RegulonDB RegulonDB 11.1: Operon Form

dosCP operon and associated TUs in Escherichia coli K-12 genome

Name: dosCP
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit       
Name: dosCP
Synonym(s): yddV-dos
Gene(s): dosP, dosC   Genome Browser M3D Gene expression COLOMBOS
Note(s): The dosCP operon is highly expressed at low growth temperatures and in the stationary phase, and it plays an important role in the expression of curli-encoding genes in aerobically growing cells Tagliabue L, Maciag A, Antoniani D, Landini P,2010.
The products of the dosCP operon, diguanylate cyclase (DGC) and c-di-GMP phosphodiesterase, heme-regulated (c-PDE), act as an oxygen sensor protein complex and regulate the transcription of the csgBAC operon in response to oxygen availability Tagliabue L, Maciag A, Antoniani D, Landini P,2010.
The dosCP operon is the most highly expressed among σS-dependent genes encoding enzymes related to c-di-GMP metabolism Weber H,2006. Sommerfeldt N,2009.
Evidence: [EXP-IDA-TRANSCRIPT-LEN-DETERMINATION] Length of transcript experimentally determined
[EXP-IEP-COREGULATION] Inferred through co-regulation
Reference(s): [1] Jonas K., et al., 2008
[2] Mendez-Ortiz MM., et al., 2006
Type: rho-independent
Sequence: aaatcacagtATTTAAGTGACAGTGTCACGTTAAATgaaaacccgc
Reference(s): [3] Lessard IA., et al., 1998

RNA cis-regulatory element    
Regulation, transcriptional elongation  
Attenuator type: Transcriptional
Strand: reverse
  Structure type Energy LeftPos RightPos Sequence (RNA-strand)
  terminator -6.9 1567012 1567043 attgccgttgCGCATGCTCATTATCTGAGTATCGAGTTTTAtcgaattgtc
  anti-terminator -11.1 1567038 1567071 tccgcccattCGTGCTAAAGCCGCGGAAATTGCCGTTGCGCATgctcattatc
  anti-anti-terminator -7.6 1567073 1567102 atgagtggacCGGACTTGTCGAACAGGCAGATCCGCCCAttcgtgctaa
Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos"