoter arrangement (face-to-face) Jaeger T,2008
Evidence: [PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Jaeger T., et al., 2008
Promoter
Name: murQp
+1: 2545733
Sigma Factor: Sigma38 Sigmulon
Distance from start of the gene: 40
Sequence: tgcgagtgtagactcaatgattcctttaagcctgtcaattcgggatatatgattccatacAtctgcaattatttgatcgta
                          -35                 -10           +1                   
Evidence: [ICWHO]
[RS-EPT-CBR]
[TIM]
Reference(s): [2] Huerta AM., et al., 2003
[1] Jaeger T., et al., 2008
[3] Salgado H, et al., 2012
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator murQp 2545651 2545672 -71.5 ccgcttaagtTCTTATGACGCTCTTCACACTCTgcgagtgtag nd [AIBSCS], [BPP], [GEA] [1]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MurR repressor murQp 2545682 2545697 -44.0 ctgcgagtgtAGACTCAATGATTCCTttaagcctgt nd [BPP], [GEA], [ICWHO] [1]
proximal MurR repressor murQp 2545714 2545729 -12.0 ctgtcaattcGGGATATATGATTCCAtacatctgca nd [BPP], [GEA], [ICWHO] [1]


Transcription unit          
Name: murQP
Gene(s): murQ, murP   Genome Browser M3D Gene expression COLOMBOS
Note(s): murR and murQ are divergently orientated and expressed from nonoverlapping face-to-face (convergent) promoters, and their transcripts are complementary at the 5' end. CRP controls positively murQP expression and it also may affect murR transcription as a consequence of this unusual promoter arrangement (face-to-face) Jaeger T,2008
Evidence: [PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Jaeger T., et al., 2008
Promoter
Name: murQp1
+1: 2545733
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 40
Sequence: tgcgagtgtagactcaatgattcctttaagcctgtcaattcgggatatatgattccatacAtctgcaattatttgatcgta
                         -35                    -10         +1                   
Evidence: [ICWHO]
[RS-EPT-CBR]
[TIM]
Reference(s): [2] Huerta AM., et al., 2003
[1] Jaeger T., et al., 2008
[3] Salgado H, et al., 2012
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator murQp1 2545651 2545672 -71.5 ccgcttaagtTCTTATGACGCTCTTCACACTCTgcgagtgtag nd [AIBSCS], [BPP], [GEA] [1]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MurR repressor murQp1 2545682 2545697 -44.0 ctgcgagtgtAGACTCAATGATTCCTttaagcctgt nd [BPP], [GEA], [ICWHO] [1]
proximal MurR repressor murQp1 2545714 2545729 -12.0 ctgtcaattcGGGATATATGATTCCAtacatctgca nd [BPP], [GEA], [ICWHO] [1]


Transcription unit          
Name: murQP
Gene(s): murQ, murP   Genome Browser M3D Gene expression COLOMBOS
Note(s): murR and murQ are divergently orientated and expressed from nonoverlapping face-to-face (convergent) promoters, and their transcripts are complementary at the 5' end. CRP controls positively murQP expression and it also may affect murR transcription as a consequence of this unusual promoter arrangement (face-to-face) Jaeger T,2008
Evidence: [PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Jaeger T., et al., 2008
Promoter
Name: murQp2
+1: 2545741
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 32
Sequence: tagactcaatgattcctttaagcctgtcaattcgggatatatgattccatacatctgcaaTtatttgatcgtaaatagtaa
                        -35                     -10         +1                   
Evidence: [ICWHO]
[TIM]
Reference(s): [2] Huerta AM., et al., 2003
[1] Jaeger T., et al., 2008
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP activator murQp2 2545651 2545672 -79.5 ccgcttaagtTCTTATGACGCTCTTCACACTCTgcgagtgtag nd [AIBSCS], [BPP], [GEA], [AIBSCS], [BPP], [GEA] [1]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MurR repressor murQp2 2545682 2545697 -52.0 ctgcgagtgtAGACTCAATGATTCCTttaagcctgt nd [BPP], [GEA], [ICWHO], [BPP], [GEA], [ICWHO] [1]
proximal MurR repressor murQp2 2545714 2545729 -20.0 ctgtcaattcGGGATATATGATTCCAtacatctgca nd [BPP], [GEA], [BPP], [GEA], [ICWHO] [1]


Transcription unit       
Name: murQP-yfeW
Gene(s): murQ, murP, yfeW   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight
[ITCR] Inferred through co-regulation
Reference(s): [4] Maciag A., et al., 2011





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