RegulonDB RegulonDB 10.10: Operon Form
   

torR operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: torR
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: torR
Gene(s): torR   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [1] Ansaldi M., et al., 2000
Promoter
Name: torRp
+1: 1057984
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 30
Sequence: aatgagcaaatatgaacagcggcactggtcaggatgaacggcttacggcagaatatgaacAgatatgaacagaatgagtaa
                          -35                    -10        +1                   
Evidence: [HIPP]
[ICWHO]
[IHBCE]
[TIM]
Reference(s): [1] Ansaldi M., et al., 2000
[2] Huerta AM., et al., 2003
[3] Simon G., et al., 1994
TF binding sites (TFBSs)
[TorR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal TorR repressor torRp 1057973 1057982 7.5 atatgaacagATATGAACAGaatgagtaaa nd [GEA], [APIORCISFBSCS], [BCE], [BPP], [GS], [SM] [1], [4], [5]
proximal TorR repressor torRp 1057983 1057992 -3.5 ttacggcagaATATGAACAGatatgaacag nd [GEA], [APIORCISFBSCS], [BCE], [BPP], [GS] [1], [4], [5]


Evidence    

 [HIPP] Human inference of promoter position

 [ICWHO] Inferred computationally without human oversight

 [IHBCE] Inferred by a human based on computational evidence

 [TIM] Transcription initiation mapping

 [GEA] Gene expression analysis

 [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [BCE] Binding of cellular extracts

 [BPP] Binding of purified proteins

 [GS] genomic SELEX

 [SM] Site mutation


Reference(s)    

 [1] Ansaldi M., Simon G., Lepelletier M., Mejean V., 2000, The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli., J Bacteriol 182(4):961-6

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Simon G., Mejean V., Jourlin C., Chippaux M., Pascal MC., 1994, The torR gene of Escherichia coli encodes a response regulator protein involved in the expression of the trimethylamine N-oxide reductase genes., J Bacteriol 176(18):5601-6

 [4] Shimada T., Ogasawara H., Ishihama A., 2018, Single-target regulators form a minor group of transcription factors in Escherichia coli K-12., Nucleic Acids Res 46(8):3921-3936

 [5] Simon G., Jourlin C., Ansaldi M., Pascal MC., Chippaux M., Mejean V., 1995, Binding of the TorR regulator to cis-acting direct repeats activates tor operon expression., Mol Microbiol 17(5):971-80

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