RegulonDB RegulonDB 10.9: Operon Form
   

mlaFEDCB operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: mlaFEDCB
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: mlaFEDCB
Gene(s): mlaB, mlaC, mlaD, mlaE, mlaF   Genome Browser M3D Gene expression COLOMBOS
Evidence: [PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Malinverni JC., et al., 2009
Promoter
Name: mlaFp3
+1: 3340102
Distance from start of the gene: 37
Sequence: tcgctaaccacggcgggtaatattctgtaaatatgttgggttcaaggttaaattgagcgcCatgcttagaaaatcaacgca
Evidence: [TIM]
Reference(s): [2] Sharma P., et al., 2017


Transcription unit          
Name: mlaFEDCB
Gene(s): mlaB, mlaC, mlaD, mlaE, mlaF   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight
[PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Malinverni JC., et al., 2009
Promoter
Name: mlaFp2
+1: 3340121
Distance from start of the gene: 56
Sequence: gtaaaacaaatgccagctttcgctaaccacggcgggtaatattctgtaaatatgttgggtTcaaggttaaattgagcgcca
Evidence: [TIM]
Reference(s): [2] Sharma P., et al., 2017
TF binding sites (TFBSs)
[MarA,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MarA activator mlaFp2 3340155 3340170 -41.5 taaaacaaatGCCAGCTTTCGCTAACcacggcgggt nd [BPP], [GEA], [ICWHO] [2]


Transcription unit       
Name: mlaFEDCB
Gene(s): mlaB, mlaC, mlaD, mlaE, mlaF   Genome Browser M3D Gene expression COLOMBOS
Evidence: [PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Malinverni JC., et al., 2009
Promoter
Name: mlaFp1
+1: 3340132
Distance from start of the gene: 67
Sequence: gcggctaaaaagtaaaacaaatgccagctttcgctaaccacggcgggtaatattctgtaaAtatgttgggttcaaggttaa
Evidence: [TIM]
Reference(s): [2] Sharma P., et al., 2017


Evidence    

 [TIM] Transcription initiation mapping

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Malinverni JC., Silhavy TJ., 2009, An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane., Proc Natl Acad Sci U S A 106(19):8009-14

 [2] Sharma P., Haycocks JRJ., Middlemiss AD., Kettles RA., Sellars LE., Ricci V., Piddock LJV., Grainger DC., 2017, The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity., Nat Commun 8(1):1444

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