RegulonDB RegulonDB 10.9:Regulon Page
   

Fis DNA-binding transcriptional dual regulator

Synonyms: Fis
Summary:
Fis, "factor for inversion stimulation", is a small DNA-binding and bending protein whose main role appears to be the organization and maintenance of nucleoid structure through direct DNA binding and by modulating gyrase [] and topoisomerase I production [64], as well as regulation of other proteins that modulate the nucleoid structure, such as CRP, HNS, and HU. Fis directly modulates several cellular processes, such as transcription, chromosomal replication, DNA inversion, phage integration/excision, and DNA transposition [1, 69]. Fis is able to form topological barriers blocking supercoiling diffusion around some promoters []. As a transcriptional regulator, Fis regulates the expression of many genes involved in translation (rRNA and tRNA genes), virulence, biofilm formation, energy metabolism, stress response, central intermediary metabolism, amino acid biosynthesis, transport, cell structure, carbon compound metabolism, amino acid metabolism, nucleotide metabolism, motility, and chemotaxis [1, 8, 70].
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
Fis Functional   [IDA], [IEP], [IPI] [1]
Evolutionary Family: EBP
Sensing class: TFs for DNA-bending
Connectivity class: Global Regulator
Gene name: fis
  Genome position: 3411271-3411567
  Length: 297 bp / 98 aa
Operon name: dusB-fis
TU(s) encoding the TF:
Transcription unit        Promoter
dusB-fis
dusBp


Regulon       
Regulated gene(s) acnB, acs, actP, adhE, alaT, alaU, alaV, alaW, alaX, aldB, ansB, apaG, apaH, argU, argW, argX, aspV, bglB, bglF, bglG, carA, carB, cbpA, cbpM, crp, cspA, cspI, cyoA, cyoB, cyoC, cyoD, cyoE, cysG, deoA, deoB, deoC, deoD, dmsA, dmsB, dmsC, dnaA, dnaN, dps, dusB, emrD, fadA, fadB, fau, fis, flxA, fumB, gadA, gadB, gadC, gadX, glcC, glnA, glnG, glnL, glnQ, glnU, glnV, glnW, glnX, glpA,
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Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
tRNA (53)
membrane (40)
anaerobic respiration (40)
translation (29)
ribosomes (28)
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Regulated operon(s) abgABT-ogt, acnB, acs-yjcH-actP, adhE, alaWX, aldB, ansB, argU, argW, argX-hisR-leuT-proM, aspV, bdm-sra, bglGFB, carAB, cbpAM, crp, cspA, cspI, cyoABCDE, dcuB-fumB, deoCABD, dmsABC, dnaAN-recF, dps, dusB-fis, emrD, fadBA, flxA, focA-pflB, gadAXW, gadBC, garPLRK-rnpB, glcC, glnALG, glnHPQ, glpABC, glpTQ, gltX, glyU, grcA, guaBA, gyrA, gyrB, hlyE, hns, hupA, hupB, hyaABCDEF, katE, leuQPV, leuX, lptD-surA-pdxA-rsmA-apaGH, lysT-valT-lysW, malEFG, marRAB, metT-leuW-glnUW-metU-glnVX, metY-rimP-nusA-infB-rbfA-truB-rpsO-pnp, mglBAC, msrA, mtlADR, nanATEK-yhcH, narGHJI, narK, ndh, nirBDC-cysG,
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First gene in the operon(s) acnB, acs, adhE, alaW, aldB, ansB, argU, argW, argX, aspV, bglG, carA, cbpA, crp, cspA, cspI, cyoA, deoC, dmsA, dnaA, dps, dusB, emrD, fadB, flxA, fumB, gadA, gadB, glcC, glnA, glnQ, glpA, glpT, gltX, glyU, grcA, guaB, gyrA, gyrB, hlyE, hns, hupA, hupB, hyaA, katE, leuQ, leuX, lpd, lysT, malE, marR, mazE, metT, metY, mglA, msrA, mtlA, nanA, narG, narK, ndh, nirB, nrdA, nrfA, nuoA,
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Simple and complex regulons AcrR,CRP,CpxR,Cra,Fis,MarA,MarR,Rob,SoxS
AdiY,ArcA,CRP,FNR,Fis,GadE-RcsB,GadW,GadX,H-NS,RcsB,TorR
AdiY,ArcA,CRP,FNR,Fis,GadE-RcsB,GadW,GadX,H-NS,RcsB,TorR,ppGpp
AdiY,CRP,Fis,FliZ,GadE,GadW,GadX,RcsB
AppY,ArcA,Fis,IscR,NarL,NarP,YdeO
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Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[Fis,-](63)
[Fis,+](68)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  Fis repressor acnBp Sigma70 -171.5 -267.5 acnB
aagaggcggtAGTTTAAATTTTGACTaatcttggga
131340 131354 [APIORCISFBSCS], [GEA] [2]
  Fis repressor acnBp Sigma70 -73.5 -169.5 acnB
tctagaccatCCTTAACGATTCAGCCacttttttat
131438 131452 [APIORCISFBSCS], [GEA] [2]
  Fis repressor acnBp Sigma70 -29.5 -125.5 acnB
tttgtaaacaGATTAACACCTCGTCAaaatcctgct
131482 131496 [APIORCISFBSCS], [GEA] [2]
  Fis repressor acsp Sigma38 -265.0 -285.0 acs, yjcH, actP
ctcgcccctaTGTGTAACAAATAACCacactgtgaa
4287649 4287663 [BPP], [GEA] [3], [4], [5]
  Fis repressor acsp Sigma38 -98.0 -118.0 acs, yjcH, actP
aaaattacccTGCCGTTTATTTGCACaattctactt
4287482 4287496 [AIBSCS], [BPP], [GEA], [SM] [3]
  Fis repressor acsp Sigma38 -59.0 -79.0 acs, yjcH, actP
cgtgatctgtCGCCCAAATACTAAACaaaactgcca
4287443 4287457 [AIBSCS], [BPP], [GEA], [SM] [3]
  Fis repressor acsp1 Sigma70 -61.0 -285.0 acs, yjcH, actP
ctcgcccctaTGTGTAACAAATAACCacactgtgaa
4287649 4287663 [BPP], [GEA] [4]
  Fis repressor acsp2 Sigma70 -265.0 -285.0 acs, yjcH, actP
ctcgcccctaTGTGTAACAAATAACCacactgtgaa
4287649 4287663 [BPP], [GEA] [3], [4], [5]
  Fis repressor acsp2 Sigma70 -98.0 -118.0 acs, yjcH, actP
aaaattacccTGCCGTTTATTTGCACaattctactt
4287482 4287496 [AIBSCS], [BPP], [GEA], [SM] [3]
  Fis repressor acsp2 Sigma70 -59.0 -79.0 acs, yjcH, actP
cgtgatctgtCGCCCAAATACTAAACaaaactgcca
4287443 4287457 [AIBSCS], [BPP], [GEA], [SM] [3]
  Fis activator adhEp Sigma38 -148.0 -440.0 adhE
agccggataaTGTTAGCCATAAATAAggttgaaaag
1298554 1298568 [APIORCISFBSCS], [BPP], [GEA] [6]
  Fis activator adhEp Sigma38 -68.0 -360.0 adhE
ctacttaaaaTTGCTATCATTCGTTAttgttatcta
1298474 1298488 [APIORCISFBSCS], [BPP], [GEA] [6]
  Fis activator adhEp Sigma38 -42.0 -334.0 adhE
ttgttatctaGTTGTGCAAAACATGCtaatgtagcc
1298448 1298462 [APIORCISFBSCS], [BPP], [GEA] [6]
  Fis activator adhEp1 Sigma70 -148.0 -440.0 adhE
agccggataaTGTTAGCCATAAATAAggttgaaaag
1298554 1298568 [APIORCISFBSCS], [BPP], [GEA] [6]
  Fis activator adhEp1 Sigma70 -68.0 -360.0 adhE
ctacttaaaaTTGCTATCATTCGTTAttgttatcta
1298474 1298488 [APIORCISFBSCS], [BPP], [GEA] [6]
  Fis activator adhEp1 Sigma70 -42.0 -334.0 adhE
ttgttatctaGTTGTGCAAAACATGCtaatgtagcc
1298448 1298462 [APIORCISFBSCS], [BPP], [GEA] [6]
  Fis activator alaWp Sigma70 -76.0 -98.0 alaW, alaX
aattgttcatTTGCCTGATTTTTCAGcgattgaaac
2518322 2518336 [BCE]
  Fis repressor aldBp Sigma38 -158.0 -182.0 aldB
gaagaaattgTGGCGATTTATCGCGCagcgatgtaa
3756686 3756700 [APIORCISFBSCS], [BPP], [GEA] [7]
  Fis repressor aldBp Sigma38 -135.0 -159.0 aldB
cgcagcgatgTAATCATCATTTCCACaacggctggc
3756663 3756677 [APIORCISFBSCS], [BPP], [GEA] [7]
  Fis repressor aldBp Sigma38 -113.0 -137.0 aldB
ccacaacggcTGGCAAATTGTTAGCCgctttttcaa
3756641 3756655 [AIBSCS], [BPP], [GEA] [7]
  Fis repressor aldBp Sigma38 -48.0 -72.0 aldB
gtgatagctgTCGTAAAGCTGTTACCgactggcgaa
3756576 3756590 [AIBSCS], [BPP], [GEA] [7]
  Fis repressor aldBp Sigma38 -29.0 -53.0 aldB
tgttaccgacTGGCGAAGATTTCGCCagtcacgtct
3756557 3756571 [AIBSCS], [BPP], [GEA] [7]
  Fis repressor ansBp1 nd -69.0 -131.0 ansB
ttttttatgcCGTTTAATTCTTCGTTttgttacctg
3100852 3100866 [AIBSCS], [GEA] [8]
  Fis repressor ansBp1 nd -27.0 -89.0 ansB
actttgtagaTCTCCAAAATATATTCacgttgtaaa
3100810 3100824 [AIBSCS], [GEA] [8]
  Fis activator argUp Sigma70 -65.0 -85.0 argU
cagacgcggtCGTTCACTTGTTCAGCaaccagatca
564631 564645 [IHBCE]
  Fis activator argWp Sigma70 -74.0 -75.0 argW
ataaaaacccGGCATAAATGGCGAGGgtttaagcaa
2466227 2466241 [BCE]
  Fis activator argXp Sigma70 -75.0 -86.0 argX, hisR, leuT, proM
agcagcaaaaCGCACAAACCGTAACCaaacgcgcaa
3982282 3982296 [BCE]
  Fis activator aspVp Sigma70 -76.0 -94.0 aspV
aatagcgactTGGGCGATTTTTGCAGcaaacgattc
236830 236844 [BCE]
  Fis repressor bglGp nd -52.0 -182.0 bglG, bglF, bglB
ctgcgagcatGGTCATATTTTTATCAatagcgcatt
3906742 3906756 [BPP] [9]
  Fis repressor bglGp nd -27.0 -157.0 bglG, bglF, bglB
aatagcgcatTGCTATTTTCTCTGCAcgcaattaaa
3906717 3906731 [BPP] [9]
  Fis activator carAp1 Sigma70 -156.0 -256.0 carA, carB
ttttttctgcTCGTTTTTATTTCATGCAATcttcttgctg
29386 29405 [AIBSCS], [GEA] [8]
  Fis activator carAp1 Sigma70 -103.0 -203.0 carA, carB
cagaacaggtTAGATGATCTTTTTGTCGCTtaatgcctgt
29439 29458 [AIBSCS], [GEA] [8]
  Fis activator carAp1 Sigma70 -81.0 -181.0 carA, carB
ttgtcgcttaATGCCTGTAAAACATGCATGagccacaaaa
29461 29480 [AIBSCS], [GEA] [8]
  Fis repressor cbpAp Sigma38 104.0 -159.0 cbpA, cbpM
ctttttcaccTGTTTAAAATATGTTCagcaacccat
1063927 1063941 [APIORCISFBSCS], [BPP], [GEA], [SM], [APIORCISFBSCS], [BPP], [GEA], [SM] [10]
  Fis repressor cbpAp4 Sigma70 -15.0 -159.0 cbpA, cbpM
ctttttcaccTGTTTAAAATATGTTCagcaacccat
1063927 1063941 [APIORCISFBSCS], [BPP], [GEA], [SM] [10]
  Fis repressor cbpAp6 Sigma70 104.0 -159.0 cbpA, cbpM
ctttttcaccTGTTTAAAATATGTTCagcaacccat
1063927 1063941 [APIORCISFBSCS], [BPP], [GEA], [SM], [APIORCISFBSCS], [BPP], [GEA], [SM] [10]
  Fis repressor crpp1 Sigma70 -92.0 -259.0 crp
tcctgacagaGTACGCGTACTAACCAaatcgcgcaa
3485854 3485868 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp1 Sigma70 31.0 -137.0 crp
tacattgatgTACTGCATGTATGCAAaggacgtcac
3485976 3485990 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp1 Sigma70 49.0 -119.0 crp
gtatgcaaagGACGTCACATTACCGTgcagtacagt
3485994 3486008 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp1 Sigma70 69.0 -99.0 crp
taccgtgcagTACAGTTGATAGCCCCttcccaggta
3486014 3486028 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp2 nd -170.0 -259.0 crp
tcctgacagaGTACGCGTACTAACCAaatcgcgcaa
3485854 3485868 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp2 nd -49.0 -138.0 crp
atacattgatGTACTGCATGTATGCAaaggacgtca
3485975 3485989 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp2 nd -31.0 -120.0 crp
tgtatgcaaaGGACGTCACATTACCGtgcagtacag
3485993 3486007 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp2 nd -11.0 -100.0 crp
ttaccgtgcaGTACAGTTGATAGCCCcttcccaggt
3486013 3486027 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp3 nd -164.0 -259.0 crp
tcctgacagaGTACGCGTACTAACCAaatcgcgcaa
3485854 3485868 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp3 nd -43.0 -138.0 crp
atacattgatGTACTGCATGTATGCAaaggacgtca
3485975 3485989 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp3 nd -25.0 -120.0 crp
tgtatgcaaaGGACGTCACATTACCGtgcagtacag
3485993 3486007 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis repressor crpp3 nd -5.0 -100.0 crp
ttaccgtgcaGTACAGTTGATAGCCCcttcccaggt
3486013 3486027 [APIORCISFBSCS], [BPP], [GEA] [11]
  Fis activator cspAp1 Sigma70 -126.0 -286.0 cspA
taagtaagcaGTTGATGGAATAGACTtttatccact
3719756 3719770 [AIBSCS], [BPP], [GEA] [12]
  Fis activator cspAp1 Sigma70 -72.0 -232.0 cspA
ctgatgacagGACCGTTTTCCAACCGattaatcata
3719810 3719824 [AIBSCS], [BPP], [GEA] [12]
  Fis activator cspAp1 Sigma70 12.0 -149.0 cspA
cacatcaacgGTTTGACGTACAGACCattaaagcag
3719893 3719907 [AIBSCS], [BPP], [GEA] [12]
  Fis activator cspAp1 Sigma70 87.0 -74.0 cspA
ccctcgtagtGCACATTCCTTTAACGcttcaaaatc
3719968 3719982 [AIBSCS], [BPP], [GEA] [12]
  Fis activator cspAp1 Sigma70 119.0 -42.0 cspA
aatctgtaaaGCACGCCATATCGCCGaaaggcacac
3720000 3720014 [AIBSCS] [13]
  Fis repressor cspIp nd -88.0 -233.0 cspI
cagaatgacaCGTTTTATTAATAAATaaagctattc
1638893 1638907 [AIBSCS], [GEA] [8]
  Fis repressor cspIp nd -83.0 -228.0 cspI
tgacacgtttTATTAATAAATAAAGCtattctttca
1638888 1638902 [AIBSCS], [GEA] [8]
  Fis repressor cspIp nd -20.0 -165.0 cspI
tccttgctatGGGTGGTTAATCATGCgttaatggtg
1638825 1638839 [AIBSCS], [GEA] [8]
  Fis repressor cspIp nd 14.0 -132.0 cspI
gtgttctggtTTGTTACAAATTTATCtgaagcagtc
1638792 1638806 [AIBSCS], [GEA] [8]
  Fis repressor cspIp nd 41.0 -105.0 cspI
gaagcagtcaTTGTTATAATTTTATTatttgtacct
1638765 1638779 [AIBSCS], [GEA] [8]
  Fis repressor cspIp nd 49.0 -97.0 cspI
cattgttataATTTTATTATTTGTACctcttgagat
1638757 1638771 [AIBSCS], [GEA] [8]
  Fis activator cyoAp Sigma70 nd nd cyoA, cyoB, cyoC, cyoD, cyoE nd nd [BPP], [GEA], [IGI] [8]
  Fis activator deoCp2 Sigma70 -102.0 -147.0 deoC, deoA, deoB, deoD
tcatttgaaaGTGAATTATTTGAACCagatcgcatt
4617169 4617183 [AIBSCS], [GEA] [14]
  Fis repressor dmsAp1 Sigma70 -33.0 -169.0 dmsA, dmsB, dmsC
ctttgataccGAACAATAATTACTCCtcacttacac
940783 940797 [AIBSCS], [GEA] [8]
  Fis repressor dmsAp1 Sigma70 8.0 -129.0 dmsA, dmsB, dmsC
aatactacttTCGAGTGAAAATCTACCTATctctttgatt
940821 940840 [AIBSCS], [GEA] [8]
  Fis repressor dmsAp1 Sigma70 59.0 -78.0 dmsA, dmsB, dmsC
atgtatacaaGCCTATATAGCGAACTgctatagaaa
940874 940888 [AIBSCS], [GEA] [8]
  Fis repressor dnaAp2 Sigma70 -26.0 -179.0 dnaA, dnaN, recF
tgtgagaaacAGAAGATCTCTTGCGCagtttaggct
3883901 3883915 [APIORCISFBSCS], [BPP], [GEA] [15]
  Fis repressor dpsp Sigma70 -26.0 -65.0 dps
cagccagaatAGCGGAACACATAGCCggtgctatac
848969 848983 [APIORCISFBSCS], [BPP], [GEA] [16], [17]
  Fis repressor dpsp Sigma70 -10.0 -49.0 dps
acacatagccGGTGCTATACTTAATCtcgttaatta
848953 848967 [APIORCISFBSCS], [BPP], [GEA] [16], [17]
  Fis repressor dpsp2 Sigma38 -26.0 -65.0 dps
cagccagaatAGCGGAACACATAGCCggtgctatac
848969 848983 [APIORCISFBSCS], [BPP], [GEA] [16], [17]
  Fis repressor dpsp2 Sigma38 -10.0 -49.0 dps
acacatagccGGTGCTATACTTAATCtcgttaatta
848953 848967 [APIORCISFBSCS], [BPP], [GEA] [16], [17]
  Fis repressor dusBp Sigma70 -221.0 -255.0 dusB, fis
acgtaaatttGCCGATTATTTACGCAaatttgcgtg
3410018 3410032 [APIORCISFBSCS], [BPP], [GEA] [18]
  Fis repressor dusBp Sigma70 -143.0 -177.0 dusB, fis
atttctttgaGTGTAAATTTTAGTCActattttcta
3410096 3410110 [APIORCISFBSCS], [BPP], [GEA] [18]
  Fis repressor dusBp Sigma70 -101.0 -135.0 dusB, fis
tgatttttatGAGTAATTATCGCACCacgctcattt
3410138 3410152 [APIORCISFBSCS], [BPP], [GEA] [18]
  Fis repressor dusBp Sigma70 -83.0 -117.0 dusB, fis
atcgcaccacGCTCATTTTAAATGCAattctttgat
3410156 3410170 [APIORCISFBSCS], [GEA], [SM] [19]
  Fis repressor dusBp Sigma70 -42.0 -76.0 dusB, fis
tcagaggattGGTCAAAGTTTGGCCTttcatctcgt
3410197 3410211 [APIORCISFBSCS], [GEA], [SM] [19]
  Fis repressor dusBp Sigma70 26.0 -9.0 dusB, fis
gtcacagtatGGTCATTTCTTAACTCatgcgcatcg
3410264 3410278 [APIORCISFBSCS], [GEA], [SM] [19]
  Fis activator emrDp Sigma54 nd nd emrD nd nd [BPP], [GEA], [IGI] [20]
  Fis activator fadBp Sigma70 -27.0 -69.0 fadB, fadA
taatcttttgTTTGCATATTTTTAACACAAaatacacact
4031031 4031050 [AIBSCS], [GEA] [8]
  Fis activator flxAp Sigma28 -72.0 -89.0 flxA
agcccgcgagGAAAACAATCTGAACAtcaaacaatt
1646309 1646323 [AIBSCS], [GEA] [8]
  Fis repressor fumBp Sigma70 nd nd fumB nd nd [BPP], [GEA], [IGI] [21]
  Fis repressor gadAp Sigma70 -147.0 -174.0 gadA, gadX
aacagcaatgTTTGGGCGATTTTTATTACGataataaagt
3667745 3667764 [AIBSCS], [GEA] [8]
  Fis repressor gadAp Sigma70 -118.0 -145.0 gadA, gadX
gataataaagTCTGTTTTTAATATTATCATgttaaatgtt
3667716 3667735 [AIBSCS], [GEA] [8]
  Fis repressor gadAp Sigma70 -94.0 -121.0 gadA, gadX
tatcatgttaAATGTTTATATTATAAAAAGtcgtttttct
3667692 3667711 [AIBSCS], [GEA] [8]
  Fis repressor gadAp Sigma70 -18.0 -45.0 gadA, gadX
ccttgcttccATTGCGGATAAATCCTACTTttttattgcc
3667616 3667635 [AIBSCS], [GEA] [8]
  Fis repressor gadAp2 Sigma38 -147.0 -174.0 gadA, gadX
aacagcaatgTTTGGGCGATTTTTATTACGataataaagt
3667745 3667764 [AIBSCS], [GEA] [8]
  Fis repressor gadAp2 Sigma38 -118.0 -145.0 gadA, gadX
gataataaagTCTGTTTTTAATATTATCATgttaaatgtt
3667716 3667735 [AIBSCS], [GEA] [8]
  Fis repressor gadAp2 Sigma38 -94.0 -121.0 gadA, gadX
tatcatgttaAATGTTTATATTATAAAAAGtcgtttttct
3667692 3667711 [AIBSCS], [GEA] [8]
  Fis repressor gadAp2 Sigma38 -18.0 -45.0 gadA, gadX
ccttgcttccATTGCGGATAAATCCTACTTttttattgcc
3667616 3667635 [AIBSCS], [GEA] [8]
  Fis repressor gadBp Sigma70 -105.0 -132.0 gadB, gadC
tgtttttcaaTGAAAAAATATTATTCgcgtaatatc
1572170 1572184 [AIBSCS], [GEA] [8]
  Fis repressor gadBp Sigma70 -59.0 -86.0 gadB, gadC
taacattaggATTTTGTTATTTAAACacgagtcctt
1572124 1572138 [AIBSCS], [GEA] [8]
  Fis repressor gadBp Sigma70 -27.0 -54.0 gadB, gadC
cctttgcactTGCTTACTTTATCGATaaatcctact
1572092 1572106 [AIBSCS], [GEA] [8]
  Fis repressor gadBp Sigma70 37.0 10.0 gadB, gadC
gagtttaaaaTGGATAAGAAGCAAGTaacggattta
1572029 1572043 [AIBSCS], [GEA] [8]
  Fis repressor gadBp2 Sigma38 -105.0 -132.0 gadB, gadC
tgtttttcaaTGAAAAAATATTATTCgcgtaatatc
1572170 1572184 [AIBSCS], [GEA] [8]
  Fis repressor gadBp2 Sigma38 -59.0 -86.0 gadB, gadC
taacattaggATTTTGTTATTTAAACacgagtcctt
1572124 1572138 [AIBSCS], [GEA] [8]
  Fis repressor gadBp2 Sigma38 -27.0 -54.0 gadB, gadC
cctttgcactTGCTTACTTTATCGATaaatcctact
1572092 1572106 [AIBSCS], [GEA] [8]
  Fis repressor gadBp2 Sigma38 37.0 10.0 gadB, gadC
gagtttaaaaTGGATAAGAAGCAAGTaacggattta
1572029 1572043 [AIBSCS], [GEA] [8]
  Fis repressor glcCp Sigma70 -120.0 -186.0 glcC
ctgcttctgtGAACAGTTATTAAGCGggcttttcgt
3128079 3128093 [AIBSCS], [GEA] [8]
  Fis repressor glcCp Sigma70 -90.0 -156.0 glcC
tttcgttttcGTCTATCTCTTTAGCTaccggtcaga
3128109 3128123 [AIBSCS], [GEA] [8]
  Fis repressor glcCp Sigma70 -66.0 -132.0 glcC
ctaccggtcaGACCATTTTTTTTCCAgctctgtgac
3128133 3128147 [AIBSCS], [GEA] [8]
  Fis repressor glcCp Sigma70 72.0 6.0 glcC
cgaggtccggGAATGAAAGATGAACGtcgccctatt
3128270 3128284 [AIBSCS], [GEA] [8]
  Fis activator glnAp2 Sigma54 -55.0 -128.0 glnA, glnL, glnG
tgcacgatggTGCGCATGATAACGCCttttaggggc
4058155 4058169 [AIBSCS], [BPP], [GEA] [22]
  Fis repressor glnQp Sigma70 nd nd glnQ nd nd [BPP], [GEA], [IGI] [23]
  Fis activator glpABCp Sigma70 -180.0 -244.0 glpA, glpB, glpC
gtggcccgtgGTCTTATTTATGATTAacagcctgat
2352396 2352410 [AIBSCS], [GEA] [8]
  Fis activator glpABCp Sigma70 -116.0 -180.0 glpA, glpB, glpC
ttgccgcgatGTTAAGAAAACATTCAtaaattaaat
2352460 2352474 [AIBSCS], [GEA] [8]
  Fis activator glpABCp Sigma70 -68.0 -132.0 glpA, glpB, glpC
acacattattAAATAAGATTTACAAAatgttcaaaa
2352508 2352522 [AIBSCS], [GEA] [8]
  Fis activator glpABCp Sigma70 -61.0 -125.0 glpA, glpB, glpC
attaaataagATTTACAAAATGTTCAaaatgacgca
2352515 2352529 [AIBSCS], [GEA] [8]
  Fis activator glpABCp Sigma70 -19.0 -83.0 glpA, glpB, glpC
cacgtttcacTTTCGAATTATGAGCGaatatgcgcg
2352557 2352571 [AIBSCS], [GEA] [8]
  Fis activator glpABCp Sigma70 35.0 -30.0 glpA, glpB, glpC
tttttactatGGCTAAATGGTAAAAAacgaacttca
2352610 2352624 [AIBSCS], [GEA] [8]
  Fis activator glpTQp Sigma70 -166.0 -243.0 glpT, glpQ
tgaagttcgtTTTTTACCATTTAGCCatagtaaaaa
2352610 2352624 [AIBSCS], [GEA], [AIBSCS], [GEA] [8]
  Fis activator glpTQp Sigma70 -113.0 -190.0 glpT, glpQ
cgcgcatattCGCTCATAATTCGAAAgtgaaacgtg
2352557 2352571 [AIBSCS], [GEA], [AIBSCS], [GEA] [8]
  Fis activator glpTQp Sigma70 -71.0 -148.0 glpT, glpQ
tgcgtcatttTGAACATTTTGTAAATcttatttaat
2352515 2352529 [AIBSCS], [GEA], [AIBSCS], [GEA] [8]
  Fis activator glpTQp Sigma70 -64.0 -141.0 glpT, glpQ
ttttgaacatTTTGTAAATCTTATTTaataatgtgt
2352508 2352522 [AIBSCS], [GEA], [AIBSCS], [GEA] [8]
  Fis activator glpTQp Sigma70 -16.0 -93.0 glpT, glpQ
atttaatttaTGAATGTTTTCTTAACatcgcggcaa
2352460 2352474 [AIBSCS], [GEA], [AIBSCS], [GEA] [8]
  Fis activator glpTQp Sigma70 49.0 -29.0 glpT, glpQ
atcaggctgtTAATCATAAATAAGACcacgggccac
2352396 2352410 [AIBSCS], [GEA], [AIBSCS], [GEA] [8]
  Fis repressor gltXp3 Sigma70 -121.0 -179.0 gltX
attgttcgttCGTCGTAAATTTAAGCaagatgatcg
2520844 2520858 [AIBSCS], [BCE], [BPP], [SM] [24]
  Fis repressor gltXp3 Sigma70 -101.0 -159.0 gltX
ttaagcaagaTGATCGCAAAACAGACcgtgttgcgc
2520824 2520838 [AIBSCS], [APIORCISFBSCS], [BPP], [SM] [24]
  Fis repressor gltXp3 Sigma70 -80.0 -138.0 gltX
cagaccgtgtTGCGCAATTTGTCAACgaaaacaata
2520803 2520817 [AIBSCS], [BPP], [SM] [24]
  Fis activator glyUp Sigma70 -67.0 -74.0 glyU
agccaaaatgCTGATGGCGAATTAATcagcagtcag
2999124 2999138 [BCE]
  Fis activator grcAp1 Sigma70 -159.0 -233.0 grcA
aacaaaatcaTGCTCATTTTTTAGACttaaacgagt
2716675 2716689 [AIBSCS], [GEA] [8]
  Fis activator grcAp1 Sigma70 -117.0 -191.0 grcA
aaatgtaaatTGGTAAAATTTCACACccgcataagt
2716633 2716647 [AIBSCS], [GEA] [8]
  Fis activator grcAp1 Sigma70 -10.0 -84.0 grcA
caagggtgttTGAGGAGTATATATACactcaagcaa
2716526 2716540 [AIBSCS], [GEA] [8]
  Fis repressor guaBp Sigma70 -11.0 -48.0 guaB, guaA
caatcggttaCGCTCTGTATAATGCCgcggcaatat
2634111 2634125 [AIBSCS], [BPP], [SM] [25]
  Fis repressor guaBp Sigma70 8.0 -30.0 guaB, guaA
ataatgccgcGGCAATATTTATTAACcactctggtc
2634093 2634107 [AIBSCS], [BPP], [SM] [25]
  Fis repressor guaBp Sigma70 29.0 -9.0 guaB, guaA
ttaaccactcTGGTCGAGATATTGCCcatgctacgt
2634072 2634086 [AIBSCS], [BPP] [25]
  Fis repressor gyrAp Sigma70 -42.5 -79.5 gyrA
ggatgtgaatAAAGCGTATAGGTTTAcctcaaactg
2339492 2339506 [APIORCISFBSCS], [BPP], [GEA] [26], [27]
  Fis repressor gyrBp Sigma70 -109.0 -140.0 gyrB
gcttgccagcCGCTTAAAAGCGACGCaatcacaggt
3880252 3880266 [APIORCISFBSCS], [BPP], [GEA] [26], [27]
  Fis repressor gyrBp Sigma70 -62.0 -93.0 gyrB
cgatcagtgcTGAACACGTTATAGACatgtcggacg
3880205 3880219 [APIORCISFBSCS], [BPP], [GEA] [26], [27]
  Fis repressor gyrBp2 Sigma38 -109.0 -140.0 gyrB
gcttgccagcCGCTTAAAAGCGACGCaatcacaggt
3880252 3880266 [APIORCISFBSCS], [BPP], [GEA] [26], [27]
  Fis repressor gyrBp2 Sigma38 -62.0 -93.0 gyrB
cgatcagtgcTGAACACGTTATAGACatgtcggacg
3880205 3880219 [APIORCISFBSCS], [BPP], [GEA] [26], [27]
  Fis repressor hlyEp nd -192.0 -264.0 hlyE
ctgcataggcTGCTGATTTTTCGTTCtcttatcttg
1230651 1230665 [AIBSCS], [GEA] [8]
  Fis repressor hlyEp nd -110.0 -182.0 hlyE
aaatatcaccCGGCTAAAAAATAGAAtagaagcatt
1230569 1230583 [AIBSCS], [GEA] [8]
  Fis repressor hlyEp nd -63.0 -135.0 hlyE
cattaaacatTGTTTGATATTTATCAtattaataga
1230522 1230536 [AIBSCS], [GEA] [8]
  Fis repressor hlyEp nd 9.0 -64.0 hlyE
tgaattagatGAAGTAAAATTTATTAatagttgtaa
1230451 1230465 [AIBSCS], [GEA] [8]
  Fis repressor hlyEp nd 19.0 -54.0 hlyE
gaagtaaaatTTATTAATAGTTGTAAaacaggagtt
1230441 1230455 [AIBSCS], [GEA] [8]
  Fis activator hnsp Sigma70 -282.0 -318.0 hns
cttattgcgaCTGTTCTACTTTTCATcattcgctta
1293233 1293247 [BPP] [28]
  Fis activator hnsp Sigma70 -243.0 -279.0 hns
gggaattctcGTAAACACAACTAATAcagaagactg
1293194 1293208 [BPP] [28]
  Fis activator hnsp Sigma70 -174.0 -210.0 hns
aatgtgacatGAATCAGGAAGTTTTAacctcacgtg
1293125 1293139 [BPP] [28]
  Fis activator hnsp Sigma70 -118.0 -154.0 hns
atagggctatATGCCGCGTCTTTTCTggctaatttt
1293069 1293083 [BPP] [28]
  Fis activator hnsp Sigma70 -71.0 -107.0 hns
tttattggcgGCACAAAATAAAGAACaattttgaat
1293022 1293036 [BPP] [28]
  Fis activator hnsp Sigma70 -10.0 -46.0 hns
actgaatttaAGGCTCTATTATTACCtcaacaaacc
1292961 1292975 [BPP] [28]
  Fis activator hnsp Sigma70 25.0 -12.0 hns
ccaccccaatATAAGTTTGAGATTACtacaatgagc
1292927 1292941 [BPP] [28]
  Fis activator hupAp nd -255.0 -360.0 hupA
aggctggtcgCGAAATGAGCGATGAAgagcttaaag
4199914 4199928 [BPP], [GEA] [29]
  Fis activator hupAp nd -219.5 -324.5 hupA
gaaaacccagCTGTAGAGCAAGAATGggacattcag
4199949 4199963 [BPP], [GEA] [29]
  Fis activator hupAp nd -167.5 -272.5 hupA
ttttagctgaGTGCGAAGAACGCGATatcgagctga
4200001 4200015 [BPP], [GEA] [29]
  Fis activator hupAp nd -93.5 -198.5 hupA
agcaatattgGTATAATTTTTCAGCAataagaccag
4200075 4200089 [BPP], [GEA] [29]
  Fis repressor hupBp2 Sigma70 -208.0 -264.0 hupB
gcgcattgagGAAGTTCTGACTCTGGcgctgcaaaa
461180 461194 [BPP], [GEA] [29]
  Fis repressor hupBp2 Sigma70 -185.0 -241.0 hupB
tggcgctgcaAAATGAACCGTCTGGTatgcaggttg
461203 461217 [BPP], [GEA] [29]
  Fis repressor hupBp2 Sigma70 -152.5 -208.5 hupB
gttgtgactgCAAAATAGTGACCTCGcgcaaaatgc
461235 461249 [BPP], [GEA] [29]
  Fis repressor hupBp2 Sigma70 78.0 22.0 hupB
ataaatctcaATTGATCGACAAGATTgctgcagggg
461465 461479 [BPP], [GEA] [29]
  Fis repressor hupBp3 Sigma70 -145.0 -264.0 hupB
gcgcattgagGAAGTTCTGACTCTGGcgctgcaaaa
461180 461194 [BPP], [GEA] [29]
  Fis repressor hupBp3 Sigma70 -122.0 -241.0 hupB
tggcgctgcaAAATGAACCGTCTGGTatgcaggttg
461203 461217 [BPP], [GEA]
  Fis repressor hupBp3 Sigma70 -89.5 -208.5 hupB
gttgtgactgCAAAATAGTGACCTCGcgcaaaatgc
461235 461249 [BPP], [GEA]
  Fis repressor hupBp3 Sigma70 141.0 22.0 hupB
ataaatctcaATTGATCGACAAGATTgctgcagggg
461465 461479 [BPP], [GEA] [29]
  Fis repressor hyaAp Sigma70 -21.0 -176.0 hyaA, hyaB, hyaC, hyaD, hyaE, hyaF
gtattgttttGTGCAAAAGTTTCACTacgctttatt
1031956 1031970 [AIBSCS], [GEA] [8]
  Fis repressor hyaAp2 Sigma38 -21.0 -176.0 hyaA, hyaB, hyaC, hyaD, hyaE, hyaF
gtattgttttGTGCAAAAGTTTCACTacgctttatt
1031956 1031970 [AIBSCS], [GEA] [8]
  Fis repressor katEp Sigma38 3.0 -51.0 katE
tctatagttaGAGAGTTTTTTGACCAaaacagcggc
1813809 1813823 [AIBSCS], [GEA] [8]
  Fis activator leuQp Sigma70 -73.0 -104.0 leuQ, leuP, leuV
agtttcctgaTGGACATTTTTCCAGCaattacacct
4606498 4606512 [APIORCISFBSCS], [BCE], [GEA], [IHBCE] [30]
  Fis activator leuXp Sigma70 -75.0 -94.0 leuX
ctgtatgcaaTGCTGAAAATTTCAGCacttagcgag
4496304 4496318 [BCE]
  Fis activator lpdAp Sigma70 -29.0 -224.0 lpd
gccgtttgttGTTTAAAAATTGTTAAcaattttgta
127681 127695 [BCE], [BPP] [31], [32]
  Fis activator lysTp Sigma70 -74.0 -114.0 lysT, valT, lysW
tggtcgtgtcGTGCGAATCATAAGCAgttgagtgat
780433 780447 [IHBCE]
  Fis activator malEp Sigma70 -116.0 -161.0 malE, malF, malG
ttgcaaaaatCGTGGCGATTTTATGTGCGCatctccacat
4246571 4246590 [AIBSCS], [GEA] [8]
  Fis activator malEp Sigma70 52.0 7.0 malE, malF, malG
aaggaccataGATTATGAAAATAAAAACAGgtgcacgcat
4246404 4246423 [AIBSCS], [GEA] [8]
  Fis activator marRp Sigma70 -81.0 -108.0 marR, marA, marB
gcatcgcattGAACAAAACTTGAACCgatttagcaa
1619005 1619019 [BPP], [GEA], [SM] [33]
  Fis activator mazEp1 nd -40.5 -69.5 mazE, mazF, mazG
cgggagttagGCCGAAATTTGCTCGTatctacaatg
2911401 2911415 [BPP]