RegulonDB RegulonDB 10.9:Regulon Page
   

FNR DNA-binding transcriptional dual regulator

Synonyms: FNR, FNR-[4Fe-4S]2+ reduced, FNR-[2Fe-2S]2+ oxidized
Summary:
FNR is the primary transcriptional regulator that mediates the transition from aerobic to anaerobic growth through the regulation of hundreds of genes. Generally, this protein activates genes involved in anaerobic metabolism and represses genes involved in aerobic metabolism [8, 91]. FNR also regulates the transcription of many genes with other functions, such as acid resistance, chemotaxis, cell structure, and molecular biosynthesis, among others [8, 91]. The cellular concentration of FNR is similar under both anaerobic and aerobic growth [], but its activity is regulated directly by oxygen. Under anaerobiosis, FNR acquires a [4Fe-4S] cluster that causes a conformational change and dimerization of the protein that causes it to become activated []. Purification of [4Fe-4S]-FNR in an O2-free environment has been described [].
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
FNR Functional   [APPHINH], [HIFS] [1], [2], [3], [4]
FNR-[2Fe-2S]2+ oxidized Non-Functional Covalent Apo nd nd
FNR-[4Fe-4S]2+ reduced Functional Covalent Holo nd nd
Evolutionary Family: CRP
Sensing class: Using internal synthesized signals
Connectivity class: Global Regulator
Gene name: fnr
  Genome position: 1398774-1399526
  Length: 753 bp / 250 aa
Operon name: fnr
TU(s) encoding the TF:
Transcription unit        Promoter
fnr
fnrp


Regulon       
Regulated gene(s) aceE, aceF, ackA, acnA, acrE, acrF, adhE, aer, aldA, amtB, ansB, arcA, aspA, aspC, bcsB, bcsZ, cadC, caiA, caiB, caiC, caiD, caiE, caiF, caiT, ccmA, ccmB, ccmC, ccmD, ccmE, ccmF, ccmG, ccmH, ccp, cheB, cheR, cheY, cheZ, citC, citD, citE, citF, citG, citX, cydA, cydB, cydC, cydD, cyoA, cyoB, cyoC, cyoD, cyoE, cysG, dcuA, dcuB, dcuC, dcuR, dcuS, dmsA, dmsB, dmsC, dmsD, dpiA, dpiB, dppA,
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Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
membrane (79)
anaerobic respiration (67)
aerobic respiration (27)
electron donors (26)
electron acceptors (24)
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Regulated operon(s) ackA-pta, acrEF, adhE, aer, aldA, ansB, arcA, aspA-dcuA, aspC, bcsABZC, cadC, caiF, caiTABCDE, ccp, citCDEFXG, cydAB, cydDC, cyoABCDE, dcuB-fumB, dcuC, dcuSR, dmsABC, dpiBA, dppABCDF, emrKY, fdhF, fdnGHI, feoABC, fes-ybdZ-entF-fepE, fixABCX, fnr, fnrS, focA-pflB, frdABCD, fumAC, gadAXW, garPLRK-rnpB, gcvTHP, gdhA, glnK-amtB, glpABC, glpTQ, gltBDF, gnd, grcA, hcp-hcr-poxB-ltaE-ybjT, hemA-prfA-prmC, hlyE, hmp, hyfABCDEFGHIJR-focB, hypABCDE-fhlA, iraM, katG, malPQ, map-glnD-dapD, moaABCDE, moeAB, nac, napFDAGHBC-ccmABCDEFGH, narGHJI, narK, narXL, ndh, nfeR, nikABCDER,
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First gene in the operon(s) aceE, ackA, acnA, acrE, adhE, aer, aldA, ansB, arcA, aspA, aspC, bcsB, cadC, caiF, caiT, citC, cydA, cydD, cyoA, dcuB, dcuC, dcuS, dmsA, dpiB, dppA, emrK, fdhF, fdnG, feoA, fes, fixA, fnr, fnrS, focA, frdA, fumA, fumB, fumC, gadA, gadX, garP, gcvT, gdhA, glnD, glnK, glpA, glpT, gltB, gnd, grcA, hcp, hemA, hlyE, hmp, hyfA, hypB, idlP, iraM, katG, lpd, malP, moaA, moeA, nac, napF,
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Simple and complex regulons AcrR,FNR,Fur,SoxR
AcrR,FNR,Fur,SoxR,SoxS
AdiY,ArcA,CRP,FNR,Fis,GadE-RcsB,GadW,GadX,H-NS,RcsB,TorR
AdiY,ArcA,CRP,FNR,Fis,GadE-RcsB,GadW,GadX,H-NS,RcsB,TorR,ppGpp
AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac
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Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[FNR,-](59)
[FNR,+](79)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  FNR repressor aceEp Sigma70 nd nd aceE, aceF nd nd [BPP], [GEA], [IGI] [5], [6]
  FNR repressor aceEp2 Sigma38 nd nd aceE, aceF nd nd [BPP], [GEA], [IGI] [5], [6]
  FNR activator ackAp Sigma32 nd nd ackA nd nd [BPP], [GEA], [IGI] [6]
  FNR repressor acnAp2 Sigma70 -40.5 -90.5 acnA
tttatcaattTGGGTTGTTATCAAAtcgttacgcg
1335734 1335747 [APIORCISFBSCS], [GEA] [7]
  FNR activator acrEp Sigma70 nd nd acrE, acrF nd nd [BPP], [GEA], [IGI] [8]
  FNR activator adhEp2 Sigma38 -42.5 -230.5 adhE
tttgcaaaaaTTTGATTTGGATCACgtaatcagta
1298345 1298358 [APIORCISFBSCS], [GEA] [9]
  FNR activator aerp Sigma28 -49.5 -93.5 aer
aatcgcaaatTGCGATCTAAATCAAattaatcggt
3219163 3219176 [AIBSCS], [GEA] [10]
  FNR repressor aldAp Sigma70 -10.5 -52.5 aldA
tctctgatgaTTGATGTTAATTAACaatgtattca
1488173 1488186 [AIBSCS], [GEA] [10]
  FNR activator ansBp2 Sigma70 -41.5 -64.5 ansB
cacgttgtaaATTGTTTAACGTCAAatttcccata
3100786 3100799 [BCE], [SM]
  FNR activator arcAp1 Sigma70 -82.5 -284.5 arcA
tacaattgaaCTTGATATATGTCAAcgaagcgtag
4640584 4640597 [APIORCISFBSCS], [GEA] [11]
  FNR repressor arcAp3 Sigma70 -55.5 -284.5 arcA
tacaattgaaCTTGATATATGTCAAcgaagcgtag
4640584 4640597 [APIORCISFBSCS], [GEA] [11], [12]
  FNR activator aspAp Sigma70 -40.5 -145.5 aspA, dcuA
cgacacttaaAGTGATCCAGATTACggtagaaatc
4368466 4368479 [APIORCISFBSCS], [GEA] [13]
  FNR activator aspCp nd nd nd aspC nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor aspCp nd nd nd aspC nd nd [BPP], [GEA], [IGI] [12]
  FNR activator bcsBp Sigma70 nd nd bcsB, bcsZ nd nd [BPP], [GEA], [IGI] [8]
  FNR activator cadCp Sigma70 -156.5 -185.5 cadC
gatgatgaatTTTGATGGTAAGGAAtattacttct
4362113 4362126 [AIBSCS], [GEA] [10]
  FNR activator caiFp Sigma70 -55.5 -137.5 caiF
atcgatatttTTGATGACATAAGCAggatttagct
34156 34169 [BCE], [GEA] [14]
  FNR activator caiTp Sigma70 -90.5 -196.5 caiT, caiA, caiB, caiC, caiD, caiE
caaactgattATTAATCAAAATTAAcgaaaaaacg
42121 42134 [AIBSCS], [GEA] [8], [10]
  FNR activator caiTp Sigma70 -41.5 -147.5 caiT, caiA, caiB, caiC, caiD, caiE
gaaacaaaaaTGTGATACCAATCACagaatacagc
42072 42085 [AIBSCS], [GEA] [8], [10]
  FNR repressor citCp2 nd 11.5 -172.5 citC, citD, citE, citF, citX, citG
actaactctaTGTGAAATAAATCAAaatttcacgc
652022 652035 [AIBSCS], [AIBSCS] [15]
  FNR repressor cydAp1 Sigma70 -53.5 -341.5 cydA, cydB
tttgtaggaaTTGATATTTATCAATgtataagtct
771110 771123 [AIBSCS], [BPP], [GEA] [8], [16], [17], [18], [19], [20], [21]
  FNR repressor cydAp1 Sigma70 -1.5 -289.5 cydA, cydB
aagagataaaTTGTTCTCGATCAAAttggctgaaa
771162 771175 [APIORCISFBSCS], [BPP], [GEA] [8], [16], [17], [19], [20], [21]
  FNR activator cydAp2 Sigma70 -167.5 -341.5 cydA, cydB
tttgtaggaaTTGATATTTATCAATgtataagtct
771110 771123 [AIBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp2 Sigma70 -115.5 -289.5 cydA, cydB
aagagataaaTTGTTCTCGATCAAAttggctgaaa
771162 771175 [APIORCISFBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp3 Sigma70 -85.5 -341.5 cydA, cydB
tttgtaggaaTTGATATTTATCAATgtataagtct
771110 771123 [AIBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp3 Sigma70 -33.5 -289.5 cydA, cydB
aagagataaaTTGTTCTCGATCAAAttggctgaaa
771162 771175 [APIORCISFBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp4 Sigma70 -96.5 -341.5 cydA, cydB
tttgtaggaaTTGATATTTATCAATgtataagtct
771110 771123 [AIBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp4 Sigma70 -44.5 -289.5 cydA, cydB
aagagataaaTTGTTCTCGATCAAAttggctgaaa
771162 771175 [APIORCISFBSCS], [BPP], [GEA] [8], [19], [21]
  FNR activator cydDp Sigma70 -90.5 -159.5 cydD, cydC
catggcagcaCTTGATGCGGAACGCtacctcgatg
931115 931128 [APIORCISFBSCS], [GEA] [22]
  FNR repressor cyoAp Sigma70 -192.5 -235.5 cyoA, cyoB, cyoC, cyoD, cyoE
tttgttaaatAATTGTTTTATTTCAcattggttat
451839 451852 [AIBSCS], [GEA] [8], [10], [12], [13], [16]
  FNR activator dcuBp Sigma70 -45.5 -65.5 dcuB, fumB
tctgaaaacaGTTCATACAAAACAGaacgtgactg
4348803 4348816 [APIORCISFBSCS], [GEA] [23]
  FNR activator dcuCp nd -115.5 -230.5 dcuC
agctaacaccATTGCAATTAACAAAtttgcatcaa
656192 656205 [APIORCISFBSCS], [GEA] [24]
  FNR activator dcuCp nd -63.5 -178.5 dcuC
cacattattaTGTGATAATTGCCAAccgctaaata
656140 656153 [APIORCISFBSCS], [GEA] [24]
  FNR activator dcuCp nd -33.5 -148.5 dcuC
aaatatgcgtTTTGTTATCTATGTAtaaaaacagc
656110 656123 [APIORCISFBSCS], [GEA] [24]
  FNR activator dcuSp Sigma70 nd nd dcuS, dcuR nd nd [BPP], [GEA], [IGI] [8]
  FNR activator dmsAp1 Sigma70 -41.5 -177.5 dmsA, dmsB, dmsC
ttgtctccctTTGATACCGAACAATaattactcct
940775 940788 [BCE], [BPP], [GEA], [SM] [25], [26], [27]
  FNR repressor dpiBp nd 45.5 -206.5 dpiB, dpiA
gcgtgaaattTTGATTTATTTCACAtagagttagt
652022 652035 [AIBSCS] [15]
  FNR repressor dppAp Sigma70 -162.5 -327.5 dppA, dppB, dppC, dppD, dppF
atcaccaaatGTTGCTAAATATTAAgctgattgtt
3708026 3708039 [AIBSCS], [GEA] [10]
  FNR activator emrKp nd nd nd emrK, emrY nd nd [BPP], [GEA], [IGI] [8]
  FNR activator fdhFp Sigma54 nd nd fdhF nd nd [BPP], [GEA], [IGI] [8]
  FNR activator fdnGp Sigma70 -97.5 -126.5 fdnG, fdnH, fdnI
tctaccgctaTTGAGGTAGGTCAATttgcgaaggc
1547268 1547281 [APIORCISFBSCS], [GEA], [SM] [28]
  FNR repressor fdnGp Sigma70 -97.5 -126.5 fdnG, fdnH, fdnI
tctaccgctaTTGAGGTAGGTCAATttgcgaaggc
1547268 1547281 [APIORCISFBSCS], [GEA], [SM] [28]
  FNR activator fdnGp Sigma70 -42.5 -71.5 fdnG, fdnH, fdnI
gatgttctttTTGATTTCGCGCAAAaagattcaga
1547323 1547336 [APIORCISFBSCS], [GEA], [SM] [28]
  FNR activator feoAp Sigma70 -90.5 -196.5 feoA, feoB, feoC
gctgcgatatAACCTTGAGCCACATCAACATTGagtcagatta
3539956 3539978 [APIORCISFBSCS], [GEA] [29]
  FNR activator fesp Sigma70 -143.5 -193.5 fes, ybdZ, entF, fepE
aactgtcgggCATGGTCGTCATCAAcacgacgcat
612537 612550 [AIBSCS], [GEA] [10]
  FNR activator fixAp Sigma70 -197.5 -275.5 fixA, fixB, fixC, fixX
cgttttttcgTTAATTTTGATTAATaatcagtttg
42121 42134 [AIBSCS], [GEA] [8], [10]
  FNR activator fnrSp Sigma70 -42.5 -42.5 fnrS
gccgcaaagtTTGAGCGAAGTCAATaaactctcta
1409080 1409093 [APIORCISFBSCS], [BPP], [GEA] [30]
  FNR repressor fnrp Sigma70 -0.5 -26.5 fnr
agatgttaaaATTGACAAATATCAAttacggcttg
1399546 1399559 [APIORCISFBSCS], [BCE], [BPP], [GEA] [3]
  FNR activator focAp1 Sigma70 -40.5 -67.5 focA, pflB
ccaggcgagaTATGATCTATATCAAtttctcatct
954527 954540 [APIORCISFBSCS], [BCE], [GEA], [SM] [31]
  FNR activator focAp3 Sigma70 -58.5 -406.5 focA, pflB
agcattctggGCAAAATAAAATCAAatagcctacg
954866 954879 [BCE], [GEA], [SM] [31]
  FNR activator frdAp Sigma70 -45.5 -139.5 frdA, frdB, frdC, frdD
cactaaaaaaATCGATCTCGTCAAAtttcagactt
4382451 4382464 [BCE], [GEA] [6], [32], [33], [34]
  FNR activator frdAp2 Sigma38 -45.5 -139.5 frdA, frdB, frdC, frdD
cactaaaaaaATCGATCTCGTCAAAtttcagactt
4382451 4382464 [BCE], [GEA] [6], [32], [33], [34]
  FNR repressor fumAp Sigma70 nd nd fumA, fumC nd nd [BPP], [GEA], [IGI] [35]
  FNR activator fumBp Sigma70 -114.5 -136.5 fumB
ttctgccgggGTTGATTGGTGTGAGcgtatcgtgc
4347456 4347469 [BCE], [GEA] [13], [36], [37]
  FNR activator fumBp Sigma70 -61.5 -83.5 fumB
gccgcgatgtACGGGTTCTTATAAAtgcactttgc
4347403 4347416 [BCE], [GEA] [36], [37]
  FNR activator fumBp Sigma70 -57.5 -79.5 fumB
cgatgtacggGTTCTTATAAATGCActttgcgtgc
4347399 4347412 [BCE], [GEA] [36], [37]
  FNR repressor fumCp Sigma38 nd nd fumC nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor gadAp Sigma70 11.5 -16.5 gadA, gadX
tttattgcctTCAAATAAATTTAAGgagttcgaaa
3667590 3667603 [AIBSCS], [GEA] [10]
  FNR repressor gadAp2 Sigma38 11.5 -16.5 gadA, gadX
tttattgcctTCAAATAAATTTAAGgagttcgaaa
3667590 3667603 [AIBSCS], [GEA] [10]
  FNR repressor gadXp Sigma38 -159.5 -188.5 gadX, gadW
aaagggattaTTTGCTTACTATTAAtttccctgtg
3665992 3666005 [AIBSCS], [GEA] [10]
  FNR activator garPp Sigma70 nd nd garP, garL, garR, garK, rnpB nd nd [BPP], [GEA], [IGI] [10]
  FNR activator gcvTp Sigma70 nd nd gcvT, gcvH, gcvP nd nd [BPP], [GEA], [IGI] [8]
  FNR activator gdhAp1 Sigma70 nd nd gdhA nd nd [BPP], [GEA], [IGI] [12]
  FNR activator glnDp nd nd nd glnD nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor glnDp nd nd nd glnD nd nd [BPP], [GEA], [IGI] [12]
  FNR activator glnKp Sigma54 nd nd glnK, amtB nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor glnKp Sigma54 nd nd glnK, amtB nd nd [BPP], [GEA], [IGI] [12]
  FNR activator glpABCp Sigma70 -40.5 -104.5 glpA, glpB, glpC
gttcaaaatgACGCATGAAATCACGtttcactttc
2352536 2352549 [AIBSCS], [GEA] [38], [39]
  FNR activator glpABCp Sigma70 -0.5 -64.5 glpA, glpB, glpC
atgagcgaatATGCGCGAAATCAAAcaattcatgt
2352576 2352589 [APIORCISFBSCS], [GEA] [38], [39]
  FNR activator glpTQp Sigma70 -131.5 -208.5 glpT, glpQ
acatgaattgTTTGATTTCGCGCATattcgctcat
2352576 2352589 [APIORCISFBSCS], [GEA] [40]
  FNR activator glpTQp Sigma70 -91.5 -168.5 glpT, glpQ
gaaagtgaaaCGTGATTTCATGCGTcattttgaac
2352536 2352549 [AIBSCS], [GEA] [40]
  FNR repressor gltBp Sigma70 -26.5 -242.5 gltB, gltD, gltF
agcttgccatTTGACCTGTATCAGCtttcccgata
3354476 3354489 [AIBSCS], [GEA] [10], [12]
  FNR repressor gltBp2 Sigma38 -26.5 -242.5 gltB, gltD, gltF
agcttgccatTTGACCTGTATCAGCtttcccgata
3354476 3354489 [AIBSCS], [GEA] [10], [12]
  FNR repressor gndp Sigma70 nd nd gnd nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor grcAp1 Sigma70 -93.5 -167.5 grcA
acccgcataaGTTGATGTAAAACAAtaaaatccat
2716610 2716623 [BPP], [GEA], [SM] [12], [41], [42], [43]
  FNR activator grcAp1 Sigma70 -40.5 -114.5 grcA
tgtggtttttATTGATTTAAATCAAagattcaagg
2716557 2716570 [BPP], [GEA], [SM] [6], [41], [42], [43]
  FNR repressor grcAp1 Sigma70 -40.5 -114.5 grcA
tgtggtttttATTGATTTAAATCAAagattcaagg
2716557 2716570 [BPP], [GEA], [SM] [6], [41], [42], [43]
  FNR activator hcpp nd -72.5 -103.5 hcp, hcr, poxB
tgccgccaaaATTGCGCTAAATCAAtctcccttaa
913911 913924 [APIORCISFBSCS], [BPP], [GEA], [SM] [44], [45]
  FNR repressor hemAp1 Sigma70 -24.5 -62.5 hemA, prfA, prmC
ctctcttttaTTGATCTTACGCATCctgtatgatg
1263645 1263658 [BPP], [GEA] [46], [47]
  FNR activator hlyEp nd -61.5 -133.5 hlyE
ttaaacattgTTTGATATTTATCATattaatagaa
1230521 1230534 [BPP], [GEA] [48], [49]
  FNR repressor hmpp Sigma38 5.5 -33.5 hmp
taagatgcatTTGAGATACATCAATtaagatgcaa
2685795 2685808 [APIORCISFBSCS], [BPP], [GEA], [SM] [50], [51], [52]
  FNR repressor hyfAp Sigma54 -105.5 -135.5 hyfA, hyfB, hyfC, hyfD, hyfE, hyfF, hyfG, hyfH, hyfI, hyfJ, hyfR, focB
aatccattttTTGCTGAACGTTAATgaccatcatt
2601059 2601072 [APIORCISFBSCS], [GEA] [53]
  FNR activator hypBp nd -149.5 -311.5 hypB, hypC, hypD, hypE, fhlA
ggcactggaaTTGATCGAACAGCAGgccgcaaaac
2850683 2850696 [BPP], [GEA] [54]
  FNR activator hypBp nd -43.5 -205.5 hypB, hypC, hypD, hypE, fhlA
gccttttgttTTGATCTGGTTTGCCgcggcagcgt
2850789 2850802 [BCE], [BPP], [GEA] [54]
  FNR activator idlPp Sigma38 nd nd idlP, iraD nd nd [BPP], [GEA], [IGI] [10]
  FNR activator iraDp2 Sigma70 nd nd idlP, iraD nd nd [BPP], [GEA], [IGI] [10]
  FNR activator iraMp nd -70.5 -157.5 iraM
aaaatctcatTTTGTTTAACATCCAttgagattcc
1212154 1212167 [AIBSCS] [55]
  FNR activator katGp Sigma70 -112.5 -135.5 katG
atcaaaaaagCTTAATTAAGATCAAtttgatctac
4133693 4133706 [AIBSCS], [GEA] [10]
  FNR activator katGp Sigma70 -96.5 -119.5 katG
taagatcaatTTGATCTACATCTCTttaaccaaca
4133709 4133722 [EME], [AIBSCS], [AIBSPD], [CCE], [GEA] [10], [56]
  FNR activator lpdAp Sigma70 nd nd lpd nd nd [BPP], [GEA], [IGI] [8], [12]
  FNR repressor lpdAp Sigma70 nd nd lpd nd nd [BPP], [GEA], [IGI] [8], [12]
  FNR activator malPp Sigma70 -127.5 -164.5 malP, malQ
attgcattgaTTTGATGCTAATCCTgtggtttgca
3552631 3552644 [AIBSCS], [GEA] [10]
  FNR activator moaAp1 nd -39.5 -256.5 moaA, moaB, moaC, moaD, moaE
tgcctccctgATGATGTATATCAAAgtaaaaccgc
816781 816794 [APIORCISFBSCS], [GEA] [57], [58]
  FNR repressor moeAp Sigma70 34.5 4.5 moeA, moeB
gcaggagtgtTTTCATGGAATTTACcaccggattg
866354 866367 [BPP], [GEA] [59]
  FNR repressor nacp Sigma54 nd nd nac nd nd [BPP], [GEA], [IGI] [12]
  FNR activator napFp1 Sigma70 -64.5 -141.5 napF, napD, napA, napG, napH, napB, napC, ccmA, ccmB, ccmC, ccmD, ccmE, ccmF, ccmG, ccmH
ccgccactctTTTGATCCTGCTACAggttttaccc
2303632 2303645 [APIORCISFBSCS], [GEA], [SM] [60], [61]
  FNR activator narGp Sigma70 -41.5 -98.5 narG, narH, narJ, narI
cccatcactcTTGATCGTTATCAATtcccacgctg
1279759 1279772 [APIORCISFBSCS], [BPP], [GEA], [SM] [26], [27]
  FNR activator narKp1 Sigma70 -79.5 -104.5 narK
actatgggtaATGATAAATATCAATgatagataaa
1277846 1277859 [BCE], [GEA], [SM] [62]
  FNR activator narKp1 Sigma70 -41.5 -66.5 narK
atcttatcgtTTGATTTACATCAAAttgcctttag
1277884 1277897 [EME], [AIBSPD], [BCE], [BPP], [CCE], [SM] [27], [56]
  FNR repressor narXp Sigma70 -106.5 -265.5 narX, narL
caatttgatgTAAATCAAACGATAAgataacttta
1277877 1277890 [AIBSPD], [APIORCISFBSCS], [BCE], [CCE] [4], [63]
  FNR repressor narXp Sigma70 -75.0 -234.0 narX, narL
ttatctatcaTTGATATTTATCATTacccatagtg
1277845 1277858 [APIORCISFBSCS], [BPP] [4]
  FNR repressor narXp Sigma70 107.5 -52.5 narX, narL
gccattccagAATGTATCGTCACATtcattaaggt
1277664 1277677 [APIORCISFBSCS], [BCE] [4]
  FNR repressor ndhp Sigma70 -94.5 -187.5 ndh
actctgttttTTGATCTCACCCGGTaaagtcgcct
1165891 1165904 [BCE], [GEA], [SM] [8], [12], [64]
  FNR repressor ndhp Sigma70 -50.5 -143.5 ndh
gcaacaaaacTTGATTAACATCAATtttggtatga
1165935 1165948 [BCE], [GEA], [SM] [8], [12], [64]
  FNR activator nikAp1 nd -40.5 -79.5 nikA, nikB, nikC, nikD, nikE, nikR
tgcccatctaTTGATCCAGAACAGGtaatcagtat
3613581 3613595 [APIORCISFBSCS], [GEA], [SM] [65], [66]
  FNR activator nirBp Sigma70 -41.5 -65.5 nirB, nirD, nirC, cysG
aaaggtgaatTTGATTTACATCAATaagcggggtt
3493939 3493952 [APIORCISFBSCS], [BPP], [GEA], [SM] [1], [34], [67], [68], [69]
  FNR repressor norVp Sigma54 -140.5 -177.5 norV, norW
aaactcatctTTGCCTCACTGTCAAtttgactata
2832292 2832305 [APIORCISFBSCS], [GEA] [70]
  FNR activator nrdDp Sigma70 -64.5 -242.5 nrdD, nrdG
tgctttttacTTTGAGCTACATCAAaaaaagctca
4462896 4462909 [APIORCISFBSCS], [BPP], [GEA], [SM] [71], [72]
  FNR activator nrdDp Sigma70 -33.5 -211.5 nrdD, nrdG
ctcaaacatcCTTGATGCAAAGCACtatatataga
4462865 4462878 [APIORCISFBSCS], [BPP], [GEA], [SM] [71], [72]
  FNR activator nrfAp Sigma70 -41.5 -134.5 nrfA, nrfB, nrfC, nrfD, nrfE, nrfF, nrfG
gcacttacaaTTGATTAAAGACAACattcacagtg
4287623 4287636 [BCE], [BPP], [GEA] [73], [74]
  FNR repressor nuoAp2 Sigma70 -40.5 -130.5 nuoA, nuoB, nuoC, nuoE, nuoF, nuoG, nuoH, nuoI, nuoJ, nuoK, nuoL, nuoM, nuoN
agaaaggagtAAAAAACCACATCAAttagctgtat
2405196 2405209 [BCE], [GEA], [SM] [8], [12]
  FNR repressor ompWp nd -126.5 -155.5 ompW
tatttaaaaaTTGATTTAAATCACAttaaccagga
1313858 1313871 [AIBSCS], [BPP], [GEA] [75]
  FNR activator ompWp nd -81.5 -110.5 ompW
aacttctaaaTTAATCCAGATCAATaaagggtgaa
1313903 1313916 [AIBSCS], [APIORCISFBSCS], [BPP], [GEA] [75]
  FNR repressor ompXp2 nd nd nd ompX nd nd [BPP], [GEA], [IGI] [10]
  FNR activator pdhRp Sigma70 -50.5 -108.5 pdhR, aceE, aceF, lpd
gcacagtttcATGATTTCAATCAAAacctgtatgg
121977 121990 [AIBSCS], [BCE], [GEA] [5], [8], [10]
  FNR repressor pdhRp Sigma70 -50.5 -108.5 pdhR, aceE, aceF, lpd
gcacagtttcATGATTTCAATCAAAacctgtatgg
121977 121990 [AIBSCS], [BCE], [GEA] [5], [8], [10]
  FNR activator pdhRp2 Sigma38 -50.5 -108.5 pdhR, aceE, aceF, lpd
gcacagtttcATGATTTCAATCAAAacctgtatgg
121977 121990 [AIBSCS], [BCE], [GEA] [5], [8], [10]
  FNR repressor pdhRp2 Sigma38 -50.5 -108.5 pdhR, aceE, aceF, lpd
gcacagtttcATGATTTCAATCAAAacctgtatgg
121977 121990 [AIBSCS], [BCE], [GEA] [5], [8], [10]
  FNR activator pepTp nd nd nd pepT nd nd [BPP], [GEA], [IGI] [10]
  FNR activator pitAp nd nd nd pitA nd nd [BPP], [GEA], [IGI] [10]
  FNR activator pstSp Sigma70 nd nd pstS, pstC, pstA, pstB, phoU nd nd [BPP], [GEA], [IGI] [8]
  FNR activator pstSp2 Sigma38 nd nd pstS, pstC, pstA, pstB, phoU nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor purMp Sigma70 -192.5 -236.5 purM, purN
attcttttcgTTGACTTTAGTCAAAatgataacgg
2620954 2620967 [AIBSCS], [APIORCISFBSCS], [GEA], [SM] [8], [76]
  FNR repressor puuAp Sigma38 29.0 -32.0 puuA, ymjE, puuP
tattttacgcTTTGATAACGAGCGGaaaacaaacc
1360933 1360946 [AIBSCS], [GEA] [55]
  FNR activator ravAp Sigma38 -201.5 -236.5 ravA, viaA
gcgggcaatgATTGCTTATTATCAGtgctcataga
3931323 3931336 [APIORCISFBSCS], [BPP], [GEA], [SM] [77]
  FNR activator ravAp Sigma38 -71.5 -106.5 ravA, viaA
atgcggccacATTAACCTGGCTCAAagaaaaatac
3931193 3931206 [APIORCISFBSCS], [BPP], [GEA], [SM] [77]
  FNR repressor rplMp nd nd nd rplM, rpsI nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor rplTp nd nd nd rplT, pheM nd nd [BPP], [GEA], [IGI] [8]
  FNR activator rpsJp Sigma70 nd nd rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor rpsPp Sigma70 nd nd rpsP, rimM, trmD, rplS nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor sdhCp Sigma70 nd nd sdhC, sdhD, sdhA, sdhB, sucA, sucB, sucC, sucD, sdhX nd nd [BPP], [GEA], [IGI] [12], [78]
  FNR repressor sodAp Sigma70 -37.5 -88.5 sodA
aagtacggcaTTGATAATCATTTTCaatatcattt
4100715 4100728 [BCE], [GEA] [12], [79], [80]
  FNR repressor soxRp Sigma70 nd nd soxR nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor soxSp Sigma70 nd nd soxS nd nd [BPP], [GEA], [IGI] [12]
  FNR activator ssuEp Sigma70 nd nd ssuE, ssuA, ssuD, ssuC, ssuB nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor sucAp Sigma38 nd nd sucA, sucB, sucC, sucD nd nd [BPP], [GEA], [IGI] [81]
  FNR activator tarp Sigma28 nd nd tar, tap, cheR, cheB, cheY, cheZ nd nd [BPP], [GEA], [IGI] [10]
  FNR activator tdcAp nd -148.5 -176.5 tdcA, tdcB, tdcC, tdcD, tdcE, tdcF, tdcG
cgtcatttttTTTGACAAAAATCAGggtttatgct
3267235 3267248 [AIBSCS], [GEA] [10]
  FNR activator tdcAp nd -105.5 -133.5 tdcA, tdcB, tdcC, tdcD, tdcE, tdcF, tdcG
tactttaactTGTTGATATTTAAAGgtatttaatt
3267192 3267205 [AIBSCS], [GEA] [10]
  FNR repressor tpxp Sigma70 -18.5 -51.5 tpx
ttgctgtgttATTGACAGTTAGCATaaactaggtg
1388856 1388869 [APIORCISFBSCS], [GEA] [82]
  FNR repressor ubiCp Sigma70 -0.5 -63.5 ubiC, ubiA
atcacttaatTTGCTTTACATCTCCcgtaaacact
4252436 4252449 [APIORCISFBSCS], [GEA] [83]
  FNR activator uppp Sigma70 -61.5 -98.5 upp, uraA
ttatctcaaaCCGTTATCATTTTGActaaagtcaa
2620964 2620977 [AIBSCS], [GEA] [10]
  FNR activator uxaCp Sigma70 nd nd uxaC, uxaA nd nd [BPP], [GEA], [IGI] [10]
  FNR activator xdhAp nd nd nd xdhA, xdhB, xdhC nd nd [BPP], [GEA], [IGI] [8]
  FNR activator ybdNp Sigma70 -303.5 -420.5 ybdN
atcagcagggGTTGATGATATTCAAatggaaatag
636983 636996 [AIBSCS] [55]
  FNR activator ybdNp Sigma70 -26.5 -143.5 ybdN
aatgagagttTTTGATATATAACTAcagacagcta
636706 636719 [AIBSCS] [55]
  FNR repressor ychOp Sigma70 nd nd ychO nd nd [BPP], [GEA], [IGI] [10]
  FNR activator ydeJp Sigma70 -404.5 -489.5 ydeJ
gtcctctcctTTGTGAGAAATCAAAttaccgcgta
1624277 1624290 [AIBSCS] [55]
  FNR activator ydhYp Sigma38 -42.5 -207.5 ydhY, ydhV, ydhW, ydhX, ydhU, ydhT
tgtaattttaATTGATAACGATCAAtgttaagggc
1754678 1754691 [APIORCISFBSCS], [BPP], [GEA], [SM] [84]
  FNR activator yecRp nd nd nd yecR nd nd [BPP], [GEA], [IGI] [10]
  FNR repressor yeiLp Sigma38 -28.5 -93.5 yeiL
gggccgatgaTTGAATCTTAACAACagcgtacgta