RegulonDB RegulonDB 10.8: Operon Form
   

nfsB operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: nfsB
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: nfsB
Synonym(s): nfnB
Gene(s): nfsB   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: nfsBp
+1: 605453
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 29
Sequence: gaaatctatagcgcatttttctcgcttaccatttctcgttgaaccttgtaatctgctggcAcgcaaaattactttcacatg
                          -35                    -10        +1                   
Evidence: [HIPP]
[RS-EPT-CBR]
Reference(s): [1] Barbosa TM., et al., 2002
[2] Salgado H, et al., 2012
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MarA1 activator nfsBp 605487 605507 -43.5 agcggaaatcTATAGCGCATTTTTCTCGCTTaccatttctc nd [APIORCISFBSCS], [BPP], [CV(CHIP-SV/GEA/ROMA)], [CV(GEA/ROMA)], [GEA] [1], [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal Rob activator nfsBp 605487 605507 -43.5 agcggaaatcTATAGCGCATTTTTCTCGCTTaccatttctc nd [APIORCISFBSCS], [CV(GEA/ROMA)], [GEA] [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal SoxS activator nfsBp 605487 605507 -43.5 agcggaaatcTATAGCGCATTTTTCTCGCTTaccatttctc nd [APIORCISFBSCS], [BPP], [CV(CHIP-SV/GEA/ROMA)], [CV(GEA/ROMA)], [GEA] [3], [4]
Note(s): 1There are four putative sites to bind MarA, but just one at position -43.5 is necessary to activate the transcription of nfnB. In vitro, but not in vivo, the proteins Rob and SoxS activate the transcription of nfnB and they bind to the MarA-binding site when they are present in a high concentration.3There are four putative sites to bind MarA, but just one at position -43.5 is necessary to activate the transcription of nfnB. In vitro, but not in vivo, the proteins Rob and SoxS activate the transcription of nfnB and they bind to the MarA-binding site when they are present in a high concentration.





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