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Synonyms: Mlc, Mlc-EIIGlC |
Summary:
DgsA, better known as Mlc, "makes large colonies," [10]is a transcriptional dual regulator that controls the expression of a number of genes encoding enzymes of the Escherichia coli phosphotransferase (PTS) and phosphoenolpyruvate (PEP) systems [11, 12] It also regulates genes involved in the uptake of glucose [13] It is considered a global regulator of carbohydrate metabolism [3, 14]. In addition, Mlc regulates expression of the MalT transcriptional regulator, the activator of the maltose regulon [3]. Mlc repressor function is disabled by binding of Mlc to an actively-transported and dephosphorylated form of PtsG (EIICBGlc) [1, 2] The membrane-bound part of EIICBGlc is essential for Mlc inactivation [2, 15]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | ROK | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | mlc | ||||||||||||||||||
Genome position: | 1667344-1668564 | ||||||||||||||||||
Length: | 1221 bp / 406 aa | ||||||||||||||||||
Operon name: | mlc-ynfK | ||||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | crr, malT, manX, manY, manZ, mlc, ptsG, ptsH, ptsI, ynfK | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (8)
Phosphotransferase Systems (PEP-dependent PTS) (5)
membrane (4)
Transcription related (2)
operon (2)
Read more >
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Regulated operon(s) | malT, manXYZ, mlc-ynfK, ptsG, ptsHI-crr | ||||||
First gene in the operon(s) | malT, manX, mlc, ptsG, ptsH | ||||||
Simple and complex regulons | ArcA,CRP,Fis,Mlc,SoxS CRP,Cra,Mlc,NagC CRP,Lrp,Mlc CRP,Mlc CRP,Mlc,NagC Read more > | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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Mlc | repressor | malTp | Sigma70 | 12.0 | -50.0 | malT |
ccttataaccATTAATTACGAAGCGCAAAAAAAataatatttc
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3553024 | 3553046 | [GEA], [APIORCISFBSCS], [BCE] | [3] | |
Mlc | repressor | manXp | Sigma70 | -79.0 | -194.0 | manX, manY, manZ |
tgtgacaaggATATTTTACCTTTCGAAATTTCTgctaatcgaa
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1901843 | 1901865 | [GEA], [BCE] | [4] | |
Mlc | repressor | manXp | Sigma70 | -13.0 | -128.0 | manX, manY, manZ |
cataaaataaTTTTTTCGATATCTAAAATAAATcgcgaaacgc
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1901909 | 1901931 | [GEA], [BCE] | [4] | |
Mlc | repressor | mlcp | Sigma32 | 4.0 | -24.0 | mlc, ynfK |
tagcctacagATTATTTCGGAGCGCGAAAATATagggagtatg
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1668577 | 1668599 | [GEA], [APIORCISFBSCS], [BCE] | [3], [5] | |
Mlc | repressor | mlcp1 | Sigma70 | 16.0 | -24.0 | mlc |
tagcctacagATTATTTCGGAGCGCGAAAATATagggagtatg
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1668577 | 1668599 | [GEA], [APIORCISFBSCS], [BCE] | [3], [5] | |
Mlc | repressor | mlcp2 | Sigma70 | 4.0 | -24.0 | mlc, ynfK |
tagcctacagATTATTTCGGAGCGCGAAAATATagggagtatg
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1668577 | 1668599 | [GEA], [APIORCISFBSCS], [BCE] | [3], [5] | |
Mlc | repressor | ptsGp1 | nd | -6.0 | -109.0 | ptsG |
tggcactgaaTTATTTTACTCTGTGTAATAAATaaagggcgct
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1157749 | 1157771 | [GEA], [APIORCISFBSCS], [BPP] | [6], [7] | |
Mlc | repressor | ptsGp2 | Sigma70 | -35.0 | -278.0 | ptsG |
gttgaatgagTTTTTTTAAAGCTCGTAATTAATggctaaaacg
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1157580 | 1157602 | [GEA], [APIORCISFBSCS], [BPP] | [6] | |
Mlc | repressor | ptsHp | Sigma32 | 13.0 | -251.0 | ptsH, ptsI, crr |
aaccagactaATTATTTTGATGCGCGAAATTAAtcgttacagg
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2533502 | 2533524 | [GEA], [APIORCISFBSCS], [BPP] | [8], [9] | |
Mlc | repressor | ptsHp4 | Sigma70 | 13.0 | -251.0 | ptsH, ptsI, crr |
aaccagactaATTATTTTGATGCGCGAAATTAAtcgttacagg
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2533502 | 2533524 | [GEA], [APIORCISFBSCS], [BPP] | [8], [9] |
Alignment and PSSM for Mlc TFBSs | ![]() |
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Aligned TFBS of Mlc |
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Sequence | |
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AGTTTTTTTAAAGCTCGTAATTAATG | |
AATTATTTTGATGCGCGAAATTAATC | |
ATTTTTTTTGCGCTTCGTAATTAATG | |
AATTATTTTACTCTGTGTAATAAATA | |
GATTATTTCGGAGCGCGAAAATATAG | |
ATTTATTTTAGATATCGAAAAAATTA | |
GGATATTTTACCTTTCGAAATTTCTG |
Position weight matrix (PWM). Mlc matrix-quality result |
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A 5 3 1 0 5 0 0 0 0 4 2 3 0 1 0 0 0 4 7 7 2 2 6 4 1 2 C 0 0 0 0 0 0 0 0 1 0 3 1 2 3 0 6 0 0 0 0 0 0 0 1 0 1 G 2 2 0 0 0 0 0 0 0 3 2 1 3 0 3 0 7 0 0 0 0 0 0 0 0 4 T 0 2 6 7 2 7 7 7 6 0 0 2 2 3 4 1 0 3 0 0 5 5 1 2 6 0 |
Consensus |
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; consensus.strict aatTaTTTtgcagcgCGaAAttaatg ; consensus.strict.rc CATTAATTTCGCGCTGCAAAATAATT ; consensus.IUPAC rrtTaTTTtrsasykCGwAAttaatg ; consensus.IUPAC.rc CATTAATTWCGMRSTSYAAAATAAYY ; consensus.regexp [ag][ag]tTaTTTt[ag][cg]a[cg][ct][gt]CG[at]AAttaatg ; consensus.regexp.rc CATTAATT[AT]CG[AC][AG][CG]T[CG][CT]AAAATAA[CT][CT] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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