RegulonDB RegulonDB 10.9: Operon Form
   

hiuH operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: hiuH
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: hiuH
Gene(s): hiuH   Genome Browser M3D Gene expression COLOMBOS
Note(s): Transcription of the yedX (hiuH) gene is induced by high concentrations of either copper ion or hydrogen peroxide Urano H,2015
HprR activates the yedX gene in the presence of H2O2 Urano H,2017.
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: hiuHp
+1: 2038840
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 116
Sequence: cattcctgggtcctttgattatcttcaataagtagaatcttcatgaaaataatatgccatAaatcatatgttatagaaaca
                        -35                       -10       +1                   
Note(s): Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.764. P-value: 6.705e-5
Evidence: [ICWHO]
Reference(s): [1] Huerta AM., et al., 2003
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote CusR-Pasp activator hiuHp 2038870 2038886 38.5 agcctggttcATTACAAAATTGTAATGctgctgtaag nd [AIBSCS], [BPP], [GEA] [2], [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote HprR-P activator hiuHp 2038869 2038887 38.5 cagcctggttCATTACAAAATTGTAATGCtgctgtaagg nd [APIORCISFBSCS], [BPP], [GEA] [2], [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd PhoB-Phosphorylated1 activator hiuHp nd nd nd nd nd [BPP], [GEA], [IGI] [4]
Note(s): 1Yang et al. identified the binding site of PhoB Yang C,2012but did not identify the promoter regulated; therefore, there is a possibility that this binding site corresponds to another promoter, according to the function of PhoB. The binding site of this regulator, TCATTACAAAATTGTAATG, is located at bp -79 relative to the translation start site of yedX Yang C,20123Yang et al. identified the binding site of PhoB Yang C,2012but did not identify the promoter regulated; therefore, there is a possibility that this binding site corresponds to another promoter, according to the function of PhoB. The binding site of this regulator, TCATTACAAAATTGTAATG, is located at bp -79 relative to the translation start site of yedX Yang C,2012





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