RegulonDB RegulonDB 11.1: Operon Form
   

mcbA operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: mcbA
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: mcbA
Gene(s): mcbA   Genome Browser M3D Gene expression COLOMBOS
Note(s): The mcbA gene was significantly upregulated in bacterial cells associated with lettuce roots in a microarray analysis Hou Z,2012.
Evidence: [COMP-AINF] Inferred computationally without human oversight
Promoter
Name: mcbAp5
+1: 842153
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 97
Sequence: aaaaatcagcattatgcatgtcattgatttgtcttattttgtaaaaatatatcgttcaaaAaataagcacatctctgtcaa
                             -35                       -10  +1                   
Evidence: [COMP-AINF]
Reference(s): [1] Huerta AM., et al., 2003
TF binding sites (TFBSs)
[McbR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd McbR repressor mcbAp5 nd nd nd nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] W [2]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis

 [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] Binding of purified proteins


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Zhang XS., Garcia-Contreras R., Wood TK., 2008, Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA)., ISME J 2(6):615-31

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