RegulonDB RegulonDB 10.8: Operon Form
   

murR operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: murR
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: murR
Gene(s): murR   Genome Browser M3D Gene expression COLOMBOS
Note(s): murR and murQ are divergently orientated and expressed from nonoverlapping face-to-face (convergent) promoters, and their transcripts are complementary at the 5' end. CRP controls positively murQP expression and it also may affect murR transcription as a consequence of this unusual promoter arrangement (face-to-face) Jaeger T,2008
CRP and MurR both repress murR expression beyond transcription initiation, possibly by generating a roadblock for RNA polymerase Jaeger T,2008
Autoinduction of murR is carried out by an activated form of MurR, which may be an activator form after interaction with an as yet unidentified effector, possibly a IIBC component, since most phosphorylated sugars can trigger activation of murR in a MurR-dependent manner Ishii D,2009
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: murRp
+1: 2545793
Sigma Factor: Sigma70, Sigma38
Distance from start of the gene: 184
Sequence: gcacatttccagcgtcgatacgcggtcaatttcagccgaggcggtgttcgagccttcagtAatcatcttttcaaattgcat
                             -35                  -10       +1                   
Evidence: [TIM]
Reference(s): [1] Jaeger T., et al., 2008
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote MurR activator murRp 2545911 2545925 -125.0 taacatcgatCGCCGCGGCGATATCcggcagtacg nd [APIORCISFBSCS], [CV(GEA/ROMA)], [GEA] [2]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote MurR repressor murRp 2545911 2545925 -125.0 taacatcgatCGCCGCGGCGATATCcggcagtacg nd [APIORCISFBSCS], [CV(GEA/ROMA)], [GEA] [2]





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