|Gene(s):||ogt Genome Browser M3D Gene expression COLOMBOS|
|Note(s):||Derrick et al. (2009) suggested that induction of ogt by NarL alone in response to external nitrate provides a prophylactic effect against possible genotoxicity arising from nitrate metabolism Squire DJ,2009 NarL activates the ogt promoter independently of FNR Squire DJ,2009 NarL (E273 residue) appears to interact directly with RNA polymerase (α-CTD) to activate transcription of the ogt promoter Ruanto P,2020.
The ogt promoter is induced by NarL in response to nitrate ions, without help from FNR Squire DJ,2009
Based on experiments utilizing a mutant background, it was shown that NarP plays little or no role in the ogt promoter region Squire DJ,2009
|Distance from start of the gene:||48|
 Potter PM., et al., 1987
 Ruanto P., et al., 2020
|Gene(s):||ogt, abgT, abgB, abgA Genome Browser M3D Gene expression COLOMBOS|
|Note(s):||Although a putative σ54-binding site was identified upstream of the abgB gene and the gene expression was affected in microarray experiments in a mutant
σ54 strain and a σ54-overexpressing strain, ChIP assays demonstrated that σ54 does not bind upstream of abgB Zhao K,2010 Therefore, we did not assign a σ54 promoter to this gene.
|Evidence:||[ICWHO] Inferred computationally without human oversight|
 Potter PM., Wilkinson MC., Fitton J., Carr FJ., Brennand J., Cooper DP., Margison GP., 1987, Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli., Nucleic Acids Res 15(22):9177-93
 Squire DJ., Xu M., Cole JA., Busby SJ., Browning DF., 2009, Competition between NarL-dependent activation and Fis-dependent repression controls expression from the Escherichia coli yeaR and ogt promoters., Biochem J 420(2):249-57