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Synonyms: SdiA |
Summary:
The transcription factor SdiA, for "Suppressor of the cell division inhibitor," is possibly positively autoregulated and controls the transcription of the genes involved in cell division [1, 6, 7, 8, 9] and acid tolerance [3]. SdiA has been shown to increase transcription from the P2 promoter of the ftsQAZ operon [7] by facilitating RNA polymerase binding to the promoter region [1]. SdiA activates the expression of ydiV, which is involved in the interaction between two quorum-sensing systems. An sdiA ydiV double mutant reduces cAMP levels, which inhibits quorum-sensing system 2 [5]. Expression of sdiA itself is regulated by a mechanism similar to quorum sensing: exposure to conditioned medium results in a 50-80% decrease in sdiA expression [6]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | LuxR/UhpA | ||||||||||||||||
Sensing class: | External sensing using transported metabolites | ||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||
Gene name: | sdiA | ||||||||||||||||
Genome position: | 1996110-1996832 | ||||||||||||||||
Length: | 723 bp / 240 aa | ||||||||||||||||
Operon name: | sdiA | ||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | ftsA, ftsQ, ftsZ, gadW, gadY, rflP, rmf, rsd | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
cell division (3)
Transcription related (2)
membrane (1)
repressor (1)
antisense RNA (1)
Read more >
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Regulated operon(s) | gadAXW, gadY, mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC, rflP, rmf, rsd | ||||||
First gene in the operon(s) | ftsQ, gadW, gadY, rmf, rsd, rflP | ||||||
Simple and complex regulons | ArcA,CRP,McbR,RcdA,SdiA,SlyA,ppGpp ArcA,McbR,RcdA,SdiA,SlyA GadW,GadX,H-NS,PhoP,SdiA GadW,GadX,RcsB,SdiA SdiA Read more > | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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SdiA | repressor | ftsQp | Sigma38 | -163.5 | -451.5 | ftsQ, ftsA, ftsZ |
tgtgggaatgTCAAAAGTAGTAGCAGAAaatgctctac
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102695 | 102712 | [GEA], [BPP] | [1] | |
SdiA | repressor | ftsQp | Sigma38 | -161.5 | -449.5 | ftsQ, ftsA, ftsZ |
tgggaatgtcAAAAGTAGTAGCAGAAAAtgctctacaa
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102697 | 102714 | [GEA], [BPP] | [1] | |
SdiA | repressor | ftsQp | Sigma38 | -15.5 | -303.5 | ftsQ, ftsA, ftsZ |
atacgtattcAACCGTCCGGAACCTTCTatgattatga
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102843 | 102860 | [BPP] | [1] | |
SdiA | repressor | ftsQp1 | Sigma70 | -163.5 | -451.5 | ftsQ, ftsA, ftsZ |
tgtgggaatgTCAAAAGTAGTAGCAGAAaatgctctac
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102695 | 102712 | [GEA], [BPP] | [1] | |
SdiA | repressor | ftsQp1 | Sigma70 | -161.5 | -449.5 | ftsQ, ftsA, ftsZ |
tgggaatgtcAAAAGTAGTAGCAGAAAAtgctctacaa
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102697 | 102714 | [GEA], [BPP] | [1] | |
SdiA | repressor | ftsQp1 | Sigma70 | -15.5 | -303.5 | ftsQ, ftsA, ftsZ |
atacgtattcAACCGTCCGGAACCTTCTatgattatga
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102843 | 102860 | [BPP] | [1] | |
SdiA | activator | ftsQp2 | Sigma38 | -36.5 | -449.5 | ftsQ |
tgggaatgtcAAAAGTAGTAGCAGAAAAtgctctacaa
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102697 | 102714 | [GEA], [BPP] | [1] | |
SdiA | activator | gadWp2 | nd | nd | nd | gadW | nd | nd | [GEA], [BPP] | [2], [3] | ||
SdiA | activator | gadYp | Sigma38 | nd | nd | gadY | nd | nd | [GEA], [BPP] | [3] | ||
SdiA | activator | rmfp | nd | nd | nd | rmf | nd | nd | [GEA], [BPP] | [4] | ||
SdiA | activator | rsdp2 | Sigma70 | nd | nd | rsd | nd | nd | [GEA], [BPP] | [4] | ||
SdiA | activator | ydiVp | Sigma24 | -53.0 | -120.0 | rflP |
gataatctaaAAAAAGGACCCCTGAAAAagtggttaac
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1792132 | 1792149 | [GEA], [AIBSCS], [BPP] | [5] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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