RegulonDB RegulonDB 10.9:Regulon Page
   

CRP DNA-binding transcriptional dual regulator

Synonyms: CRP-cAMP, CRP
Summary:
CRP appears to interact with the Sxy protein to regulate some genes related to DNA uptake (natural competence). The residues Q194 and L196, located in the named Sxy Interacting Region (SIR) and close to the DNA-binding region in CRP, appear to be involved in the CRP-Sxy interaction [249]. The CRP-Sxy complex recognized a DNA-binding site that has an asymmetric organization: it has two distinct half sites, one of which is similar to the canonical CRP DNA-binding site, but the other half site is less conserved [249]. In E. coli [] and in some other bacteria, the putative regulon CRP-Sxy has been identified through microarray analysis [126].


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
CRP Non-Functional   Apo [IPI] [1]
CRP-cAMP Functional Allosteric Holo [APPH], [APPP], [HIFS], [IEP], [IHBCE], [IMP], [IPI] [1], [2], [3], [4], [5], [6], [7], [8], [9], [10]
Evolutionary Family: CRP
Sensing class: Using internal synthesized signals
Connectivity class: Global Regulator
Gene name: crp
  Genome position: 3486120-3486752
  Length: 633 bp / 210 aa
Operon name: crp
TU(s) encoding the TF:
Transcription unit        Promoter
crp
crpp1
crp
crpp2
crp
crpp3


Regulon       
Regulated gene(s) aaeA, aaeB, aaeR, aaeX, aceA, aceB, aceE, aceF, aceK, acnA, acnB, acs, actP, aer, agaA, agaV, agaW, agp, aldA, aldB, ampD, ampE, ansB, araA, araB, araC, araD, araE, araF, araG, araH, araJ, arfB, argG, aroA, ascB, ascF, aspA, azuC, bglB, bglF, bglG, bhsA, btsT, caiA, caiB, caiC, caiD, caiE, caiF, caiT, cas1, cas2, cas3, casA, casB, casC, casD, casE, cdd, chbA, chbB, chbC, chbF, chbG,
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Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
membrane (102)
Transcription related (62)
activator (39)
Porters (Uni-, Sym- and Antiporters) (39)
operon (38)
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Regulated operon(s) aaeR, aaeXAB, aceBAK, acnB, acs-yjcH-actP, aer, agp, aldA, aldB, ampDE, ansB, araBAD, araC, araE-ygeA, araFGH, araJ, argG, ascFB, aspA-dcuA, azuC, bglGFB, bhsA, btsT, caiF, caiTABCDE, cas3, casABCDE12, cdd, chbBCARFG, chiPQ, cirA, citCDEFXG, comR, cpdB, crp, csgDEFG, csiE, cspD, cspE, csrC, cstA, cyaA, cyaR, cyoABCDE, cytR, dadAX, dctA, dcuB-fumB, dcuSR, deoCABD, dgoRKADT, dpiBA, dsdXA, dusB-fis, ebgAC, entCEBAH, epd-pgk-fbaA, exuR, exuT, fadD-sroD, fadH, fadL, feaB, feaR, fecABCDE,
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First gene in the operon(s) aaeR, aaeX, aceB, acnA, acnB, acs, aer, agp, aldA, aldB, ampD, ansB, araB, araC, araE, araF, araJ, argG, ascF, aspA, azuC, bglG, btsT, caiF, caiT, cas3, casA, cdd, chbB, chiP, cirA, citC, cpdB, crp, csgD, glaH, csiE, cspD, cspE, csrC, cstA, cyaA, cyaR, cyoA, cytR, dadA, dctA, dcuB, dcuR, deoC, dgoR, dpiB, dsdA, dsdX, dusB, ebgA, entC, epd, exuR, exuT, fadD, fadH, fadL, feaB, feaR,
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Simple and complex regulons AcrR,CRP,CpxR,Cra,Fis,MarA,MarR,Rob,SoxS
AcrR,CRP,FliZ,Fur,H-NS,HdfR,IHF,LrhA,MatA,OmpR,QseB,RcsAB,YjjQ
AdiY,ArcA,CRP,FNR,Fis,GadE-RcsB,GadW,GadX,H-NS,RcsB,TorR
AdiY,ArcA,CRP,FNR,Fis,GadE-RcsB,GadW,GadX,H-NS,RcsB,TorR,ppGpp
AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac
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Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[CRP-Sxy,+](230)
[CRP,-](85)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  CRP-cAMP repressor aaeRp nd -2.5 -26.5 aaeR
gttatctataTTATGTGATCTAAATCACTTTTAagtcagagtg
3389483 3389505 [APIORCISFBSCS], [GEA], [AIBSCS], [APIORCISFBSCS], [GEA] [11]
  CRP-cAMP activator aaeXp nd -63.5 -156.5 aaeX, aaeA, aaeB
cactctgactTAAAAGTGATTTAGATCACATAAtatagataac
3389483 3389505 [AIBSCS], [APIORCISFBSCS], [GEA] [11], [12]
  CRP-cAMP repressor aceBp Sigma70 -30.5 -106.5 aceB, aceA, aceK
ttaaaatggaAATTGTTTTTGATTTTGCATTTTaaatgagtag
4215361 4215382 [AIBSCS], [GEA] [9]
  CRP-cAMP activator acnAp2 Sigma70 -40.5 -90.5 acnA
ctcttttatcAATTTGGGTTGTTATCAAATCGTtacgcgatgt
1335730 1335751 [APIORCISFBSCS], [GEA] [13]
  CRP-cAMP activator acnBp Sigma70 -37.5 -133.5 acnB
tatgttgcttTTTTGTAAACAGATTAACACCTCgtcaaaatcc
131471 131492 [APIORCISFBSCS], [GEA] [13]
  CRP-cAMP activator acsp Sigma38 -122.5 -142.5 acs, yjcH, actP
attaatcaacTTTTGTTGCTGACCTTCAAAAATtaccctgccg
4287503 4287524 [AIBSCS], [BPP], [GEA], [SM] [14], [15], [16]
  CRP-cAMP activator acsp Sigma38 -69.5 -89.5 acs, yjcH, actP
caattctactTTTGCGTGATCTGTCGCCCAAATactaaacaaa
4287450 4287471 [AIBSCS], [BPP], [GEA], [SM] [14], [15], [16]
  CRP-cAMP activator acsp2 Sigma70 -122.5 -142.5 acs, yjcH, actP
attaatcaacTTTTGTTGCTGACCTTCAAAAATtaccctgccg
4287503 4287524 [AIBSCS], [BPP], [GEA], [SM] [14], [15], [16]
  CRP-cAMP activator acsp2 Sigma70 -69.5 -89.5 acs, yjcH, actP
caattctactTTTGCGTGATCTGTCGCCCAAATactaaacaaa
4287450 4287471 [AIBSCS], [BPP], [GEA], [SM] [14], [15], [16]
  CRP-cAMP activator aerp Sigma28 -49.5 -93.5 aer
tttaaatcgcAAATTGCGATCTAAATCAAATTAatcggttaaa
3219159 3219180 [AIBSCS], [BCE], [BPP], [GEA], [SM] [17]
  CRP-cAMP activator agpp nd -232.5 -258.5 agp
tgctaaaaacCATTGTTATTAGTCTCACACTTTtttattggta
1065316 1065338 [AIBSCS], [GEA] [18]
  CRP-cAMP activator aldAp Sigma70 -59.5 -101.5 aldA
ttacacttgtTTTTATGAAGCCCTTCACAGAATtgtcctttca
1488120 1488141 [BCE], [GEA] [19]
  CRP-cAMP activator aldBp Sigma38 -60.5 -84.5 aldB
ccttgcccgtAAATTCGTGATAGCTGTCGTAAAgctgttaccg
3756585 3756606 [AIBSCS], [BPP] [20]
  CRP-cAMP repressor ampD nd 6.5 -24.5 ampD, ampE
gctactctgaACCGGGTATTAGCACCACATATAaggagatcct
118698 118720 [APIORCISFBSCS], [GEA], [AIBSCS], [GEA] [11]
  CRP-cAMP activator ansBp2 Sigma70 -91.5 -114.5 ansB
ttaattcttcGTTTTGTTACCTGCCTCTAACTTtgtagatctc
3100832 3100853 [BCE], [SM]
  CRP-cAMP activator araBp Sigma70 -93.5 -120.5 araB, araA, araD
gtccacattgATTATTTGCACGGCGTCACACTTtgctatgcca
70158 70179 [APIORCISFBSCS], [BPP], [GEA], [SM] [21], [22], [23]
  CRP-cAMP activator araCp Sigma70 -54.5 -218.5 araC
tggcatagcaAAGTGTGACGCCGTGCAAATAATcaatgtggac
70158 70179 [APIORCISFBSCS], [BPP], [GEA], [SM]
  CRP-cAMP activator araEp Sigma70 -94.5 -120.5 araE, ygeA
cttaatttgaAAATTGGAATATCCATCACATAAcgacatgtcg
2982292 2982313 [AIBSCS], [BPP] [24]
  CRP-cAMP activator araFp Sigma70 -42.5 -152.5 araF, araG, araH
ctgtaattctGCGATGTGATATTGCTCTCCTATggagaattaa
1986270 1986291 [APIORCISFBSCS], [BPP], [GEA], [SM] [25], [26], [27]
  CRP-cAMP activator araFp3 Sigma38 -42.5 -152.5 araF, araG, araH
ctgtaattctGCGATGTGATATTGCTCTCCTATggagaattaa
1986270 1986291 [APIORCISFBSCS], [BPP], [GEA], [SM] [25], [26], [27]
  CRP-cAMP activator araJp Sigma70 -90.5 -138.5 araJ
acagcaaactGGAAAGTACGTTTGCAGTGAAATaactattcag
412609 412630 [APIORCISFBSCS], [BPP] [26]
  CRP-cAMP repressor araJp Sigma70 44.5 -4.5 araJ
gccgttctggTGGTTGTGATGGTGGTATGAAAAaagtcatttt
412475 412497 [APIORCISFBSCS], [BPP] [26]
  CRP-cAMP activator argGp Sigma70 -167.5 -242.5 argG
ctgcaggcatTATAGTGATCCACGCCACATTTTgtcaacgttt
3318384 3318405 [BPP], [GEA], [SM] [28]
  CRP-cAMP activator ascFp Sigma70 -71.5 -166.5 ascF, ascB
ggaaaaatatTCAGGTGACCGGTTTCACAAATAtaaaaaatga
2839347 2839368 [BPP], [ICWHO] [29]
  CRP-cAMP activator aspAp Sigma70 -90.5 -195.5 aspA, dcuA
agtaatcccaAAGCGGTGATCTATTTCACAAATtaataattaa
4368512 4368534 [AIBSCS], [APIORCISFBSCS], [GEA] [3], [12], [30], [31]
  CRP-cAMP repressor azuCp Sigma70 -48.5 -90.5 azuC
taaaggggtaTTTATGTGATTTGTATCACATAAagattgattt
1988039 1988060 [APIORCISFBSCS], [GEA] [32]
  CRP-cAMP repressor azuCp Sigma70 -18.5 -60.5 azuC
taaagattgaTTTTTGTGATGGTTGTCATATTAtaagcgcaaa
1988009 1988030 [APIORCISFBSCS], [GEA] [32]
  CRP-cAMP activator bglGp nd -61.5 -191.5 bglG, bglF, bglB
acaaagttaaTAACTGCGAGCATGGTCATATTTttatcaatag
3906748 3906769 [AIBSCS], [BPP], [GEA], [SM] [10], [33]
  CRP-cAMP activator bglGp2 nd -41.5 -191.5 bglG
acaaagttaaTAACTGCGAGCATGGTCATATTTttatcaatag
3906748 3906769 [AIBSCS], [BPP], [GEA], [SM], [AIBSCS], [BPP], [GEA], [SM] [10], [33], [34]
  CRP-cAMP repressor bhsAp Sigma24 -36.5 -76.5 bhsA
aaaatatcttGTATGTGATCCAGATCACATCTAtcatttagtt
1168986 1169008 [APIORCISFBSCS], [GEA], [APIORCISFBSCS], [BPP], [GEA] [11]
  CRP-cAMP activator caiFp Sigma70 -41.5 -123.5 caiF
ttgatgacatAAGCAGGATTTAGCTCACACTTAtcgacggtga
34166 34187 [BCE], [GEA] [35]
  CRP-cAMP activator caiTp Sigma70 -41.5 -147.5 caiT, caiA, caiB, caiC, caiD, caiE
acccgaaacaAAAATGTGATACCAATCACAGAAtacagcttat
42068 42090 [AIBSCS], [APIORCISFBSCS], [BCE], [GEA] [2], [12], [36], [37]
  CRP-cAMP activator cas3p Sigma70 nd -60.0 cas3
tgtaattcgaTATTTATGAGCAGCATCGAAAAAtagcccgctg
2887268 2887289 [APIORCISFBSCS], [BPP], [GEA], [SM] [38]
  CRP-cAMP repressor casAp Sigma70 -89.5 -270.5 casA, casB, casC, casD, casE, cas1, cas2
gtatgaatatTTTATGTAATAAAATTCATGGtaattattat
2884399 2884419 [APIORCISFBSCS], [BPP], [GEA] [39]
  CRP-cAMP repressor cddp Sigma70 -94.5 -119.5 cdd
taatgggctaAAATTTGCGATGCGTCGCGCATTtttgatgtat
2231714 2231735 [BPP], [GEA], [SM] [40], [41]
  CRP-cAMP activator cddp Sigma70 -92.5 -117.5 cdd
atgggctaaaATTTGCGATGCGTCGCGCATTTTtgatgtatgt
2231716 2231737 [BPP], [GEA], [SM] [40], [41]
  CRP-cAMP activator cddp Sigma70 -42.5 -67.5 cdd
gttgcataatTAATGAGATTCAGATCACATATAaagccacaac
2231766 2231787 [BPP], [GEA], [SM] [40], [41]
  CRP-cAMP repressor cddp Sigma70 -42.5 -67.5 cdd
gttgcataatTAATGAGATTCAGATCACATATAaagccacaac
2231766 2231787 [BPP], [GEA], [SM] [40], [41]
  CRP-cAMP activator chbBp nd -83.5 -190.5 chbB, chbC, chbA, chbR, chbF, chbG
ttatttgcccGAAATGTGAAGAGGGTCATAACCacaggtcaag
1821799 1821820 [AIBSCS], [APIORCISFBSCS], [BPP], [GEA] [10], [42]
  CRP-cAMP activator chiPp nd -70.5 -168.5 chiP, chiQ
catcaaaataTGTGCGGTTGCTCATGTtcttacattc
708158 708174 [APIORCISFBSCS] [43]
  CRP-cAMP activator cirAp1 Sigma70 118.5 -42.5 cirA
ggacgtgaagAAGATGTGAGCGATAACCCATTTtattttcgta
2246801 2246823 [APIORCISFBSCS], [GEA] [44]
  CRP-cAMP activator cirAp2 Sigma70 131.5 -42.5 cirA
ggacgtgaagAAGATGTGAGCGATAACCCATTTtattttcgta
2246801 2246823 [APIORCISFBSCS], [GEA] [44]
  CRP-cAMP repressor citCp2 nd 11.5 -172.5 citC, citD, citE, citF, citX, citG
aaccactaacTCTATGTGAAATAAATCAAAATTtcacgccgaa
652018 652039 [AIBSCS], [AIBSCS] [45]
  CRP-cAMP repressor comRp nd -152.5 -164.5 comR
aactaaatgaTAGATGTGATCTGGATCACATACaagatatttt
1168986 1169008 [APIORCISFBSCS], [BPP], [GEA] [11]
  CRP-cAMP activator cpdBp Sigma70 -44.0 -108.0 cpdB
atgaatgcgcCAACTGTGATAGTGTCATCATTTtcaaagcgta
4436662 4436683 [BCE], [SM]
  CRP-cAMP activator crpp1 Sigma70 -59.5 -226.5 crp
cgcgcaacggAAGGCGACCTGGGTCATGCTGAAgcgagacacc
3485883 3485904 [APIORCISFBSCS], [BPP], [SM] [46]
  CRP-cAMP repressor crpp1 Sigma70 41.5 -126.5 crp
atgtactgcaTGTATGCAAAGGACGTCACATTAccgtgcagta
3485983 3486004 [AIBSCS], [APIORCISFBSCS], [BPP], [GEA], [SM] [46]
  CRP-cAMP activator csgDp1 Sigma70 -170.5 -318.5 csgD, csgE, csgF, csgG
ttttatatgcATTATTAGTAAGTTATCACCATTtgtatgattt
1103504 1103525 [AIBSCS], [GEA] [10]
  CRP-cAMP activator csgDp1 Sigma70 -42.5 -190.5 csgD, csgE, csgF, csgG
aacgagttacATTTAGTTACATGTTTAACACTTgatttaagat
1103376 1103397 [AIBSCS], [GEA] [10]
  CRP-cAMP activator csgDp3 Sigma38 -170.5 -318.5 csgD, csgE, csgF, csgG
ttttatatgcATTATTAGTAAGTTATCACCATTtgtatgattt
1103504 1103525 [AIBSCS], [GEA] [10]
  CRP-cAMP activator csgDp3 Sigma38 -42.5 -190.5 csgD, csgE, csgF, csgG
aacgagttacATTTAGTTACATGTTTAACACTTgatttaagat
1103376 1103397 [AIBSCS], [GEA] [10]
  CRP-cAMP activator csiDp Sigma38 -68.5 -126.5 glaH, lhgD, gabD, gabT, gabP
atgttactaaTTTGTTGCTTTTGATCACAATAAgaaaacaata
2788848 2788869 [AIBSCS], [BPP], [GEA] [47], [48]
  CRP-cAMP activator csiEp Sigma70 -42.5 -76.5 csiE
acgcttgccaACATTTCTGATGATTAGCATTCCcttcgccatt
2665348 2665369 [GEA] [49]
  CRP-cAMP activator csiEp2 Sigma38 -42.5 -76.5 csiE
acgcttgccaACATTTCTGATGATTAGCATTCCcttcgccatt
2665348 2665369 [GEA] [49]
  CRP-cAMP activator cspDp Sigma70 -112.5 -198.5 cspD
ctatcgttggCATCAGCGACATCTGTCACATTCctgtcaatag
922778 922799 [APIORCISFBSCS], [BPP], [GEA], [SM] [50]
  CRP-cAMP activator cspDp Sigma70 -83.5 -169.5 cspD
attcctgtcaATAGCGTTAACTGCTTCAAATTTttgattcata
922749 922770 [AIBSCS], [BPP], [GEA], [SM] [50]
  CRP-cAMP activator cspEp2 Sigma70 -61.5 -103.5 cspE
acatcaaaaaTAACGCGACTTTTATCACTTTTTagtaaagtta
657178 657200 [APIORCISFBSCS], [BPP], [GEA], [SM] [51]
  CRP-cAMP activator csqRp Sigma70 -36.0 -64.0 csqR
cgggatccctGACTGTGATCAAACCCGATCTTTTttgtcacttt
4074594 4074617 [BPP], [GEA], [MCIBSPD] [52]
  CRP-cAMP repressor csqRp Sigma70 -36.0 -64.0 csqR
cgggatccctGACTGTGATCAAACCCGATCTTTTttgtcacttt
4074594 4074617 [BPP], [GEA], [MCIBSPD] [52]
  CRP-cAMP repressor csrCp nd -191.5 -191.5 csrC
gatttttcggCGTGAGCGTTGTAAGTAaaagccatac
4050837 4050853 [APIORCISFBSCS], [BPP], [GEA] [53]
  CRP-cAMP repressor csrCp nd -160.5 -160.5 csrC
ccatacgcttTGTGAGACATTGCCGATagtctttatg
4050868 4050884 [APIORCISFBSCS], [BPP], [GEA] [53]
  CRP-cAMP repressor csrCp nd -113.5 -113.5 csrC
gagaaaattcTGCGATGCATGTCAAATaagctatata
4050915 4050931 [APIORCISFBSCS], [BPP], [GEA] [53]
  CRP-cAMP activator cstAp1 nd -89.5 -128.5 cstA
actcggttaaCGGAGTGATCGAGTTAACATTGTtaagttaaat
629755 629776 [GEA], [SM] [54], [55], [56]
  CRP-cAMP repressor cyaAp Sigma70 -2.0 -156.0 cyaA
cagcaaggtgTTAAATTGATCACGTTTTAGACCattttttcgt
3990986 3991007 [APIORCISFBSCS], [BPP], [GEA] [57], [58]
  CRP-cAMP activator cyaRp Sigma70 -42.5 -42.5 cyaR
ggatggaaaaTTCTTAGAAACCGATCACATACAgctgcattta
2167061 2167082 [AIBSCS], [BPP], [GEA], [SM] [59]
  CRP-cAMP activator cyaRp2 Sigma24 -42.5 -42.5 cyaR
ggatggaaaaTTCTTAGAAACCGATCACATACAgctgcattta
2167061 2167082 [AIBSCS], [BPP], [GEA], [SM] [59]
  CRP-cAMP activator cyaRp3 Sigma38 -42.5 -42.5 cyaR
ggatggaaaaTTCTTAGAAACCGATCACATACAgctgcattta
2167061 2167082 [AIBSCS], [BPP], [GEA], [SM] [59]
  CRP-cAMP activator cyoAp Sigma70 -191.5 -234.5 cyoA, cyoB, cyoC, cyoD, cyoE
ttatttgttaAATAATTGTTTTATTTCACATTGgttataccaa
451834 451855 [AIBSCS], [GEA] [10]
  CRP-cAMP activator cyoAp Sigma70 -37.5 -80.5 cyoA, cyoB, cyoC, cyoD, cyoE
ccaagtaacaGGAATTTAATCATGTTTACAGTAatgtaacctt
451680 451701 [AIBSCS], [GEA] [10]
  CRP-cAMP activator cytRp Sigma70 -64.5 -117.5 cytR
ggcggatcgaAAAATTCAATATTCATCACACTTttcatgaaaa
4124563 4124584 [APIORCISFBSCS], [BPP], [GEA] [60], [61]
  CRP-cAMP repressor cytRp Sigma70 -64.5 -117.5 cytR
ggcggatcgaAAAATTCAATATTCATCACACTTttcatgaaaa
4124563 4124584 [APIORCISFBSCS], [BPP], [GEA] [60], [61]
  CRP-cAMP activator dadAp1 Sigma70 -43.5 -105.5 dadA, dadX
agagtcagggAGATGTGAGCCAGCTCACCATAAaaaagccgca
1237455 1237477 [APIORCISFBSCS], [BPP], [GEA] [62], [63], [64]
  CRP-cAMP activator dadAp1 Sigma70 20.5 -42.5 dadA, dadX
tgagttatcaAGATGTGATTAGATTATTATTCTtttactgtat
1237518 1237539 [APIORCISFBSCS], [BPP], [GEA] [62], [63]
  CRP-cAMP repressor dadAp1 Sigma70 20.5 -42.5 dadA, dadX
tgagttatcaAGATGTGATTAGATTATTATTCTtttactgtat
1237518 1237539 [APIORCISFBSCS], [BPP], [GEA] [62], [63]
  CRP-cAMP activator dadAp2 Sigma70 -59.5 -105.5 dadA, dadX
agagtcagggAGATGTGAGCCAGCTCACCATAAaaaagccgca
1237455 1237477 [APIORCISFBSCS], [BPP], [GEA] [64]
  CRP-cAMP activator dadAp2 Sigma70 7.0 -40.0 dadA, dadX
agttatcaagATGTGATTAGATTATTATTCTTTtactgtatct
1237520 1237541 [APIORCISFBSCS], [BPP], [GEA]
  CRP-cAMP activator dadAp3 Sigma70 -72.5 -105.5 dadA, dadX
agagtcagggAGATGTGAGCCAGCTCACCATAAaaaagccgca
1237455 1237477 [APIORCISFBSCS], [BPP], [GEA] [64]
  CRP-cAMP activator dadAp3 Sigma70 -9.5 -42.5 dadA, dadX
tgagttatcaAGATGTGATTAGATTATTATTCTtttactgtat
1237518 1237539 [APIORCISFBSCS], [BPP], [GEA], [APIORCISFBSCS], [BPP], [GEA] [62], [63], [64]
  CRP-cAMP activator dctAp Sigma70 -81.5 -132.5 dctA
aaagtgctggTTTGTGCGAGCCAGCTCAAACTTtttaaccttt
3683569 3683590 [APIORCISFBSCS], [BPP], [GEA] [31], [65]
  CRP-cAMP activator dcuBp Sigma70 -106.5 -126.5 dcuB, fumB
cagccaatatTCACTGTGAGGTATTTGCTAAAGccggtaacga
4348860 4348881 [APIORCISFBSCS], [GEA] [30]
  CRP-cAMP activator dcuRp Sigma70 -57.5 -588.5 dcuR
atgctgacgcACTTCGTGAACGATCCCACGAATttatgaataa
4350612 4350633 [APIORCISFBSCS], [BPP] [66]
  CRP-cAMP activator deoCp2 Sigma70 -93.5 -138.5 deoC, deoA, deoB, deoD
tgaaagtgaaTTATTTGAACCAGATCGCATTACagtgatgcaa
4617174 4617195 [AIBSCS], [APIORCISFBSCS], [BPP], [GEA], [SM] [10], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
  CRP-cAMP repressor deoCp2 Sigma70 -93.5 -138.5 deoC, deoA, deoB, deoD
tgaaagtgaaTTATTTGAACCAGATCGCATTACagtgatgcaa
4617174 4617195 [AIBSCS], [APIORCISFBSCS], [BPP], [GEA], [SM] [10], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
  CRP-cAMP activator deoCp2 Sigma70 -40.5 -85.5 deoC, deoA, deoB, deoD
agatttccttAATTGTGATGTGTATCGAAGTGTgttgcggagt
4617227 4617248 [APIORCISFBSCS], [BPP], [GEA], [SM] [67], [68], [69], [70], [72], [73], [74], [75], [76], [77]
  CRP-cAMP activator dgoRp Sigma70 -117.0 -142.0 dgoR, dgoK, dgoA, dgoD, dgoT
attgttctttTTGTGATCTAAATTGTAGTAcaacaatata
3875293 3875312 [AIBSCS], [BPP], [GEA], [SM] [78]
  CRP-cAMP repressor dpiBp nd 45.5 -206.5 dpiB, dpiA
ttcggcgtgaAATTTTGATTTATTTCACATAGAgttagtggtt
652018 652039 [AIBSCS] [45]
  CRP-cAMP activator dsdAp Sigma70 nd nd dsdA nd nd [BPP], [GEA], [IGI] [79]
  CRP-cAMP activator dsdXp Sigma70 -117.5 -143.5 dsdX, dsdA
tgagatgagcTAAAGTGAACCATATCTCAATTCaccttcattt
2477693 2477714 [BCE]
  CRP-cAMP activator dsdXp Sigma70 -87.5 -113.5 dsdX, dsdA
ttcaccttcaTTTTTAGATGTAAATCACTCCATtgatgcaatt
2477723 2477744 [BCE]
  CRP-cAMP activator dusBp Sigma70 -252.5 -286.5 dusB, fis
acgcggggcgAAGTGCGAGCAAGCTCACAAAAGgcacgtaaat
3409983 3410004 [AIBSCS], [GEA] [10]
  CRP-cAMP activator dusBp Sigma70 -167.5 -201.5 dusB, fis
cataaagaaaAATTGAGAACTTACTCAAATTTCtttgagtgta
3410068 3410089 [AIBSCS], [GEA] [10]
  CRP-cAMP activator dusBp Sigma70 -63.0 -97.0 dusB, fis
tttaaatgcaATTCTTTGATCCATCTCAGAGGAttggtcaaag
3410172 3410193 [BPP], [GEA] [80]
  CRP-cAMP repressor dusBp Sigma70 -63.0 -97.0 dusB, fis
tttaaatgcaATTCTTTGATCCATCTCAGAGGAttggtcaaag
3410172 3410193 [BPP], [GEA] [80]
  CRP-cAMP activator ebgAp Sigma70 nd nd ebgA, ebgC nd nd [BPP], [GEA], [IGI] [81]
  CRP-cAMP activator entCp Sigma70 -267.5 -321.5 entC, entE, entB, entA, entH
gcgtaatgacAAATTCGACAAAGCGCACAATCCgtcccctcgc
624553 624574 [AIBSCS], [GEA] [9]
  CRP-cAMP activator entCp Sigma70 -29.5 -83.5 entC, entE, entB, entA, entH
cgttacctcaAGAGTTGACATAGTGCGCGTTTGcttttaggtt
624791 624812 [AIBSCS], [GEA] [9]
  CRP-cAMP activator epdp Sigma70 -70.5 -202.5 epd, pgk, fbaA
aaaggggataAAAGTGTGATGTGAGTCAGATAAatgtcttctt
3073883 3073904 [APIORCISFBSCS], [BCE], [GEA], [SM] [82]
  CRP-cAMP activator epdp2 Sigma38 -70.5 -202.5 epd, pgk, fbaA
aaaggggataAAAGTGTGATGTGAGTCAGATAAatgtcttctt
3073883 3073904 [APIORCISFBSCS], [BCE], [GEA], [SM] [82]
  CRP-cAMP repressor exuRp2 Sigma70 -127.0 -161.0 exuR
gcgattgaggTGGCGCAGGAAACACATAAcgatcccgca
3246482 3246500 [APIORCISFBSCS], [GEA] [83]
  CRP-cAMP activator exuTp2 nd -161.5 -383.5 exuT
ccgaagatatTTTCGTGAGTTAGATCAATAAACgtagttaaaa
3244830 3244851 [AIBSCS] [84]
  CRP-cAMP activator exuTp2 nd -39.5 -261.5 exuT
atattcccacATTTGTGATGGCTCTCACCTTTTaaagttgtat
3244952 3244974 [AIBSCS], [APIORCISFBSCS], [GEA] [12], [84]
  CRP-cAMP activator fadDp Sigma70 -59.5 -120.5 fadD, sroD
agataaaaatAAATAGTGACGCGCTTCGCAACCttttcgttgg
1889856 1889877 [AIBSCS], [BPP], [GEA] [10], [85]
  CRP-cAMP activator fadHp nd -61.5 -102.5 fadH
ccgggcgtatTCTTTTTGAATCCCATCACAAACcccgcactcc
3231552 3231573 [APIORCISFBSCS], [GEA] [86]
  CRP-cAMP activator fadLp Sigma38 -157.5 -258.5 fadL
gcaaaatcggATAAGTGACCGAAATCACACTTAaaaatgatct
2461037 2461059 [BPP], [GEA] [85]
  CRP-cAMP activator feaBp1 Sigma70 -71.5 -98.5 feaB
tattgtcacgATTTGCGGAGCTTGTCACAGCTGacaaagcgaa
1447410 1447431 [APIORCISFBSCS], [GEA], [APIORCISFBSCS] [87]
  CRP-cAMP activator feaRp2 Sigma70 -111.5 -137.5 feaR
ttcgctttgtCAGCTGTGACAAGCTCCGCAAATcgtgacaata
1447410 1447431 [APIORCISFBSCS] [87]
  CRP-cAMP activator fecAp nd nd nd fecA, fecB, fecC, fecD, fecE nd nd [BPP], [GEA], [IGI] [9]
  CRP-cAMP activator fepAp Sigma70 -42.5 -215.5 fepA, entD
aaccccatgtTTACTGTGCAATTTTTCATTGATtgcagaaata
612699 612720 [AIBSCS], [GEA] [9]
  CRP-cAMP activator fiup Sigma70 -158.5 -275.5 fiu
cagatgttcgGTACTGCAACCATCTACAAATAAccccaccaac
841796 841817 [AIBSCS], [GEA] [9]
  CRP-cAMP activator fixAp Sigma70 -126.5 -204.5 fixA, fixB, fixC, fixX
gactttcaatATTGGTGATCCATAAAACAATATtgaaaatttc
42188 42209 [APIORCISFBSCS], [GEA] [2], [35], [36]
  CRP-cAMP activator fixAp Sigma70 -69.5 -147.5 fixA, fixB, fixC, fixX
tgttttcaatATTGGTGAGGAACTTAACAATATtgaaagttgg
42245 42266 [APIORCISFBSCS], [GEA] [2], [35], [36]
  CRP-cAMP activator flhDp Sigma70 -71.5 -269.5 flhD, flhC
aattgagtgtTTTGTGTGATCTGCATCACGCATtattgaaaat
1978456 1978477 [APIORCISFBSCS], [BPP], [GEA] [88], [89]
  CRP-cAMP activator focAp1 Sigma70 -40.5 -67.5 focA, pflB
taagccaggcGAGATATGATCTATATCAATTTCtcatctataa
954523 954544 [AIBSCS], [APIORCISFBSCS], [BCE], [GEA], [SM] [10], [90]
  CRP-cAMP activator fucAp Sigma70 nd nd fucA, fucO nd nd [BPP], [GEA], [IGI] [10], [91]
  CRP-cAMP activator fucPp Sigma70 -80.5 -196.5 fucP, fucI, fucK, fucU, fucR
tttcgattatTAAAGTGATGGTAGTCACATAAAgtcaccttct
2934028 2934049 [AIBSCS], [BPP], [GEA] [10], [92]
  CRP-cAMP activator fucPp Sigma70 -40.5 -156.5 fucP, fucI, fucK, fucU, fucR
tctagctaatAAGTGTGACCGCCGTCATATTACagagcgtttt
2934068 2934089 [BPP], [GEA], [SM] [92]
  CRP-cAMP activator fumAp Sigma70 -402.5 -465.5 fumA, fumC
gaatggagagTGGCTGTGCTGCGCATAATACTTtgaacaggaa
1688832 1688853 [AIBSCS], [GEA] [9], [31]
  CRP-cAMP activator fumAp Sigma70 -117.5 -180.5 fumA, fumC
gcatgatcaaTCCCTGTTTTAATGTGGAAATTAatcccactat
1688547 1688568 [APIORCISFBSCS], [GEA] [31], [93]
  CRP-cAMP activator fumAp Sigma70 -109.5 -172.5 fumA, fumC
aatccctgttTTAATGTGGAAATTAATCCCACTattaaagcaa
1688539 1688560 [APIORCISFBSCS], [GEA] [31], [93]
  CRP-cAMP activator fumAp Sigma70 -47.0 -110.0 fumA, fumC
ctggagccgcAAAAAGTCGTACTAGTCTCAGTTTttgttaaaaa
1688476 1688499 [APIORCISFBSCS], [GEA] [31], [94]
  CRP-cAMP activator fumAp Sigma70 63.5 -0.5 fumA, fumC
ccaggcagtaAGTGAGAGAACAATGTCAAACAAaccctttcat
1688367 1688389 [APIORCISFBSCS], [BPP], [GEA], [SM] [31], [95]
  CRP-cAMP unknown fumCp Sigma38 -484.5 -605.5 fumC
cgattatcgtCGGTCGTGATATTGCTCACGCCAaactgaaaga
1687183 1687205 [APIORCISFBSCS], [BPP], [GEA], [SM] [95]
  CRP-cAMP activator fumCp Sigma38 -53.5 -174.5 fumC
aatgacttctTCCAGCAGATACAACTCACACAAtgcacccgct
1686752 1686774 [APIORCISFBSCS], [BPP], [GEA], [SM] [95]