RegulonDB RegulonDB 10.8: Operon Form
   

torR operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: torR
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: torR
Gene(s): torR   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Ansaldi M., et al., 2000
Promoter
Name: torRp
+1: 1057984
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 30
Sequence: aatgagcaaatatgaacagcggcactggtcaggatgaacggcttacggcagaatatgaacAgatatgaacagaatgagtaa
                          -35                    -10        +1                   
Evidence: [HIPP]
[TIM]
Reference(s): [1] Ansaldi M., et al., 2000
[2] Simon G., et al., 1994
TF binding sites (TFBSs)
[TorR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal TorR1 repressor torRp 1057973 1057982 7.5 atatgaacagATATGAACAGaatgagtaaa nd [APIORCISFBSCS], [BCE], [BPP], [CV(CHIP-SV/GEA/GS)], [CV(CHIP-SV/GEA/ROMA)], [CV(CHIP-SV/SM)], [CV(GEA/GS)], [CV(GEA/ROMA)], [CV(GEA/ROMA/SM)], [CV(GEA/SM/GS)], [GEA], [GS], [SM] [1], [3], [4]
proximal TorR2 repressor torRp 1057983 1057992 -3.5 ttacggcagaATATGAACAGatatgaacag nd [APIORCISFBSCS], [BCE], [BPP], [CV(CHIP-SV/GEA/GS)], [CV(CHIP-SV/GEA/ROMA)], [CV(GEA/GS)], [CV(GEA/ROMA)], [GEA], [GS] [1], [3], [4]
Note(s): 1It seems that TorR is able to regulate itself in an unphosphorylated conformation, because it autorepresses well in the absence of phosphate donors such as trimethylamine N-oxide (TMAO) and TorS Ansaldi M,2000.
2It seems that TorR is able to regulate itself in an unphosphorylated conformation, because it autorepresses well in the absence of phosphate donors such as trimethylamine N-oxide (TMAO) and TorS Ansaldi M,2000.1It seems that TorR is able to regulate itself in an unphosphorylated conformation, because it autorepresses well in the absence of phosphate donors such as trimethylamine N-oxide (TMAO) and TorS Ansaldi M,2000.
2It seems that TorR is able to regulate itself in an unphosphorylated conformation, because it autorepresses well in the absence of phosphate donors such as trimethylamine N-oxide (TMAO) and TorS Ansaldi M,2000.


Evidence    

 [HIPP] Human inference of promoter position

 [TIM] Transcription initiation mapping

 [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [BCE] Binding of cellular extracts

 [BPP] Binding of purified proteins

 [CV(CHIP-SV/GEA/GS)] cross validation(CHIP-SV/GEA/GS)

 [CV(CHIP-SV/GEA/ROMA)] cross validation(CHIP-SV/GEA/ROMA)

 [CV(CHIP-SV/SM)] cross validation(CHIP-SV/SM)

 [CV(GEA/GS)] cross validation(GEA/GS)

 [CV(GEA/ROMA)] cross validation(GEA/ROMA)

 [CV(GEA/ROMA/SM)] cross validation(GEA/ROMA/SM)

 [CV(GEA/SM/GS)] cross validation(GEA/SM/GS)

 [GEA] Gene expression analysis

 [GS] genomic SELEX

 [SM] Site mutation


Reference(s)    

 [1] Ansaldi M., Simon G., Lepelletier M., Mejean V., 2000, The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli., J Bacteriol 182(4):961-6

 [2] Simon G., Mejean V., Jourlin C., Chippaux M., Pascal MC., 1994, The torR gene of Escherichia coli encodes a response regulator protein involved in the expression of the trimethylamine N-oxide reductase genes., J Bacteriol 176(18):5601-6

 [3] Shimada T., Ogasawara H., Ishihama A., 2018, Single-target regulators form a minor group of transcription factors in Escherichia coli K-12., Nucleic Acids Res 46(8):3921-3936

 [4] Simon G., Jourlin C., Ansaldi M., Pascal MC., Chippaux M., Mejean V., 1995, Binding of the TorR regulator to cis-acting direct repeats activates tor operon expression., Mol Microbiol 17(5):971-80

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