![]() ![]() |
Synonyms: AsnC-L-asparagine, AsnC |
Summary:
AsnC is a transcriptional regulator that activates the expression of asnA, a gene involved in the synthesis of asparagine [2, 4] However, when asparagine is present the activation of asnA is turned off. On the other hand, AsnC is negatively autoregulated, but the presence of asparagine does not affect this regulation [2] AsnC belongs to the AsnC family of regulatory proteins whose members are widely distributed in archaea and bacteria [5] It has been postulated that AsnC is very ascient; it appears that it was present before the divergence of archea and bacteria [5] This protein has a DNA-binding domain with a helix-turn-helix motif in the N terminus and an effector-binding C-terminal domain [1] A crystal structure of AsnC complexed with the ligand l-asparagine has been solved at 2.4-Å resolution. Read more > |
Transcription factor | ![]() ![]() |
||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TF conformation(s): |
|
||||||||||||||||||
Evolutionary Family: | AsnC | ||||||||||||||||||
Sensing class: | Sensing external and internal signals | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | asnC | ||||||||||||||||||
Genome position: | 3926545-3927003 | ||||||||||||||||||
Length: | 459 bp / 152 aa | ||||||||||||||||||
Operon name: | asnC-mioC-mnmG-rsmG | ||||||||||||||||||
TU(s) encoding the TF: |
|
Regulon |
![]() ![]() |
||||||
---|---|---|---|---|---|---|---|
Regulated gene(s) | asnA, asnC, mioC, mnmG | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
asparagine (2)
Transcription related (1)
activator (1)
repressor (1)
regulon (1)
Read more >
|
||||||
Regulated operon(s) | asnA, asnC-mioC-mnmG-rsmG | ||||||
First gene in the operon(s) | asnA, asnC | ||||||
Simple and complex regulons | AsnC AsnC,Nac | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
![]() |
---|
Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
AsnC | activator | asnAp | Sigma70 | -109.5 | -135.5 | asnA |
taggattttcTTATGCGGATTGATgattcattct
|
3927013 | 3927026 | [GEA], [AIBSCS] | [2] | |
AsnC | activator | asnAp | Sigma70 | -75.5 | -101.5 | asnA |
attttagcctTCTTTTTTAATGAAtcaaaagtga
|
3927047 | 3927060 | [GEA], [AIBSCS] | [2] | |
AsnC | activator | asnAp | Sigma70 | -43.5 | -69.5 | asnA |
gagttaggctTTTTATTGAATGATtattgcatgt
|
3927079 | 3927092 | [GEA], [AIBSCS] | [2], [3] | |
AsnC | activator | asnAp | Sigma70 | -12.5 | -38.5 | asnA |
tgtgtgtcggTTTTTGTTGCTTAAtcataagcaa
|
3927110 | 3927123 | [GEA], [AIBSCS] | [2] | |
AsnC | repressor | asnCp | Sigma70 | -85.5 | -113.5 | asnC, mioC, mnmG |
ttgcttatgaTTAAGCAACAAAAAccgacacaca
|
3927110 | 3927123 | [GEA], [AIBSCS] | [2] | |
AsnC | repressor | asnCp | Sigma70 | -54.5 | -82.5 | asnC, mioC, mnmG |
acatgcaataATCATTCAATAAAAagcctaactc
|
3927079 | 3927092 | [GEA], [AIBSCS] | [2] | |
AsnC | repressor | asnCp | Sigma70 | -22.5 | -50.5 | asnC, mioC, mnmG |
tcacttttgaTTCATTAAAAAAGAaggctaaaat
|
3927047 | 3927060 | [GEA], [AIBSCS] | [2] | |
AsnC | repressor | asnCp | Sigma70 | 12.5 | -16.5 | asnC, mioC, mnmG |
agaatgaatcATCAATCCGCATAAgaaaatccta
|
3927013 | 3927026 | [GEA], [AIBSCS] | [2] |
Alignment and PSSM for AsnC TFBSs | ![]() |
---|
Aligned TFBS of AsnC |
---|
Sequence | |
---|---|
TGATTCATTAAAAAAGA | |
TGATTAAGCAACAAAAA | |
TCATTCAATAAAAAGCC | |
TCAATCCGCATAAGAAA |
Position weight matrix (PWM). AsnC matrix-quality result |
---|
A 0 0 4 1 0 1 3 1 0 4 3 3 4 3 3 2 3 C 0 2 0 0 0 3 1 0 2 0 0 1 0 0 0 1 1 G 0 2 0 0 0 0 0 2 0 0 0 0 0 1 1 1 0 T 4 0 0 3 4 0 0 1 2 0 1 0 0 0 0 0 0 |
Consensus |
---|
; consensus.strict TgAtTCagcAaaAaaaa ; consensus.strict.rc TTTTTTTTGCTGAATCA ; consensus.IUPAC TsAtTCmgyAamArrvm ; consensus.IUPAC.rc KBYYTKTTRCKGAATSA ; consensus.regexp T[cg]AtTC[ac]g[ct]Aa[ac]A[ag][ag][acg][ac] ; consensus.regexp.rc [GT][CGT][CT][CT]T[GT]TT[AG]C[GT]GAAT[CG]A |
Evolutionary conservation of regulatory elements | ![]() |
---|
Reference(s) |
![]() |
---|---|