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FabR DNA-binding transcriptional repressor

Synonyms: FabR
FabR, "Fatty acid biosynthesis Regulator," represses expression of the fabA and fabB genes, which are essential for the synthesis of monounsaturated fatty acids [2] FabR directly influences membrane lipid homeostasis [2] It is a unique example of a transcription factor exclusively regulating expression of type II fatty acid synthase enzymes [2] The FabR consensus sequence has been identified as a palindromic sequence with a length of 18 bp [1, 2] DNA binding and repression require the binding of unsaturated acyl-ACP (acyl-acyl carrier protein) or acyl-CoA. Saturated acyl-ACP or acyl-CoA competes with the unsaturated fatty acids for binding to FabR but does not trigger DNA binding [] Thus, FabR senses the ratio, rather than the absolute amount, of unsaturated and saturated fatty acids and adjusts expression of fabA and fabB to balance the composition of saturated and unsaturated acyl-ACP [] L-threonine production increases when the fadR, fabR, and iclR regulators are deleted, suggesting that coupling fatty acid degradation and the L-threonine biosynthesis pathway via the glyoxylate shunt could efficiently increase L-threonine production [] The binding site for FabR overlaps with the binding site for FadR, the transcriptional activator for fabA and fabB in the promoter regions of both fabA and fabB.
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
FabR Functional   [IDA], [IEP], [IPI] [1], [2]
Evolutionary Family: TetR/AcrR
Connectivity class: Local Regulator
Gene name: fabR
  Genome position: 4161067-4161771
  Length: 705 bp / 234 aa
Operon name: fabR-yijD
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) fabA, fabB
Multifun term(s) of regulated gene(s)
fatty acids and phosphatidic acid (2)
Regulated operon(s) fabA, fabB
First gene in the operon(s) fabA, fabB
Simple and complex regulons FabR,FadR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  FabR repressor fabAp Sigma70 -19.5 -47.5 fabA
1016509 1016526 [AIBSCS], [APIORCISFBSCS], [BCE], [BPP], [GEA] [1], [2], [3]
  FabR repressor fabBp Sigma70 -20.5 -56.5 fabB
2441653 2441670 [APIORCISFBSCS], [BCE], [BPP], [GEA] [1], [2], [3]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation