RegulonDB RegulonDB 10.10: Operon Form
   

hemA-prfA-prmC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: hemA-prfA-prmC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: hemA
Gene(s): hemA   Genome Browser M3D Gene expression COLOMBOS
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Verkamp E., et al., 1989
Promoter
Name: hemAp2
+1: 1263583
Distance from start of the gene: 131
Sequence: acgttgcagttataacccttaatgctagcgttaccgtccgctatcgtctatgttcaagttGtcttaattgccagaatctaa
Evidence: [TIM]
Reference(s): [2] Choi P., et al., 1996
[1] Verkamp E., et al., 1989


Transcription unit          
Name: hemA-prfA-prmC
Gene(s): hemA, prfA, prmC   Genome Browser M3D Gene expression COLOMBOS
Note(s): A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for prmC . This structure could regulate the expression of the gene, as observed for hemL gene expression Shao X, Zhang W, Umar MI, Wong HY, Seng Z, Xie Y, Zhang Y, Yang L, Kwok CK, Deng X,2020.
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [3] Dahlgren A., et al., 2004
[1] Verkamp E., et al., 1989
Promoter
Name: hemAp1
+1: 1263676
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 38
Sequence: attactccaaaagggggcgctctcttttattgatcttacgcatcctgtatgatgcaagcaGactaaccctatcaacgttgg
                          -35                   -10         +1                   
Evidence: [ICWHO]
[TIM]
Reference(s): [2] Choi P., et al., 1996
[4] Huerta AM., et al., 2003
[1] Verkamp E., et al., 1989
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd ArcA-phosphorylated activator hemAp1 nd nd nd nd nd [GEA], [BPP] [2], [5]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal FNR repressor hemAp1 1263645 1263658 -24.5 ctctcttttaTTGATCTTACGCATcctgtatgat nd [GEA], [BPP] [2], [5]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd IHF activator hemAp1 nd nd nd nd nd [GEA], [BPP] [5]





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