RegulonDB RegulonDB 10.8: Operon Form

cas3 operon and associated TUs in Escherichia coli K-12 genome

Name: cas3
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Name: cas3
Gene(s): cas3   Genome Browser M3D Gene expression COLOMBOS
Note(s): Glycine, serine, N5,N10-methylene tetrahydrofolate (N5,N10-mTHF), cAMP, CRP, or the presence of the gcvTHP operon is able to induce the expression of the cas3 gene. The gcvTHP operon produces the enzyme to degrade glycine. A product of degradation of glycine or serine is N5,N10-mTHF, which appears to affect the production of cAMP, the effector of the transcriptional regulator CRP Yang D,2020.
Evidence: [ICWHO] Inferred computationally without human oversight
Name: cas3p
+1: Unknown
Sigma Factor: Sigma70 Sigmulon
Evidence: [IHBCE]
Reference(s): [1] Yang D., et al., 2020
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd CRP-cAMP activator cas3p 2887279 2887278 nd nd nd [APIORCISFBSCS], [BPP], [CV(CHIP-SV/GEA/ROMA)], [CV(CHIP-SV/SM)], [CV(GEA/ROMA)], [CV(GEA/ROMA/SM)], [GEA], [SM] [1]

RNA cis-regulatory element    
Regulation, transcriptional elongation  
Attenuator type: Transcriptional
Strand: reverse
  Structure type Energy LeftPos RightPos Sequence (RNA-strand)
  terminator -13.1 2887329 2887374 tatcaacctgAGGCCAGCGTTCGAACCCAAACAATTCGAATGTTAGTCTCTTCTTtgcagggagg
  anti-terminator -11.1 2887371 2887401 atggacaaaaGCCCCAGGCGATATTTCTATCAACCTGAGGccagcgttcg
Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos"