RegulonDB RegulonDB 10.8: Operon Form
   

ycgZ-ymgA-ariR-ymgC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: ycgZ-ymgA-ariR-ymgC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: ycgZ-ymgA-ariR-ymgC
Gene(s): ycgZ, ymgA, ariR, ymgC   Genome Browser M3D Gene expression COLOMBOS
Note(s): ycgZ-ymgA-ariR-ymgC constitutes an operon. YmgA and AriR activate production of the biofilm matrix substance colanic acid as well as acid resistance genes and the biofilm-associated bdm gene and they downregulate adhesive curli fimbriae Domka J,2007. 17609140. 17765265. 19172264 YcgZ appears to counteract the activities of YmgA and YmgB Tschowri N,2009
Expression of this operon is under the control of σ38 (rpoS) RNA polymerase and repressed by ycgE, which is transcribed divergently on the opposite strand Tschowri N,2009. Weber H,2005
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Tschowri N., et al., 2009
Promoter
Name: ycgZp
+1: 1215752
Sigma Factor: Sigma38, Sigma70
Distance from start of the gene: 37
Sequence: gcaaaaaattaatttatcattctgtacacatatttcgtacaagtttgctattgttacttcActtaacattgattaacattt
                         -35                -10             +1                   
Evidence: [HIPP]
[TIM]
Reference(s): [2] Gama-Castro S., et al., 2008
[3] Tschowri N., et al., 2012
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal BluR repressor ycgZp 1215713 1215733 -29.5 atttatcattCTGTACACATATTTCGTACAAgtttgctatt nd [BPP], [CV(CHIP-SV/SM)], [GEA], [SM] [1], [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal MarA1 activator ycgZp 1215683 1215698 -62.0 atatgcattaGCACTAATTGCAAAAAattaatttat nd [AIBSCS], [BPP], , [CV(CHIP-SV/SM)], [SM] [4]
Note(s): 1The ycgZp promoter is recognized by both σ70- and σ38-associated RNA polymerase. The marbox position is important for σ70-dependent activation of the ycgZp promoter Kettles RA,2019. On the other hand, MarA activates σ38-dependent transcription from a ycgZp promoter derivative with a repositioned marbox Kettles RA,2019.
MarA regulates the ycgZ-ymgA-ariR-ymgC operon for inhibition of biofilm formation and Curli fiber formation, and it is required for induction by salicylic acid in vivo Kettles RA,2019.1The ycgZp promoter is recognized by both σ70- and σ38-associated RNA polymerase. The marbox position is important for σ70-dependent activation of the ycgZp promoter Kettles RA,2019. On the other hand, MarA activates σ38-dependent transcription from a ycgZp promoter derivative with a repositioned marbox Kettles RA,2019.
MarA regulates the ycgZ-ymgA-ariR-ymgC operon for inhibition of biofilm formation and Curli fiber formation, and it is required for induction by salicylic acid in vivo Kettles RA,2019.


Transcription unit       
Gene(s): ymgA, ariR   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight


Transcription unit       
Gene(s): ycgZ   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight


Transcription unit       


Transcription unit       
Gene(s): ymgC   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight





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