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| Synonyms: SrlR-D-sorbitol, SrlR |
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Summary:
The "glucitol repressor," GutR, is a DNA-binding transcription factor that represses an operon (gut) involved in transport and utilization of glucitol [1, 2] This regulator is located in the unusual gut operon, which contains two glucitol-specific transcription factors, GutR and GutM, that regulate this operon negatively and positively, respectively; both regulators control transcription of glucitol PTS permease [1] Expression of gutR is activated in the presence of glucitol and in the absence of glucose. Although DNA binding by GutM does not depend on the presence of glucitol, this compound appears to be necessary for derepressing gutM, perhaps by interacting with GutR [1] In addition, Yamada et al. suggested that these regulators have contrary effects, but in the presence of glucitol, GutR interacts with this carbohydrate to dissociate from DNA, causing increments of GutM in sufficient amounts to increase transcription of the gut operon [1] To repress transcription, GutR recognizes DNA-binding sites, but no consensus sequence has been identified. Read more > |
| Transcription factor |  |
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| TF conformation(s): |
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| Evolutionary Family: | DeoR | |||||||||||||||||||||
| TFBs symmetry: | inverted-repeat | |||||||||||||||||||||
| Sensing class: | External sensing using transported metabolites | |||||||||||||||||||||
| Connectivity class: | Local Regulator | |||||||||||||||||||||
| Gene name: | srlR | |||||||||||||||||||||
| Genome position: | 2829047-2829820 | |||||||||||||||||||||
| Length: | 774 bp / 257 aa | |||||||||||||||||||||
| Operon name: | srlAEBD-gutM-srlR-gutQ | |||||||||||||||||||||
| TU(s) encoding the TF: |
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| Regulon |
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| Regulated gene(s) | gutM, gutQ, srlA, srlB, srlD, srlE, srlR | ||||||
| Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (6)
Phosphotransferase Systems (PEP-dependent PTS) (3)
Transcription related (2)
activator (1)
core region (1)
Read more >
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| Regulated operon(s) | srlAEBD-gutM-srlR-gutQ | ||||||
| First gene in the operon(s) | srlA | ||||||
| Simple and complex regulons | CRP,GutM,H-NS,SrlR | ||||||
| Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) | ||||||
| Transcription factor regulation |
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Transcription factor binding sites (TFBSs) arrangements
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| Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | References | |
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| SrlR | repressor | srlAp | Sigma70 | nd | nd | srlA, srlE, srlB, srlD, gutM, srlR, gutQ | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS] | W | [1], [1] |
| Evolutionary conservation of regulatory elements | |
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| Promoter-target gene evolutionary conservation |
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| Reference(s) |
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[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis