![]() ![]() |
Synonyms: IdnR-5-dehydro-D-gluconate, IdnR-Idonate, IdnR |
Summary:
"L-idonate regulator," IdnR, is a transcription factor that regulates genes involved in L-idonate metabolism, which are organized in two coordinately regulated transcription units [1, 3]. This regulator is positively autoregulated and co-regulates with CRP, a global transcriptional regulator; these regulators bind cooperatively to activate transcription of an operon related to transport and catabolism of L-idonate [1]. Synthesis of this operon is induced when Escherichia coli is grown on L-idonate/5KG in the absence of glucose and gluconate. In addition, this regulator represses transcription of genes related to gluconate metabolism [3]. In the presence of L-idonate, IdnR binds to 16-nucleotide-long DNA-target sites in the idnK/idnDOTR intergenic region to coordinately activate transcription of idnKp and idnDp [1]. IdnR exhibits a high similarity to GntR (53%) and belongs to the LacI/GalR family of transcriptional regulators [5]. Read more > |
Transcription factor | ![]() ![]() |
||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TF conformation(s): |
|
||||||||||||||||||||||||
Evolutionary Family: | GalR/LacI | ||||||||||||||||||||||||
Sensing class: | Sensing external and internal signals | ||||||||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||||||||
Gene name: | idnR | ||||||||||||||||||||||||
Genome position: | 4490141-4491139 | ||||||||||||||||||||||||
Length: | 999 bp / 332 aa | ||||||||||||||||||||||||
Operon name: | idnDOTR | ||||||||||||||||||||||||
TU(s) encoding the TF: |
|
Regulon |
![]() ![]() |
||||||
---|---|---|---|---|---|---|---|
Regulated gene(s) | gntK, gntU, idnD, idnK, idnO, idnR, idnT | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (4)
Porters (Uni-, Sym- and Antiporters) (2)
membrane (2)
misc. glucose metabolism (1)
Transcription related (1)
Read more >
|
||||||
Regulated operon(s) | gntRKU, idnDOTR, idnK | ||||||
First gene in the operon(s) | gntK, idnD, idnK | ||||||
Simple and complex regulons | CRP,GntR,IdnR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
![]() |
---|
Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
IdnR-5-dehydro-D-gluconate | repressor | gntKp | Sigma70 | 2.5 | -51.5 | gntK, gntU |
cggctggacaATGTTACCGATAACAGttacccgtaa
|
3577636 | 3577651 | [GEA] | [2] | |
IdnR-5-dehydro-D-gluconate | repressor | gntKp | Sigma70 | 15.5 | -38.5 | gntK, gntU |
ttaccgataaCAGTTACCCGTAACATttttaattct
|
3577623 | 3577638 | [GEA] | [2] | |
IdnR-5-dehydro-D-gluconate | activator | idnDp | nd | -78.5 | -107.5 | idnD, idnO, idnT, idnR |
aaggcacatcACGTTATGCGTAACATagtaatgtaa
|
4494506 | 4494521 | [GEA], [AIBSCS] | [3], [4] | |
IdnR | activator | idnKp | Sigma70 | -83.5 | -109.5 | idnK |
ttacattactATGTTACGCATAACGTgatgtgcctt
|
4494506 | 4494521 | [GEA], [AIBSCS] | [3], [4] |
Evolutionary conservation of regulatory elements | ![]() |
---|
Reference(s) |
![]() |
---|---|