RegulonDB

Regulon
Regulated gene(s)	argA, argB, argC, argD, argE, argF, argG, argH, argI, argR, artI, artJ, artM, artP, artQ, astA, astB, astC, astD, astE, carA, carB, gltB, gltD, gltF, hisJ, hisM, hisP, hisQ, infB, lysO, metY, nusA, pnp, rbfA, rimP, rpsO, truB
Multifun term(s) of regulated gene(s)	MultiFun Term (List of genes associated to the multifun term) arginine (16) argA, argB, argC, argD, argE, argF, argG, argH, argI, argR, artJ, artM, artP, artQ, carA, carB amino acids (5) artM, astA, astB, astD, astE ABC superfamily, membrane component (4) artM, artQ, hisM, hisQ membrane (4) artM, artQ, hisM, hisQ other (mechanical, nutritional, oxidative stress) (4) hisJ, hisM, hisP, hisQ ABC superfamily, periplasmic binding component (3) artI, artJ, hisJ nitrogen metabolism (3) astC, gltB, gltD ribosomes (3) rbfA, rimP, rpsO Transcription related (2) argR, nusA ABC superfamily ATP binding cytoplasmic component (2) artP, hisP pyrimidine biosynthesis (2) carA, carB glutamate (2) gltB, gltD translation (2) infB, rpsO lysine (1) argD prophage genes and phage related functions (1) argF activator (1) argR repressor (1) argR glutamine (1) artI operon (1) gltF Putative uncharacterized transport protein (1) lysO tRNA (1) metY transcriptional level (1) nusA RNA (1) pnp RNA degradation (1) pnp rRNA, stable RNA (1) rbfA temperature extremes (1) rbfA ribosomal proteins (1) rpsO RNA modification (1) truB Read more >
Regulated operon(s)	argA, argCBH, argD, argE, argF, argG, argI, argR, argT-hisJQMP, artJ, artPIQM, astCADBE, carAB, gltBDF, lysO, metY-rimP-nusA-infB-rbfA-truB-rpsO-pnp
First gene in the operon(s)	argA, argC, argD, argE, argF, argG, argI, argR, artJ, artP, astC, carA, gltB, hisJ, lysO, metY
Simple and complex regulons	AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac ArgR ArgR,CRP ArgR,DksA-ppGpp,ppGpp ArgR,H-NS ArgR,NtrC ArgR,PhoP Read more >
Simple and complex regulatory phrases	Regulatory phrase (List of promoters regulated by the phrase) [ArgR,-](16) argAp, argCp, argDp, argEp1, argFp, argGp, argIp, argRp1, artJp, artPp, carAp2, gltBp, gltBp2, hisJp, lysOp, metYp2 [ArgR,+](1) astCp2

Transcription factor binding sites (TFBSs) arrangements

Functional conformation	Function	Promoter	Sigma factor	Central Rel-Pos	Distance to first Gene	Genes	Sequence	LeftPos	RightPos	Evidence (Confirmed, Strong, Weak)	References
ArgR-L-arginine	repressor	argAp	Sigma70	46.5	-40.5	argA	ctgcgaaaaaACAGAATAAAAATACACTAatttcgaata nd	2949193	2949211	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP]	[1], [4]
ArgR-L-arginine	repressor	argAp	Sigma70	67.5	-19.5	argA	atacactaatTTCGAATAATCATGCAAAgaggtgtgcc nd	2949214	2949231	[EME], [GEA], [AIBSCS], [AIBSPD], [APIORCISFBSCS], [BPP], [CEE]	[1], [4]
ArgR-L-arginine	repressor	argCp	Sigma70	-3.5	-119.5	argC, argB, argH	ggtcatgataGTATCAATATTCATGCAGtatttatgaa nd	4154873	4154890	[GEA], [AIBSCS], [BCE], [BPP], [SM]	[1], [4]
ArgR-L-arginine	repressor	argCp	Sigma70	19.5	-97.5	argC, argB, argH	atgcagtattTATGAATAAAAATACACTaacgttgagc nd	4154895	4154912	[EME], [GEA], [AIBSCS], [AIBSPD], [BCE], [BPP], [CEE], [SM]	[1], [4]
ArgR-L-arginine	repressor	argDp	Sigma70	-19.5	-60.5	argD	attgccatttAGTGATTTTTTATGCATAttttgtggtt nd	3490232	3490249	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP]	[1], [4]
ArgR-L-arginine	repressor	argDp	Sigma70	2.5	-39.5	argD	atgcatatttTGTGGTTATAATTTCACAtttgtttatg nd	3490211	3490228	[EME], [AIBSCS], [AIBSPD], [BPP], [CEE]	[1], [4]
ArgR-L-arginine	repressor	argEp1	Sigma70	-6.5	-56.5	argE	gctcaacgttAGTGTATTTTTATTCATAaatactgcat nd	4154895	4154912	[EME], [GEA], [AIBSCS], [AIBSPD], [BCE], [BPP], [CEE], [SM]	[1], [4]
ArgR-L-arginine	repressor	argEp1	Sigma70	16.5	-34.5	argE	ttcataaataCTGCATGAATATTGATACtatcatgacc nd	4154873	4154890	[GEA], [AIBSCS], [BCE], [BPP], [SM]	[1], [4]
ArgR-L-arginine	repressor	argFp	Sigma70	-22.5	-57.5	argF	tggggttgcaAATGAATAATTACACATAtaaagtgaat nd	290354	290371	[GEA], [AIBSCS], [BCE], [BPP]	[1], [4], [5]
ArgR-L-arginine	repressor	argFp	Sigma70	-1.5	-36.5	argF	acacatataaAGTGAATTTTAATTCAATaagtggcgtt nd	290333	290350	[EME], [GEA], [AIBSCS], [AIBSPD], [BPP], [CEE], [SM]	[1], [4], [6]
ArgR-L-arginine	repressor	argGp	Sigma70	-125.5	-200.5	argG	ttgctaatcaTGTGAATGAATATCCAGTtcactttcat nd	3318428	3318445	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP]	[1], [4], [7]
ArgR-L-arginine	repressor	argGp	Sigma70	-6.5	-81.5	argG	ataaaagatgATTAAATGAAAACTCATTtattttgcat nd	3318547	3318564	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP]	[1], [4], [7]
ArgR-L-arginine	repressor	argGp	Sigma70	15.5	-60.5	argG	actcatttatTTTGCATAAAAATTCAGTgagagcggaa nd	3318568	3318585	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP]	[1], [4], [7]
ArgR-L-arginine	repressor	argIp	Sigma70	-22.5	-55.5	argI	tagacttgcaAATGAATAATCATCCATAtaaattgaat nd	4478358	4478375	[GEA], [AIBSCS], [BCE], [BPP]	[1], [4]
ArgR-L-arginine	repressor	argIp	Sigma70	-1.5	-34.5	argI	atccatataaATTGAATTTTAATTCATTgaggcgttag nd	4478337	4478354	[EME], [GEA], [AIBSCS], [AIBSPD], [BCE], [BPP], [CEE]	[1], [4]
ArgR-L-arginine	repressor	argRp1	Sigma70	-27.5	-53.5	argR	gggctgactgTTTGCATAAAAATTCATCtgtatgcaca nd	3384641	3384658	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP]	[1], [4], [5]
ArgR-L-arginine	repressor	argRp1	Sigma70	-7.5	-33.5	argR	aattcatctgTATGCACAATAATGTTGTatcaaccacc nd	3384661	3384678	[EME], [GEA], [AIBSCS], [AIBSPD], [APIORCISFBSCS], [BPP], [CEE]	[1], [4], [5]
ArgR-L-arginine	repressor	artJp	Sigma70	-48.5	-99.5	artJ	ttttatttcaTTTAAATTATTTAATCATGtttattgcat nd	900666	900684	[EME], [GEA], [AIBSPD], [BPP], [CEE], [SM]	[1], [8]
ArgR-L-arginine	repressor	artJp	Sigma70	-27.5	-78.5	artJ	taatcatgttTATTGCATATAAATTCACTtgatggcatt nd	900645	900663	[GEA], [AIBSCS], [BPP], [SM]	[1], [8]
ArgR	repressor	artPp	Sigma70	-50.5	-85.5	artP, artI, artQ, artM	tgcgctttgcTTTTAACTTTTAAAGCAGAaatattgcat nd	903811	903829	[EME], [GEA], [AIBSPD], [BPP], [CEE], [SM]	[1], [8]
ArgR	repressor	artPp	Sigma70	-29.5	-64.5	artP, artI, artQ, artM	aaagcagaaaTATTGCATAATTATTCTGTcaaaggtact nd	903790	903808	[GEA], [AIBSCS], [BPP], [SM]	[1], [8]
ArgR-L-arginine	activator	astCp2	Sigma54	-121.5	-183.5	astC, astA, astD, astB, astE	attcacccacATCGCAAACGTATTCACTttatatgcac nd	1832157	1832174	[EME], [GEA], [AIBSCS], [AIBSPD], [BPP], [CEE]	[1], [9]
ArgR-L-arginine	activator	astCp2	Sigma54	-99.5	-161.5	astC, astA, astD, astB, astE	ttcactttatATGCACTTTAAATGCATAtggtttggtt nd	1832135	1832152	[GEA], [AIBSCS], [BPP]	[9]
ArgR-L-arginine	activator	astCp2	Sigma54	-78.5	-140.5	astC, astA, astD, astB, astE	atgcatatggTTTGGTTATAACTCCTTGatttccagtt nd	1832114	1832131	[GEA], [AIBSCS], [BPP]	[9]
ArgR-L-arginine	activator	astCp2	Sigma54	-47.5	-109.5	astC, astA, astD, astB, astE	tccagttagcCTCCGCCGTTTATGCACTtttatcactg nd	1832083	1832100	[GEA], [AIBSCS], [BPP]	[9]
ArgR-L-arginine	repressor	carAp2	Sigma70	-8.5	-40.5	carA, carB	acgtcatcatTGTGAATTAATATGCAAAtaaagtgagt nd	29602	29619	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP], [SM]	[1], [4], [10]
ArgR-L-arginine	repressor	carAp2	Sigma70	13.5	-19.5	carA, carB	atgcaaataaAGTGAGTGAATATTCTCTggagggtgtt nd	29623	29640	[EME], [GEA], [AIBSCS], [AIBSPD], [APIORCISFBSCS], [BPP], [CEE], [SM]	[1], [4], [10]
ArgR-L-arginine	repressor	gltBp	Sigma70	-352.0	-568.0	gltB, gltD, gltF	gcttttatcaACTGCATAATCAATCAAAattaccgaaa nd	3354148	3354165	[GEA], [APIORCISFBSCS], [BPP]	[11], [12]
ArgR-L-arginine	repressor	gltBp	Sigma70	-331.5	-547.5	gltB, gltD, gltF	aatcaaaattACCGAAATTTCATGCATAatcacataaa nd	3354169	3354186	[GEA], [APIORCISFBSCS], [BPP]	[11], [12]
ArgR-L-arginine	repressor	gltBp2	Sigma38	-352.0	-568.0	gltB, gltD, gltF	gcttttatcaACTGCATAATCAATCAAAattaccgaaa nd	3354148	3354165	[GEA], [APIORCISFBSCS], [BPP]	[11], [12]
ArgR-L-arginine	repressor	gltBp2	Sigma38	-331.5	-547.5	gltB, gltD, gltF	aatcaaaattACCGAAATTTCATGCATAatcacataaa nd	3354169	3354186	[GEA], [APIORCISFBSCS], [BPP]	[11], [12]
ArgR-L-arginine	repressor	hisJp	Sigma70	-83.5	-132.5	hisJ, hisQ, hisM, hisP	tggtgcattgAAATGCATACTTAAGCATTtttaatgaaa nd	2426912	2426930	[EME], [GEA], [AIBSPD], [BPP], [CEE], [SM]	[1], [8]
ArgR-L-arginine	repressor	hisJp	Sigma70	-62.5	-111.5	hisJ, hisQ, hisM, hisP	taagcattttTAATGAAAAATAATACGTCtaacggggcg nd	2426891	2426909	[GEA], [AIBSCS], [BPP], [SM]	[1], [8]
ArgR-L-arginine	repressor	lysOp	Sigma70	-55.5	-93.5	lysO	tactgctcctTATGCATAACATTTCCTTttaattgcaa nd	914942	914959	[EME], [GEA], [AIBSPD], [BPP], [CEE], [SM]	[1], [13]
ArgR-L-arginine	repressor	lysOp	Sigma70	-34.5	-72.5	lysO	tttccttttaATTGCAACTTTACTCGTCcttccgcttt nd	914921	914938	[GEA], [BPP], [SM]	[13]
ArgR-L-arginine	repressor	metYp2	Sigma70	-201.5	-287.5	metY, rimP, nusA, infB, rbfA, truB, rpsO, pnp	ttccgctctcACTGAATTTTTATGCAAAataaatgagt nd	3318568	3318585	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP]	[1], [7]
ArgR-L-arginine	repressor	metYp2	Sigma70	-180.5	-266.5	metY, rimP, nusA, infB, rbfA, truB, rpsO, pnp	atgcaaaataAATGAGTTTTCATTTAATcatcttttat nd	3318547	3318564	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP]	[1], [7]
ArgR-L-arginine	repressor	metYp2	Sigma70	-61.5	-147.5	metY, rimP, nusA, infB, rbfA, truB, rpsO, pnp	atgaaagtgaACTGGATATTCATTCACAtgattagcaa nd	3318428	3318445	[GEA], [AIBSCS], [APIORCISFBSCS], [BPP]	[1], [7]

	Sequence
	gcttttatcaACTGCATAATCAATCAAAattaccgaaa	[-352.0, gltBp, forward] [-352.0, gltBp2, forward]
	aatcaaaattACCGAAATTTCATGCATAatcacataaa	[-331.5, gltBp, forward] [-331.5, gltBp2, forward]
	actcatttatTTTGCATAAAAATTCAGTgagagcggaa	[15.5, argGp, forward] [-201.5, metYp2, reverse]
	ataaaagatgATTAAATGAAAACTCATTtattttgcat	[-6.5, argGp, forward] [-180.5, metYp2, reverse]
	ttgctaatcaTGTGAATGAATATCCAGTtcactttcat	[-125.5, argGp, forward] [-61.5, metYp2, reverse]
	attcacccacATCGCAAACGTATTCACTttatatgcac	[-121.5, astCp2, reverse]
	ttcactttatATGCACTTTAAATGCATAtggtttggtt	[-99.5, astCp2, reverse]
	tggtgcattgAAATGCATACTTAAGCATTtttaatgaaa	[-83.5, hisJp, reverse]
	atgcatatggTTTGGTTATAACTCCTTGatttccagtt	[-78.5, astCp2, reverse]
	taagcattttTAATGAAAAATAATACGTCtaacggggcg	[-62.5, hisJp, reverse]
	tactgctcctTATGCATAACATTTCCTTttaattgcaa	[-55.5, lysOp, reverse]
	tgcgctttgcTTTTAACTTTTAAAGCAGAaatattgcat	[-50.5, artPp, reverse]
	ttttatttcaTTTAAATTATTTAATCATGtttattgcat	[-48.5, artJp, reverse]
	tccagttagcCTCCGCCGTTTATGCACTtttatcactg	[-47.5, astCp2, reverse]
	tttccttttaATTGCAACTTTACTCGTCcttccgcttt	[-34.5, lysOp, reverse]
	aaagcagaaaTATTGCATAATTATTCTGTcaaaggtact	[-29.5, artPp, reverse]
	taatcatgttTATTGCATATAAATTCACTtgatggcatt	[-27.5, artJp, reverse]
	gggctgactgTTTGCATAAAAATTCATCtgtatgcaca	[-27.5, argRp1, forward]
	tggggttgcaAATGAATAATTACACATAtaaagtgaat	[-22.5, argFp, reverse]
	tagacttgcaAATGAATAATCATCCATAtaaattgaat	[-22.5, argIp, reverse]
	attgccatttAGTGATTTTTTATGCATAttttgtggtt	[-19.5, argDp, reverse]
	acgtcatcatTGTGAATTAATATGCAAAtaaagtgagt	[-8.5, carAp2, forward]
	aattcatctgTATGCACAATAATGTTGTatcaaccacc	[-7.5, argRp1, forward]
	atgcagtattTATGAATAAAAATACACTaacgttgagc	[19.5, argCp, forward] [-6.5, argEp1, reverse]
	ggtcatgataGTATCAATATTCATGCAGtatttatgaa	[-3.5, argCp, forward] [16.5, argEp1, reverse]
	atccatataaATTGAATTTTAATTCATTgaggcgttag	[-1.5, argIp, reverse]
	acacatataaAGTGAATTTTAATTCAATaagtggcgtt	[-1.5, argFp, reverse]
	atgcatatttTGTGGTTATAATTTCACAtttgtttatg	[2.5, argDp, reverse]
	atgcaaataaAGTGAGTGAATATTCTCTggagggtgtt	[13.5, carAp2, forward]
	ctgcgaaaaaACAGAATAAAAATACACTAatttcgaata	[46.5, argAp, forward]
	atacactaatTTCGAATAATCATGCAAAgaggtgtgcc	[67.5, argAp, forward]

High-throughput Transcription factor binding sites (TFBSs)

Functional conformation	Function	Object name	Object type	Distance to first Gene	Sequence	LeftPos	RightPos	Center Position	Growth Condition	Evidence (Confirmed, Strong, Weak)	References
ArgR-L-arginine	activator	gltP	Gene	nd	nd nd	4294256	4294295	4294275.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	activator	ykgA	Gene	nd	nd nd	316883	316922	316902.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	activator	gltP	Gene	nd	nd nd	4294288	4294327	4294307.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	activator	yaaU	Gene	nd	nd nd	45774	45813	45793.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	activator	puuB	Gene	nd	nd nd	1364244	1364283	1364263.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	activator	eutS	Gene	nd	nd nd	2575928	2575967	2575947.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	activator	yraQ	Gene	nd	nd nd	3298201	3298240	3298220.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	activator	gltP	Gene	nd	nd nd	4294147	4294186	4294166.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	activator	aroP	Gene	nd	nd nd	121792	121831	121811.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	activator	yffB	Gene	nd	nd nd	2591207	2591246	2591226.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	yhcC	Transcription-Unit	-117.0	tttatgtgatTATGCATGAAATTTCGGTAATTTTGATTGATTATGCAGTtgataaaagc nd	3354148	3354187	3354167.0	nd	[EME], [GEA], [AIBSCS], [AIBSPD], [BPP], [CEE]	[1], [11], [14]
ArgR-L-arginine	repressor	waaA	Gene	nd	nd nd	3808394	3808433	3808413.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	hchA	Gene	nd	nd nd	2035484	2035523	2035503.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	stpA	Gene	nd	nd nd	2798743	2798782	2798762.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	cvpA	Gene	nd	nd nd	2430869	2430908	2430888.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	dacC	Gene	nd	nd nd	880767	880806	880786.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	gltB	Gene	nd	nd nd	3354541	3354580	3354560.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	mcaS	Gene	nd	nd nd	1405819	1405858	1405838.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	pyrL	Gene	nd	nd nd	4472623	4472662	4472642.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	aroK	Gene	nd	nd nd	3519202	3519241	3519221.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	hisL	Gene	nd	nd nd	2089964	2090003	2089983.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	lrp	Gene	nd	nd nd	932353	932392	932372.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	ftsZ	Gene	nd	nd nd	105232	105271	105251.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	hchA	Gene	nd	nd nd	2035538	2035577	2035557.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	dps	Gene	nd	nd nd	849151	849190	849170.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	mukE	Gene	nd	nd nd	975739	975778	975758.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	potF	Gene	nd	nd nd	893697	893736	893716.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	pfkB	Gene	nd	nd nd	1806222	1806261	1806241.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	ydgI	Gene	nd	nd nd	1679490	1679529	1679509.0	nd	[EME], [AIBSPD], [CEE]	[1]
ArgR-L-arginine	repressor	yfcC	Gene	nd	nd nd	2416994	2417033	2417013.0	nd	[EME], [AIBSPD], [CEE]	[1]

Other High-throughput regulatory interactions with weak evidence

Alignment and PSSM for ArgR TFBSs

Aligned TFBS of ArgR

	Sequence
	TATTTTGCATAAAAATTCAGT
	TTTATTGCATATAAATTCACT
	AATATTGCATAATTATTCTGT
	CTGTTTGCATAAAAATTCATC
	CTTATTGAATTAAAATTCACT
	TTATATGGATGATTATTCATT
	TTATTTGCATATTAATTCACA
	AAATATGCATAAAAAATCACT
	ATTTATGAATAAAAATACACT
	TAAATTGAATTTTAATTCATT
	TCATGTGAATGAATATCCAGT
	AATTTTGATTGATTATGCAGT
	TTATATGTGTAATTATTCATT
	GATTATGCATGAAATTTCGGT
	AAAAATGCTTAAGTATGCATT
	TAAAGTGAGTGAATATTCTCT
	AATACTGCATGAATATTGATA
	CTCTTTGCATGATTATTCGAA
	ATTAGTGTATTTTTATTCTGT
	TTTTGTGGTTATAATTTCACA
	CCTTATGCATAACATTTCCTT
	ATGATTAAATGAAAACTCATT
	TTTAATGAAAAATAATACGTC
	CTGTATGCACAATAATGTTGT
	ATTTCTGCTTTAAAAGTTAAA
	CCATATGCATTTAAAGTGCAT
	TAAAGTGAATACGTTTGCGAT
	TTAATTGCAACTTTACTCGTC
	AAACATGATTAAATAATTTAA
	TGGTTTGGTTATAACTCCTTG
	AAAAGTGCATAAACGGCGGAG

Position weight matrix (PWM). ArgR matrix-quality result

A	11	12	13	13	11	0	1	10	23	2	17	22	17	17	25	2	2	0	17	6	6
C	6	3	1	1	2	0	0	16	0	1	1	1	1	1	1	2	3	25	2	7	3
G	1	1	4	0	6	0	30	3	2	0	8	0	2	0	1	3	4	3	6	7	2
T	13	15	13	17	12	31	0	2	6	28	5	8	11	13	4	24	22	3	6	11	20

Consensus

;	consensus.strict             	ttattTGcaTaaaaattCatt
;	consensus.strict.rc          	AATGAATTTTTATGCAAATAA
;	consensus.IUPAC              	wwwwwTGmaTrawwattCabt
;	consensus.IUPAC.rc           	AVTGAATWWTYATKCAWWWWW
;	consensus.regexp             	[at][at][at][at][at]TG[ac]aT[ag]a[at][at]attCa[cgt]t
;	consensus.regexp.rc          	A[ACG]TGAAT[AT][AT]T[CT]AT[GT]CA[AT][AT][AT][AT][AT]

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Evolutionary conservation of regulatory elements

Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.

TF-target gene evolutionary conservation
Promoter-target gene evolutionary conservation

Evidence
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[IDA] Inferred from direct assay
[IPI] Inferred from physical interaction
[AIBSCS] Automated inference based on similarity to consensus sequences
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[EME] Expression microarray evidence
[AIBSPD] Automated inference based on sequence pattern discovery
[CEE] ChIP-exo evidence
[BCE] Binding of cellular extracts
[SM] Site mutation

Reference(s)
[1] Caldara M., Charlier D., Cunin R., 2006, The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation., Microbiology 152(Pt 11):3343-54
[2] Lim DB., Oppenheim JD., Eckhardt T., Maas WK., 1987, Nucleotide sequence of the argR gene of Escherichia coli K-12 and isolation of its product, the arginine repressor., Proc Natl Acad Sci U S A 84(19):6697-701
[3] Szwajkajzer D., Dai L., Fukayama JW., Abramczyk B., Fairman R., Carey J., 2001, Quantitative analysis of DNA binding by the Escherichia coli arginine repressor., J Mol Biol 312(5):949-62
[4] Charlier D., Roovers M., Van Vliet F., Boyen A., Cunin R., Nakamura Y., Glansdorff N., Pierard A., 1992, Arginine regulon of Escherichia coli K-12. A study of repressor-operator interactions and of in vitro binding affinities versus in vivo repression., J Mol Biol 226(2):367-86
[5] Levitt M., 1992, Accurate modeling of protein conformation by automatic segment matching., J Mol Biol 226(2):507-33
[6] Tian G., Maas WK., 1994, Mutational analysis of the arginine repressor of Escherichia coli., Mol Microbiol 13(4):599-608
[7] Krin E., Laurent-Winter C., Bertin PN., Danchin A., Kolb A., 2003, Transcription regulation coupling of the divergent argG and metY promoters in Escherichia coli K-12., J Bacteriol 185(10):3139-46
[8] Caldara M., Minh PN., Bostoen S., Massant J., Charlier D., 2007, ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12., J Mol Biol 373(2):251-67
[9] Kiupakis AK., Reitzer L., 2002, ArgR-independent induction and ArgR-dependent superinduction of the astCADBE operon in Escherichia coli., J Bacteriol 184(11):2940-50
[10] Charlier D., Weyens G., Roovers M., Piette J., Bocquet C., Pierard A., Glansdorff N., 1988, Molecular interactions in the control region of the carAB operon encoding Escherichia coli carbamoylphosphate synthetase., J Mol Biol 204(4):867-77
[11] Cho S., Cho YB., Kang TJ., Kim SC., Palsson B., Cho BK., 2015, The architecture of ArgR-DNA complexes at the genome-scale in Escherichia coli., Nucleic Acids Res 43(6):3079-88
[12] Paul L., Mishra PK., Blumenthal RM., Matthews RG., 2007, Integration of regulatory signals through involvement of multiple global regulators: control of the Escherichia coli gltBDF operon by Lrp, IHF, Crp, and ArgR., BMC Microbiol 7:2
[13] Pathania A., Sardesai AA., 2015, Distinct Paths for Basic Amino Acid Export in Escherichia coli: YbjE (LysO) Mediates Export of L-Lysine., J Bacteriol 197(12):2036-47
[14] Cho BK., Federowicz S., Park YS., Zengler K., Palsson BO., 2011, Deciphering the transcriptional regulatory logic of amino acid metabolism., Nat Chem Biol 8(1):65-71

RegulonDB